The cortical control of movement revisited.

abstract：:Social environment modulates learning through unknown mechanisms. Here, we report that a pheromone mixture that signals overcrowding inhibits C. elegans from learning to avoid pathogenic bacteria. We find that learning depends on the balanced signaling of two insulin-like peptides (ILPs), INS-16 and INS-4, which act r...

journal_title：Neuron

authors： Wu T,Duan F,Yang W,Liu H,Caballero A,Fernandes de Abreu DA,Dar AR,Alcedo J,Ch'ng Q,Butcher RA,Zhang Y

更新日期：2019-12-18 00:00:00

abstract：:Memory consolidation refers to the transformation over time of experience-dependent internal representations and their neurobiological underpinnings. The process is assumed to be embodied in synaptic and cellular modifications at brain circuits in which the memory is initially encoded and to proceed by recurrent react...

journal_title：Neuron

authors： Dudai Y,Karni A,Born J

更新日期：2015-10-07 00:00:00

abstract：:Much evidence indicates that prefrontal cortex plays an important role in long-term recognition memory processes. Here, we report primate prefrontal neuronal responses carrying information necessary for long-term visual recognition memory. The responses of many neurons signaled stimulus familiarity even when the perio...

journal_title：Neuron

authors： Xiang JZ,Brown MW

更新日期：2004-06-10 00:00:00

abstract：:The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3 ubiquitin ligases WW-Containing Proteins 1 and 2 (Wwp1 and Wwp2) are indispensable for proper polarization of developing neurons. We show that knockout of Wwp1 and...

journal_title：Neuron

authors： Ambrozkiewicz MC,Schwark M,Kishimoto-Suga M,Borisova E,Hori K,Salazar-Lázaro A,Rusanova A,Altas B,Piepkorn L,Bessa P,Schaub T,Zhang X,Rabe T,Ripamonti S,Rosário M,Akiyama H,Jahn O,Kobayashi T,Hoshino M,Tarabykin V,

更新日期：2018-12-05 00:00:00

abstract：:Successful visual navigation requires a sense of the geometry of the local environment. How do our brains extract this information from retinal images? Here we visually presented scenes with all possible combinations of five scene-bounding elements (left, right, and back walls; ceiling; floor) to human subjects during...

journal_title：Neuron

authors： Henriksson L,Mur M,Kriegeskorte N

更新日期：2019-07-03 00:00:00

abstract：:Plus end tracking proteins (+TIPS) bind to microtubules. Results reported by Lee et al. and Zhou et al. in this issue of Neuron demonstrate that, via intracellular pathways signaling to +TIPs, microtubules can be a direct target of guidance cues in steering growth cones and regulating axon elongation. ...

journal_title：Neuron

authors： Kalil K,Dent EW

更新日期：2004-06-24 00:00:00

abstract：:Which neurons in the brain "decide" to initiate particular behaviors in response to sensory information? In this issue of Neuron, two papers (Kohatsu et al. and von Philipsborn et al.) identify candidates in the courtship circuitry of Drosophila. The activity of these neurons is both regulated by sex pheromones and ne...

journal_title：Neuron

authors： Benton R

更新日期：2011-02-10 00:00:00

abstract：:The spatial distribution of large-scale functional networks on the cerebral cortex differs between individuals and is particularly variable in association networks that are responsible for higher-order cognition. However, it remains unknown how this functional topography evolves in development and supports cognition. ...

journal_title：Neuron

authors： Cui Z,Li H,Xia CH,Larsen B,Adebimpe A,Baum GL,Cieslak M,Gur RE,Gur RC,Moore TM,Oathes DJ,Alexander-Bloch AF,Raznahan A,Roalf DR,Shinohara RT,Wolf DH,Davatzikos C,Bassett DS,Fair DA,Fan Y,Satterthwaite TD

