Abstract:
:mRNA coding for brain-derived neurotrophic factor (BDNF) has been detected in cultured L929 fibroblasts, rat dermal fibroblasts, and sciatic nerve Schwann cells, as well as in rat skin. Medium conditioned by cultured fibroblasts and Schwann cells also stimulates neurite growth from retinal explants and promotes the survival in culture of BDNF-responsive sensory neurons; biological activity is abolished by antibodies raised against NGF. These results suggest that molecules with BDNF-like activity may be produced by cells in the peripheral nervous system and that the BDNF-like activity in fibroblasts and Schwann cells is derived from molecules immunologically related to NGF. In support of this concept, antibodies against NGF have been found to reduce the biological activity of recombinant BDNF in culture and to cross-react with BDNF on Western blots.
journal_name
Neuronjournal_title
Neuronauthors
Acheson A,Barker PA,Alderson RF,Miller FD,Murphy RAdoi
10.1016/0896-6273(91)90265-2subject
Has Abstractpub_date
1991-08-01 00:00:00pages
265-75issue
2eissn
0896-6273issn
1097-4199pii
0896-6273(91)90265-2journal_volume
7pub_type
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