Sodium channel gating: no margin for error.

abstract：:A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development. Here, we demonstrate that Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and...

journal_title：Neuron

authors： D'Arcangelo G,Homayouni R,Keshvara L,Rice DS,Sheldon M,Curran T

更新日期：1999-10-01 00:00:00

abstract：:Using somatic cell nuclear transfer, Hazen et al. (2016) examined clonally expanded single neurons for mutations and found ∼100 mutations from a variety of classes. Post-mitotic mutations in individual neurons represent an exploratory direction for finding fundamental origins of neurodegeneration. ...

journal_title：Neuron

authors： Kosik KS

更新日期：2016-03-16 00:00:00

abstract：:Neuroscience relies on techniques for imaging the structure and dynamics of neural circuits, but the cell bodies of individual neurons are often obscured by overlapping fluorescence from axons and dendrites in surrounding neuropil. Here, we describe two strategies for using the ribosome to restrict the expression of f...

journal_title：Neuron

authors： Chen Y,Jang H,Spratt PWE,Kosar S,Taylor DE,Essner RA,Bai L,Leib DE,Kuo TW,Lin YC,Patel M,Subkhangulova A,Kato S,Feinberg EH,Bender KJ,Knight ZA,Garrison JL

更新日期：2020-08-05 00:00:00

abstract：:Selective synaptic and axonal degeneration are critical aspects of both brain development and neurodegenerative disease. Inhibition of caspase signaling in neurons is a potential therapeutic strategy for neurodegenerative disease, but no neuron-specific modulators of caspase signaling have been described. Using a mass...

journal_title：Neuron

authors： Hertz NT,Adams EL,Weber RA,Shen RJ,O'Rourke MK,Simon DJ,Zebroski H,Olsen O,Morgan CW,Mileur TR,Hitchcock AM,Sinnott Armstrong NA,Wainberg M,Bassik MC,Molina H,Wells JA,Tessier-Lavigne M

更新日期：2019-08-07 00:00:00

abstract：:The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by wh...

journal_title：Neuron

authors： McGinley MJ,Vinck M,Reimer J,Batista-Brito R,Zagha E,Cadwell CR,Tolias AS,Cardin JA,McCormick DA

更新日期：2015-09-23 00:00:00

abstract：:We have made little recent progress developing effective new treatments for neuropsychiatric and neurodevelopmental disorders. Novel molecular mechanisms have been identified, but have not translated into the clinic. We suggest an alternative: combinations of treatments targeting different aspects of final common path...

journal_title：Neuron

authors： Murphy DG,Goldman M,Loth E,Spooren W

更新日期：2014-11-05 00:00:00

abstract：:How primates perceive objects along with their detailed features remains a mystery. This ability to make fine visual discriminations depends upon a high-acuity analysis of spatial frequency (SF) along the visual hierarchy from V1 to inferotemporal cortex. By studying the transformation of SF across macaque parafoveal ...

journal_title：Neuron

authors： Lu Y,Yin J,Chen Z,Gong H,Liu Y,Qian L,Li X,Liu R,Andolina IM,Wang W

更新日期：2018-04-18 00:00:00

abstract：:The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hip...

journal_title：Neuron

authors： Siapas AG,Lubenov EV,Wilson MA

更新日期：2005-04-07 00:00:00

abstract：:Understanding the neural basis of adaptation (repetition suppression) is critical for interpreting fMRI-adaptation experiments. Sawamura and colleagues provide a critical stepping-stone by elucidating the relation between neural adaptation and response selectivity. They find some cross-adaptation by two different stim...

journal_title：Neuron

authors： Grill-Spector K

更新日期：2006-01-19 00:00:00

abstract：:Does our understanding of the human brain remain incomplete without a proper understanding of how the brain processes music? Here, the author makes a passionate plea for the use of music in the investigation of human emotion and its brain correlates, arguing that music can change activity in all brain structures assoc...

journal_title：Neuron

authors： Koelsch S

更新日期：2018-06-27 00:00:00

abstract：:In this perspective I tell the story (albeit a clearly abridged version) of how our knowledge of ion conduction through ion channels has evolved from a purely electrical concept to a structural dynamics view of ions interacting with a membrane protein. Our progress in this field has shown steady growth over the years ...

journal_title：Neuron

authors： Bezanilla F

更新日期：2008-11-06 00:00:00

abstract：:Outer hair cells (OHCs) provide amplification in the mammalian cochlea using somatic force generation underpinned by voltage-dependent conformational changes of the motor protein prestin. However, prestin must be gated by changes in membrane potential on a cycle-by-cycle basis and the periodic component of the recepto...

journal_title：Neuron

authors： Johnson SL,Beurg M,Marcotti W,Fettiplace R

更新日期：2011-06-23 00:00:00

abstract：:Accumulation of beta-amyloid protein (Abeta) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue of Neuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Abeta levels are directly modulated by neurona...

journal_title：Neuron

authors： Schroeder BE,Koo EH

更新日期：2005-12-22 00:00:00

abstract：:Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limit...

journal_title：Neuron

authors： Mennerick S,Matthews G

更新日期：1996-12-01 00:00:00

abstract：:We have identified factors that control precise motor timing by studying learning in smooth pursuit eye movements. Monkeys tracked a target that moved horizontally for a fixed time interval before changing direction through the addition of a vertical component of motion. After repeated presentations of the same target...

