Abstract:
:Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulated nuclear import of HDAC5 requires a signaling mechanism that involves transient, protein phosphatase 2A (PP2A)-dependent dephosphorylation of a Cdk5 site (S279) found within the HDAC5 nuclear localization sequence. Dephosphorylation of HDAC5 increases its nuclear accumulation, by accelerating its nuclear import rate and reducing its nuclear export rate. Importantly, we show that dephosphorylation of HDAC5 S279 in the nucleus accumbens suppresses the development, but not expression, of cocaine reward behavior in vivo. Together, our findings reveal a molecular mechanism by which cocaine regulates HDAC5 function to antagonize the rewarding impact of cocaine, likely by putting a brake on drug-stimulated gene expression that supports drug-induced behavioral changes.
journal_name
Neuronjournal_title
Neuronauthors
Taniguchi M,Carreira MB,Smith LN,Zirlin BC,Neve RL,Cowan CWdoi
10.1016/j.neuron.2011.10.032subject
Has Abstractpub_date
2012-01-12 00:00:00pages
108-20issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(11)00996-2journal_volume
73pub_type
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