Olfactory axon pathfinding: who is the pied piper?

abstract：:Several cDNAs encoding an isoform of the alpha 1 subunit of the voltage-dependent calcium channel were isolated from rat brain cDNA libraries. The complete nucleotide sequence of 6975 bp encodes a protein of 1634 amino acids, which corresponds to an Mr of 186,968. The protein exhibits 71% and 76% homology to skeletal ...

journal_title：Neuron

authors： Hui A,Ellinor PT,Krizanova O,Wang JJ,Diebold RJ,Schwartz A

更新日期：1991-07-01 00:00:00

abstract：:Small conductance Ca(2+)-activated K(+) (SK) channels and voltage-gated A-type Kv4 channels shape dendritic excitatory postsynaptic potentials (EPSPs) in hippocampal CA1 pyramidal neurons. Synaptically evoked Ca(2+) influx through N-methyl-D-aspartate receptors (NMDARs) activates spine SK channels, reducing EPSPs and ...

journal_title：Neuron

authors： Wang K,Lin MT,Adelman JP,Maylie J

更新日期：2014-01-22 00:00:00

abstract：:The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...

journal_title：Neuron

authors： Smith AP,Stephan KE,Rugg MD,Dolan RJ

更新日期：2006-02-16 00:00:00

abstract：:Persistent neural activity that outlasts an initial stimulus is thought to provide a mechanism for the transient storage of memory. In this issue of Neuron, Fransén et al. identify important principles for a cell-autonomous mechanism of graded persistent firing using an elegant combination of experimental and computat...

journal_title：Neuron

authors： Dudman JT,Siegelbaum SA

更新日期：2006-03-02 00:00:00

abstract：:Microglia are the immune cells of the brain. Here we show a massive infiltration of highly ramified and elongated microglia within the core of amyloid plaques in transgenic mouse models of Alzheimer's disease (AD). Many of these cells originate from the bone marrow, and the beta-amyloid-40 and -42 isoforms are able to...

journal_title：Neuron

authors： Simard AR,Soulet D,Gowing G,Julien JP,Rivest S

更新日期：2006-02-16 00:00:00

abstract：:Somatic mutation of the MTOR gene is a genetic etiology of focal malformations of cortical development. In this issue of Neuron, Park et al. (2018) identify defective autophagy-dependent ciliogenesis/Wnt signaling as an underlying mechanism affecting neuronal migration and cortical lamination. ...

journal_title：Neuron

authors： Di Nardo A,Sahin M

更新日期：2018-07-11 00:00:00

abstract：:Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form t...

journal_title：Neuron

authors： Franks KM,Isaacson JS

更新日期：2006-02-02 00:00:00

abstract：:mRNA coding for brain-derived neurotrophic factor (BDNF) has been detected in cultured L929 fibroblasts, rat dermal fibroblasts, and sciatic nerve Schwann cells, as well as in rat skin. Medium conditioned by cultured fibroblasts and Schwann cells also stimulates neurite growth from retinal explants and promotes the su...

journal_title：Neuron

authors： Acheson A,Barker PA,Alderson RF,Miller FD,Murphy RA

更新日期：1991-08-01 00:00:00

abstract：:The ability to classify visual objects into discrete categories ("friend" versus "foe"; "edible" versus "poisonous") is essential for survival and is a fundamental cognitive function. The cortical substrates that mediate this function, however, have not been identified in humans. To identify brain regions involved in ...

journal_title：Neuron

authors： Grinband J,Hirsch J,Ferrera VP

更新日期：2006-03-02 00:00:00

abstract：:Homomeric assembly of Kir5.1, an inward-rectifying K+ channel subunit, is believed to be nonfunctional, although the subunit exists abundantly in the brain. We show that HEK293T cells cotransfected with Kir5.1 and PSD-95 exhibit a Ba(2+)-sensitive inward-rectifying K+ current. Kir5.1 coexpressed with PSD-95 located on...

journal_title：Neuron

authors： Tanemoto M,Fujita A,Higashi K,Kurachi Y

更新日期：2002-04-25 00:00:00

abstract：:We have used the caged calcium compound DM-nitrophen to investigate the kinetics of calcium-dependent secretion in bovine chromaffin cells. Perfusion with partially calcium-loaded nitrophen often caused a loading transient--slow secretion for up to 1 min due to displacement of Ca2+ by cytoplasmic Mg2+. Flash photolysi...

