Response and habituation of the human amygdala during visual processing of facial expression.

abstract：:Voltage-gated calcium channels couple depolarization of the cell-surface membrane to entry of calcium, which triggers secretion, contraction, neurotransmission, gene expression, and other physiological responses. They are encoded by ten genes, which generate three voltage-gated calcium channel subfamilies: CaV1; CaV2;...

journal_title：Neuron

authors： Nanou E,Catterall WA

更新日期：2018-05-02 00:00:00

abstract：:Measuring electrical activity in large numbers of cells with high spatial and temporal resolution is a fundamental problem for the study of neural development and information processing. To address this problem, we have constructed a novel, genetically encoded probe that can be used to measure transmembrane voltage in...

journal_title：Neuron

authors： Siegel MS,Isacoff EY

更新日期：1997-10-01 00:00:00

abstract：:The visual cortex represents stimuli through the activity of neuronal populations. We measured the evolution of this activity in space and time by imaging voltage-sensitive dyes in cat area V1. Contrast-reversing stimuli elicit responses that oscillate at twice the stimulus frequency, indicating that signals originate...

journal_title：Neuron

authors： Benucci A,Frazor RA,Carandini M

更新日期：2007-07-05 00:00:00

abstract：:Calcium-activated potassium channels were expressed in Xenopus oocytes by injection of RNA transcribed in vitro from complementary DNAs derived from the slo locus of Drosophila melanogaster. Many cDNAs were found that encode closely related proteins of about 1200 aa. The predicted sequences of these proteins differ by...

journal_title：Neuron

authors： Adelman JP,Shen KZ,Kavanaugh MP,Warren RA,Wu YN,Lagrutta A,Bond CT,North RA

更新日期：1992-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many years to decades. Five AD biomarkers are sufficiently validated to have been incorporated into clinical diagnostic criteria and commonly used in...

journal_title：Neuron

authors： Jack CR Jr,Holtzman DM

更新日期：2013-12-18 00:00:00

abstract：:NMDA receptor subunit composition varies throughout the brain, providing molecular diversity in NMDA receptor function. The NR2 subunits (NR2A-D) in large part dictate the distinct functional properties of NMDA receptors and differentially regulate receptor trafficking. Although the NR2C subunit is highly enriched in ...

journal_title：Neuron

authors： Chen BS,Roche KW

更新日期：2009-05-28 00:00:00

abstract：:Oxytocin (OT) release by axonal terminals onto the central nucleus of the amygdala exerts anxiolysis. To investigate which subpopulation of OT neurons contributes to this effect, we developed a novel method: virus-delivered genetic activity-induced tagging of cell ensembles (vGATE). With the vGATE method, we identifie...

journal_title：Neuron

authors： Hasan MT,Althammer F,Silva da Gouveia M,Goyon S,Eliava M,Lefevre A,Kerspern D,Schimmer J,Raftogianni A,Wahis J,Knobloch-Bollmann HS,Tang Y,Liu X,Jain A,Chavant V,Goumon Y,Weislogel JM,Hurlemann R,Herpertz SC,Pitzer

更新日期：2019-07-03 00:00:00

abstract：:The behavioral expression of fear ranges from active, cognitive responses to passive, freezing-like reactions. In this issue of Neuron, Gozzi, Jain, and colleagues suggest that neurons in the central amygdala orchestrate output signals toward either the brainstem or cholinergic basal forebrain and thereby can shift fe...

journal_title：Neuron

authors： Pape HC

更新日期：2010-08-26 00:00:00

abstract：:Classic studies of spatial attention assumed that its neural and behavioral effects were continuous over time. Recent behavioral studies have instead revealed that spatial attention leads to alternating periods of heightened or diminished perceptual sensitivity. Yet, the neural basis of these rhythmic fluctuations has...

journal_title：Neuron

authors： Fiebelkorn IC,Pinsk MA,Kastner S

更新日期：2018-08-22 00:00:00

abstract：:The inner ear's performance is greatly enhanced by an active process defined by four features: amplification, frequency selectivity, compressive nonlinearity, and spontaneous otoacoustic emission. These characteristics emerge naturally if the mechanoelectrical transduction process operates near a dynamical instability...

journal_title：Neuron

authors： Hudspeth AJ

更新日期：2008-08-28 00:00:00

abstract：:We have determined the sequences of isoforms of human tau protein, which differ from previously reported forms by insertions of 29 or 58 amino acids in the amino-terminal region. Complementary DNA cloning shows that the insertions occur in combination with both three and four tandem repeats. RNAase protection assays i...

journal_title：Neuron

authors： Goedert M,Spillantini MG,Jakes R,Rutherford D,Crowther RA

更新日期：1989-10-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heritable, common neurodevelopmental disorder with diverse genetic causes. Several studies have implicated protein synthesis as one among several of its potential convergent mechanisms. We originally identified Janus kinase and microtubule-interacting protein 1 (JAKMIP1) as differen...