更新日期：2020-04-22 00:00:00

abstract：:In the hippocampus, gamma power modulation by the theta rhythm is interpreted as the signature of temporally coordinated inputs that reflect ongoing processing. In this issue of Neuron, Lopes-Dos-Santos et al. (2018) develop a new methodology demonstrating that theta cycles can be viewed as individual computational un...

journal_title：Neuron

authors： Bagur S,Benchenane K

更新日期：2018-11-21 00:00:00

abstract：:Mapping of the chromosomal location of genes essential for sweet and bitter taste and identification of the relevant G protein-coupled receptors reveals unanticipated complexity in taste signaling pathways. The distribution of sweet and bitter receptors suggests complete cellular segregation of these taste modalities....

journal_title：Neuron

authors： Lewcock JW,Reed RR

更新日期：2001-08-30 00:00:00

abstract：:The retina adapts to average light intensity but also to the range of light intensities (contrast). A study by Baccus and Meister, in this issue of Neuron, identifies three ways that ganglion cells and interneurons adapt to high contrast: shorten integration time, reduce gain, and depolarize. Only the depolarization d...

journal_title：Neuron

authors： Demb JB

更新日期：2002-12-05 00:00:00

abstract：:Action potentials initiate in the axon initial segment (AIS), a specialized compartment enriched with Na(+) and K(+) channels. Recently, we found that T- and R-type Ca(2+) channels are concentrated in the AIS, where they contribute to local subthreshold membrane depolarization and thereby influence action potential in...

journal_title：Neuron

authors： Bender KJ,Ford CP,Trussell LO

更新日期：2010-11-04 00:00:00

abstract：:Cytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the nervous system. As a consequence of this dual role, cytokines induced in response to maternal infection or prenatal hypoxia can profoundly imp...

journal_title：Neuron

authors： Deverman BE,Patterson PH

更新日期：2009-10-15 00:00:00

abstract：:Cell proliferation during successive stages of oligodendrocyte development was delineated in the rat brain and optic nerve. Surface antigens, A2B5, O4, and galactocerebroside (GalC) identified three cell populations emerging in sequence; the incorporation of bromodeoxyuridine into newly synthesized DNA identified the ...

journal_title：Neuron

authors： Gard AL,Pfeiffer SE

更新日期：1990-11-01 00:00:00

abstract：:Shaker potassium channels inactivate and recover from inactivation with multiple exponential components, suggesting the presence of multiple inactivation processes. We describe two different types of inactivation in Shaker potassium channels. N-type inactivation can occur as rapidly as a few milliseconds and has been ...

journal_title：Neuron

authors： Hoshi T,Zagotta WN,Aldrich RW

更新日期：1991-10-01 00:00:00

abstract：:Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...

journal_title：Neuron

authors： Okun M

更新日期：2020-01-22 00:00:00

abstract：:Sensory information is actively gathered by animals, but the synaptic mechanisms driving neuronal circuit function during active sensory processing are poorly understood. Here, we investigated the synaptically driven membrane potential dynamics during active whisker sensation using whole-cell recordings from layer 2/3...

journal_title：Neuron

authors： Crochet S,Poulet JF,Kremer Y,Petersen CC

更新日期：2011-03-24 00:00:00

abstract：:The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K...

journal_title：Neuron

authors： Jiang Y,Pico A,Cadene M,Chait BT,MacKinnon R

更新日期：2001-03-01 00:00:00

abstract：:Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays of neuronal survival and growth cone chemotropism. Mutational analysis indicates that coactivation of phospholipase C-gamma (PLC-gamma) and phosphoinositide 3-kinase (PI3-kinase) by specific ...

journal_title：Neuron

authors： Ming G,Song H,Berninger B,Inagaki N,Tessier-Lavigne M,Poo M

更新日期：1999-05-01 00:00:00

abstract：:Acetylcholinesterase (AChE) density at the neuromuscular junction of frog cutaneous pectoris muscle was determined by electron microscope autoradiography and biochemistry to be approximately 600 sites micron-2 of postsynaptic area, approximately 4-fold lower than all previous reports (mouse), whereas the hydrolytic tu...