journal_title：Neuron

authors： Neher E,Zucker RS

更新日期：1993-01-01 00:00:00

abstract：:Cortical GABAergic interneurons have essential roles for information processing and their dysfunction is implicated in neuropsychiatric disorders. Transcriptional codes are elucidating mechanisms of interneuron specification in the MGE (a subcortical progenitor zone), which regulate their migration, integration, and f...

journal_title：Neuron

authors： Vogt D,Hunt RF,Mandal S,Sandberg M,Silberberg SN,Nagasawa T,Yang Z,Baraban SC,Rubenstein JL

更新日期：2014-04-16 00:00:00

abstract：:We determined the cellular substrate for male courtship behavior by quasinatural and artificial stimulation of brain neurons. Activation of fruitless (fru)-expressing neurons via stimulation of thermosensitive dTrpA1 channels induced an entire series of courtship acts in male Drosophila placed alone without any courti...

journal_title：Neuron

authors： Kohatsu S,Koganezawa M,Yamamoto D

更新日期：2011-02-10 00:00:00

abstract：:Accurate perception of the actions and intentions of other people is essential for successful interactions in a social environment. Several cortical areas that support this process respond selectively in fMRI to static and dynamic displays of human bodies and faces. Here we apply pattern-analysis techniques to arrive ...

journal_title：Neuron

authors： Peelen MV,Wiggett AJ,Downing PE

更新日期：2006-03-16 00:00:00

abstract：:Neurotrophins and tyrosine receptor kinase (Trk) receptors are expressed in skeletal muscle, but it is unclear what functional role Trk-mediated signaling plays during postnatal life. Full-length TrkB (trkB.FL) as well as truncated TrkB (trkB.t1) were found to be localized primarily to the postsynaptic acetylcholine r...

journal_title：Neuron

authors： Gonzalez M,Ruggiero FP,Chang Q,Shi YJ,Rich MM,Kraner S,Balice-Gordon RJ

更新日期：1999-11-01 00:00:00

abstract：:The alpha subunit of a voltage-sensitive sodium channel characteristic of denervated rat skeletal muscle was cloned and characterized. The cDNA encodes a 2018 amino acid protein (SkM2) that is homologous to other recently cloned sodium channels, including a tetrodotoxin (TTX)-sensitive sodium channel from rat skeletal...

journal_title：Neuron

authors： Kallen RG,Sheng ZH,Yang J,Chen LQ,Rogart RB,Barchi RL

更新日期：1990-02-01 00:00:00

abstract：:The calcium-activated small conductance potassium channel SK3 plays an essential role in the regulation of dopamine neuron activity patterns. Here we demonstrate that expression of a human disease-related SK3 mutation (hSK3Δ) in dopamine neurons of mice disrupts the balance between tonic and phasic dopamine neuron act...

journal_title：Neuron

authors： Soden ME,Jones GL,Sanford CA,Chung AS,Güler AD,Chavkin C,Luján R,Zweifel LS

更新日期：2013-11-20 00:00:00

abstract：:Compelling evidence links amyloid beta (Aβ) peptide accumulation in the brains of Alzheimer's disease (AD) patients with the emergence of learning and memory deficits, yet a clear understanding of the events that drive this synaptic pathology are lacking. We present evidence that neurons exposed to Aβ are unable to fo...

journal_title：Neuron

authors： Zhao Y,Sivaji S,Chiang MC,Ali H,Zukowski M,Ali S,Kennedy B,Sklyar A,Cheng A,Guo Z,Reed AK,Kodali R,Borowski J,Frost G,Beukema P,Wills ZP

更新日期：2017-10-11 00:00:00

abstract：:Autism spectrum disorder (ASD) may arise from increased ratio of excitatory to inhibitory neurotransmission in the brain. Many pharmacological treatments have been tested in ASD, but only limited success has been achieved. Here we report that BTBR T(+)Itpr3(tf)/J (BTBR) mice, a model of idiopathic autism, have reduced...

journal_title：Neuron

authors： Han S,Tai C,Jones CJ,Scheuer T,Catterall WA

更新日期：2014-03-19 00:00:00

abstract：:Whether cognitive representations are better conceived as language-based, symbolic representations or perceptually related, analog representations is a subject of debate. If cognitive processes parallel perceptual processes, then fundamental psychophysical laws should hold for each. To test this, we analyzed both beha...