journal_title：Neuron

authors： Medina JF,Carey MR,Lisberger SG

更新日期：2005-01-06 00:00:00

abstract：:Although deep brain electrical stimulation can alleviate the motor symptoms of Parkinson disease (PD), just a small fraction of patients with PD can take advantage of this procedure due to its invasive nature. A significantly less invasive method--epidural spinal cord stimulation (SCS)--has been suggested as an altern...

journal_title：Neuron

authors： Santana MB,Halje P,Simplício H,Richter U,Freire MAM,Petersson P,Fuentes R,Nicolelis MAL

更新日期：2014-11-19 00:00:00

abstract：:Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...

journal_title：Neuron

authors： Kounios J,Smith RW,Yang W,Bachman P,D'Esposito M

更新日期：2001-01-01 00:00:00

abstract：:The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, neurotransmitter release, and potentiated the size, but not the properties, of ...

journal_title：Neuron

authors： Kaeser PS,Deng L,Chávez AE,Liu X,Castillo PE,Südhof TC

更新日期：2009-10-29 00:00:00

abstract：:A fundamental property of neuronal circuits is the ability to adapt to altered sensory inputs. It is well established that the functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, the degree to which structural plasticity in inhibitory neu...

journal_title：Neuron

authors： Keck T,Scheuss V,Jacobsen RI,Wierenga CJ,Eysel UT,Bonhoeffer T,Hübener M

更新日期：2011-09-08 00:00:00

abstract：:For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ...

journal_title：Neuron

authors： McAllister AK,van de Water J

更新日期：2009-10-15 00:00:00

abstract：:Quantitative differences in cadherin activity have been proposed to play important roles in patterning connections between pre- and postsynaptic neurons. However, no examples of such a function have yet been described, and the mechanisms that would allow such differences to direct growth cones to specific synaptic tar...

journal_title：Neuron

authors： Chen PL,Clandinin TR

更新日期：2008-04-10 00:00:00

abstract：:In this issue of Neuron, Espuny-Camacho et al. (2017) generate a humanized Alzheimer's disease (AD) model that reveals species-specific vulnerability of human neurons to AD pathology. This model provides key insights for disease mechanism and therapeutic discovery for AD. ...

journal_title：Neuron

authors： Cahill MK,Huang EJ

更新日期：2017-03-08 00:00:00

abstract：:Gene expression may occur in unexpected ectopic sites when diverse genetic elements are juxtaposed as chimeric genes in transgenic mice. To determine the specific contribution of the promoter and reporter gene in ectopic expression, we have analyzed the expression of 14 different fusion genes in transgenic mice. Chime...

journal_title：Neuron

authors： Russo AF,Crenshaw EB 3rd,Lira SA,Simmons DM,Swanson LW,Rosenfeld MG

更新日期：1988-06-01 00:00:00

abstract：:AMPA receptors are thought to be a tetrameric assembly of the subunits GluR1-4. We have examined whether two coexpressed subunits (GluR1/2) combine at random to form channels, or preferentially assemble with a specific stoichiometry and spatial configuration. The subunits carried markers controlling ion permeation and...

journal_title：Neuron

authors： Mansour M,Nagarajan N,Nehring RB,Clements JD,Rosenmund C

更新日期：2001-12-06 00:00:00

abstract：:Protein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain elusive. We combined pharmacological manipulations of kinase and phosphatase activities with mutational studies on the exocytotic machinery driving fusion of catecholamine-containing vesicles from chromaffin cells. We found t...

journal_title：Neuron

authors： Nagy G,Reim K,Matti U,Brose N,Binz T,Rettig J,Neher E,Sørensen JB

更新日期：2004-02-05 00:00:00

abstract：:The biologically active photoproduct of rhodopsin, metarhodopsin II (M II), exists in a pH-sensitive equilibrium with its precursor, metarhodopsin I (M I). Increasing acidity favors M II, with the midpoint of the pH titration curve at pH 6.4. To test the long-standing proposal that histidine protonation regulates this...

journal_title：Neuron

authors： Weitz CJ,Nathans J

更新日期：1992-03-01 00:00:00

abstract：:Olfaction is a vitally important sense for all animals. There are striking similarities between species in the organization of the olfactory pathway, from the nature of the odorant receptor proteins, to perireceptor processes, to the organization of the olfactory CNS, through odor-guided behavior and memory. These com...

journal_title：Neuron

authors： Ache BW,Young JM

更新日期：2005-11-03 00:00:00

abstract：:Opioids are commonly used as analgesics for severe pain, but their addictive potential has sparked a misuse epidemic. In this issue of Neuron, Keyes et al. (2020) examine the contributions of distinct paraventricular thalamus (PVT) outputs to contextual opioid memories. They identify a PVT→NAc→LH circuit essential for...

journal_title：Neuron

authors： Pribiag H,Lim BK

更新日期：2020-09-23 00:00:00

abstract：:During synaptic development, proteins aggregate at specialized pre- and postsynaptic structures. Mechanisms that mediate protein clustering at these sites remain unknown. To investigate this process, we analyzed synaptic targeting of a postsynaptic density protein, PSD-95, by expressing green fluorescent protein- (GFP...

journal_title：Neuron

authors： Craven SE,El-Husseini AE,Bredt DS

更新日期：1999-03-01 00:00:00

abstract：:In uncertain environments, decision-makers must balance two goals: they must "exploit" rewarding options but also "explore" in order to discover rewarding alternatives. Exploring and exploiting necessarily change how the brain responds to identical stimuli, but little is known about how these states, and transitions b...

journal_title：Neuron

authors： Ebitz RB,Albarran E,Moore T

更新日期：2018-01-17 00:00:00