Abstract：
:Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct G(beta)gamma modulation of Ca2+ channels, a slower Galpha(q/11)-mediated mechanism has remained enigmatic despite intensive study. Recent work suggests that membrane phosphoinositides are crucial determinants of Ca2+ channel activity. Here, we discuss their role in Ca2+ channel modulation and the leading theories that seek to elucidate the underlying molecular details of the so-called "mysterious" G(q/11)-mediated signal.
journal_name
Neuronjournal_title
Neuronauthors
Delmas P,Coste B,Gamper N,Shapiro MSdoi
10.1016/j.neuron.2005.07.001subject
Has Abstractpub_date
2005-07-21 00:00:00pages
179-82issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(05)00562-3journal_volume
47pub_type
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