journal_title：Neuron

authors： Anglister L,Stiles JR,Salpeter MM

更新日期：1994-04-01 00:00:00

abstract：:Vaccinia virus can be used to infect cells in the CNS of frogs, Xenopus laevis, and Rana pipiens, both in vivo and in vitro. In vivo infections were accomplished by injection of viral solution into the tectal ventricle of stage 40-48 tadpoles or by local injections into distinct neural regions. Infections with high ti...

journal_title：Neuron

authors： Wu GY,Zou DJ,Koothan T,Cline HT

更新日期：1995-04-01 00:00:00

abstract：:Respiration is a rhythmic activity as well as one that requires responsiveness to internal and external circumstances; both the rhythm and neuromodulatory responses of breathing are controlled by brainstem neurons in the preBötzinger complex (preBötC) and the retrotrapezoid nucleus (RTN), but the specific ion channels...

journal_title：Neuron

authors： Yeh SY,Huang WH,Wang W,Ward CS,Chao ES,Wu Z,Tang B,Tang J,Sun JJ,Esther van der Heijden M,Gray PA,Xue M,Ray RS,Ren D,Zoghbi HY

更新日期：2017-04-19 00:00:00

abstract：:Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...

journal_title：Neuron

authors： Niethammer M,Smith DS,Ayala R,Peng J,Ko J,Lee MS,Morabito M,Tsai LH

更新日期：2000-12-01 00:00:00

abstract：:Precise apposition of presynaptic and postsynaptic domains is a fundamental property of all neuronal circuits. Experiments in vitro suggest that Neuroligins and Neurexins function as key regulatory proteins in this process. In a genetic screen, we recovered several mutant alleles of Drosophila neuroligin 1 (dnlg1) tha...

journal_title：Neuron

authors： Banovic D,Khorramshahi O,Owald D,Wichmann C,Riedt T,Fouquet W,Tian R,Sigrist SJ,Aberle H

更新日期：2010-06-10 00:00:00

abstract：:The stabilization of learned information into long-term memories requires new gene expression. CREB binding protein (CBP) is a coactivator of transcription that can be independently regulated in neurons. CBP functions both as a platform for recruiting other required components of the transcriptional machinery and as a...

journal_title：Neuron

authors： Korzus E,Rosenfeld MG,Mayford M

更新日期：2004-06-24 00:00:00

abstract：:Homomeric assembly of Kir5.1, an inward-rectifying K+ channel subunit, is believed to be nonfunctional, although the subunit exists abundantly in the brain. We show that HEK293T cells cotransfected with Kir5.1 and PSD-95 exhibit a Ba(2+)-sensitive inward-rectifying K+ current. Kir5.1 coexpressed with PSD-95 located on...

journal_title：Neuron

authors： Tanemoto M,Fujita A,Higashi K,Kurachi Y

更新日期：2002-04-25 00:00:00

abstract：:Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilateral...

journal_title：Neuron

authors： Dougherty KJ,Zagoraiou L,Satoh D,Rozani I,Doobar S,Arber S,Jessell TM,Kiehn O

更新日期：2013-11-20 00:00:00

abstract：:Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task,...

journal_title：Neuron

authors： Etkin A,Egner T,Peraza DM,Kandel ER,Hirsch J

更新日期：2006-09-21 00:00:00

abstract：:Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's disease (AD) bring cholesterol to the forefront of AD research. Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and t...

journal_title：Neuron

authors： Wolozin B

更新日期：2004-01-08 00:00:00

abstract：:The size of the movement and the molecular identity of the moving parts of the voltage sensor of a voltage-gated ion channel are debated. In the helical-screw model, the positively charged fourth transmembrane segment S4 slides and rotates along negative counter charges in S2 and S3, while in the paddle model, S4 carr...

journal_title：Neuron

authors： Broomand A,Elinder F

更新日期：2008-09-11 00:00:00