Abstract：
:Dopamine is essential to cognitive functions. However, despite abundant studies demonstrating that dopamine neuron activity is related to reinforcement and motivation, little is known about what signals dopamine neurons convey to promote cognitive processing. We therefore examined dopamine neuron activity in monkeys performing a delayed matching-to-sample task that required working memory and visual search. We found that dopamine neurons responded to task events associated with cognitive operations. A subset of dopamine neurons were activated by visual stimuli if the monkey had to store the stimuli in working memory. These neurons were located dorsolaterally in the substantia nigra pars compacta, whereas ventromedial dopamine neurons, some in the ventral tegmental area, represented reward prediction signals. Furthermore, dopamine neurons monitored visual search performance, becoming active when the monkey made an internal judgment that the search was successfully completed. Our findings suggest an anatomical gradient of dopamine signals along the dorsolateral-ventromedial axis of the ventral midbrain.
journal_name
Neuronjournal_title
Neuronauthors
Matsumoto M,Takada Mdoi
10.1016/j.neuron.2013.07.002subject
Has Abstractpub_date
2013-09-04 00:00:00pages
1011-24issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(13)00567-9journal_volume
79pub_type
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