journal_title：Neuron

authors： Nieder A,Miller EK

更新日期：2003-01-09 00:00:00

abstract：:The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studies attempting to elucidate the underlying mechanism for this increased risk, how apoE4 influences AD onset and progression has yet to be proven. However, prevailing evide...

journal_title：Neuron

authors： Kim J,Basak JM,Holtzman DM

更新日期：2009-08-13 00:00:00

abstract：:Anteroposterior (AP) patterning in the vertebrate hindbrain is dependent upon the establishment of segmental domains of Hox expression. We investigated the mechanism that governs the early expression of Hoxb4 and found that transient signaling from the paraxial mesoderm induces expression in the hindbrain. Induction i...

journal_title：Neuron

authors： Gould A,Itasaki N,Krumlauf R

更新日期：1998-07-01 00:00:00

abstract：:Promises are one of the oldest human-specific psychological mechanisms fostering cooperation and trust. Here, we study the neural underpinnings of promise keeping and promise breaking. Subjects first make a promise decision (promise stage), then they anticipate whether the promise affects the interaction partner's dec...

journal_title：Neuron

authors： Baumgartner T,Fischbacher U,Feierabend A,Lutz K,Fehr E

更新日期：2009-12-10 00:00:00

abstract：:The role of cellular interactions in determining the fates of two identified motoneurons in the embryonic zebrafish was investigated by transplanting individual motoneurons from labeled donor embryos to unlabeled hosts. The results suggest that although these cells normally adopt different fates, they form an equivale...

journal_title：Neuron

authors： Eisen JS

更新日期：1992-02-01 00:00:00

abstract：:Agonist-induced suppression of current in voltage-gated Ca2+ channels was studied in rat sympathetic neurons. We have previously distinguished two intracellular signaling pathways used by muscarinic agonists to suppress neuronal Ca2+ current-one fast and membrane delimited, the other slow and acting via a diffusible s...

journal_title：Neuron

authors： Beech DJ,Bernheim L,Hille B

更新日期：1992-01-01 00:00:00

abstract：:Immortalized retinal neurons have been established in tissue culture from retinal tumors arising in transgenic mice. The mice carry the SV40 T-antigen under the control of 5' flanking sequences from the human phenylethanolamine N-methyltransferase (PNMT) gene in order to target oncogene expression to adrenergic cell t...

journal_title：Neuron

authors： Hammang JP,Baetge EE,Behringer RR,Brinster RL,Palmiter RD,Messing A

更新日期：1990-05-01 00:00:00

abstract：:The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3 ubiquitin ligases WW-Containing Proteins 1 and 2 (Wwp1 and Wwp2) are indispensable for proper polarization of developing neurons. We show that knockout of Wwp1 and...

journal_title：Neuron

authors： Ambrozkiewicz MC,Schwark M,Kishimoto-Suga M,Borisova E,Hori K,Salazar-Lázaro A,Rusanova A,Altas B,Piepkorn L,Bessa P,Schaub T,Zhang X,Rabe T,Ripamonti S,Rosário M,Akiyama H,Jahn O,Kobayashi T,Hoshino M,Tarabykin V,

更新日期：2018-12-05 00:00:00

abstract：:Experimental evidence shows that the inability to attribute mental states, such as desires and beliefs, to self and others (mentalizing) explains the social and communication impairments of individuals with autism. Brain imaging studies in normal volunteers highlight a circumscribed network that is active during menta...

journal_title：Neuron

authors： Frith U

更新日期：2001-12-20 00:00:00

abstract：:The differentiation of neuronal cell progenitors depends on complex interactions between intrinsic cellular programs and environmental cues. Such interactions have recently been explored using an immortalized sympathoadrenal progenitor cell line, MAH. These studies have revealed that depolarizing conditions, in combin...

journal_title：Neuron

authors： Ip NY,Boulton TG,Li Y,Verdi JM,Birren SJ,Anderson DJ,Yancopoulos GD

更新日期：1994-08-01 00:00:00

abstract：:Embryonic mouse neural tubes produce a variety of terminally differentiated cells in vitro, mostly neurons and glia. We report here that some of these cells differentiate into skeletal muscle cells. The possibility of mesoderm contamination was ruled out as follows. First, Dil+ muscle cells were present in cultures fr...

journal_title：Neuron

authors： Tajbakhsh S,Vivarelli E,Cusella-De Angelis G,Rocancourt D,Buckingham M,Cossu G

更新日期：1994-10-01 00:00:00