journal_title：Neuron

authors： Berg JM,Lee C,Chen L,Galvan L,Cepeda C,Chen JY,Peñagarikano O,Stein JL,Li A,Oguro-Ando A,Miller JA,Vashisht AA,Starks ME,Kite EP,Tam E,Gdalyahu A,Al-Sharif NB,Burkett ZD,White SA,Fears SC,Levine MS,Wohlschlegel

更新日期：2015-12-16 00:00:00

abstract：:Light plays a pivotal role in the regulation of affective behaviors. However, the precise circuits that mediate the impact of light on depressive-like behaviors are not well understood. Here, we show that light influences depressive-like behaviors through a disynaptic circuit linking the retina and the lateral habenul...

journal_title：Neuron

authors： Huang L,Xi Y,Peng Y,Yang Y,Huang X,Fu Y,Tao Q,Xiao J,Yuan T,An K,Zhao H,Pu M,Xu F,Xue T,Luo M,So KF,Ren C

更新日期：2019-04-03 00:00:00

abstract：:NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor-expressing cells, and the majority of native receptors are triheteromers containing two GluN1 and two different GluN2. In contrast to diheterome...

journal_title：Neuron

authors： Hansen KB,Ogden KK,Yuan H,Traynelis SF

更新日期：2014-03-05 00:00:00

abstract：:The hippocampus frequently replays memories of past experiences during sharp-wave ripple (SWR) events. These events can represent spatial trajectories extending from the animal's current location to distant locations, suggesting a role in the evaluation of upcoming choices. While SWRs have been linked to learning and ...

journal_title：Neuron

authors： Singer AC,Carr MF,Karlsson MP,Frank LM

更新日期：2013-03-20 00:00:00

abstract：:Genetic deletion of fragile X mental retardation protein (FMRP) has been shown to enhance mGluR-dependent long-term depression (LTD). Herein, we demonstrate that mGluR-LTD induces a transient, translation-dependent increase in FMRP that is rapidly degraded by the ubiquitin-proteasome pathway. Moreover, proteasome inhi...

journal_title：Neuron

authors： Hou L,Antion MD,Hu D,Spencer CM,Paylor R,Klann E

更新日期：2006-08-17 00:00:00

abstract：:New technologies to probe the nervous system are propelling innovation and discovery at blinding speed, but are our trainees prepared to maximize this power? The growing role of engineering in research, such as materials, computing, electronics, and devices, compels us to rethink neuroscience education. Core technolog...

journal_title：Neuron

authors： Litt B

更新日期：2015-04-08 00:00:00

abstract：:The production of new neurons in the adult hippocampus is exquisitely regulated, and alterations in this process may underlie both normal and pathological hippocampal function. In this issue of Neuron, Tozuka et al. describe electrophysiological recordings that target proliferating progenitor cells in adult mouse hipp...

journal_title：Neuron

authors： Deisseroth K,Malenka RC

更新日期：2005-09-15 00:00:00

abstract：:The combination of patch-clamp and molecular biology techniques has made it possible to characterize the pharmacological and biophysical properties of ion channels in single neurons and to screen for expression of specific mRNAs in the same cell. Following whole-cell recording, the cytoplasm of the cell is harvested, ...

journal_title：Neuron

authors： Sucher NJ,Deitcher DL

更新日期：1995-06-01 00:00:00

abstract：:The regulation of quantal size through pre- rather than postsynaptic mechanisms has recently received considerable attention as a potential mechanism for plasticity. Vesicular transporters catalyze the filling of synaptic vesicles with transmitter and are thus potential substrates for such presynaptic regulation. In t...

journal_title：Neuron

authors： Hnasko TS,Edwards RH

更新日期：2006-09-07 00:00:00

abstract：:Ionic currents were recorded from Xenopus oocytes injected with RNA isolated from chick or mouse brain. Three currents were studied: a rapid tetrodotoxin-sensitive Na+ current (Ina), an early outward K+ current sensitive to 4-aminopyridine (IA), and an inward current activated by the excitatory amino acid receptor ago...

journal_title：Neuron

authors： Lotan I,Volterra A,Dash P,Siegelbaum SA,Goelet P

更新日期：1988-12-01 00:00:00

abstract：:Ultrasound has received widespread attention as an emerging technology for targeted, non-invasive neuromodulation based on its ability to evoke electrophysiological and motor responses in animals. However, little is known about the spatiotemporal pattern of ultrasound-induced brain activity that could drive these resp...

journal_title：Neuron

authors： Sato T,Shapiro MG,Tsao DY

更新日期：2018-06-06 00:00:00

abstract：:In nerve terminals, residual Ca(2+) remaining from previous activity can cause facilitation of transmitter release by a mechanism that is still under debate. Here we show that the intracellular Ca(2+) sensitivity of transmitter release at the calyx of Held is largely unchanged during facilitation, which leaves an incr...

journal_title：Neuron

authors： Felmy F,Neher E,Schneggenburger R

更新日期：2003-03-06 00:00:00

abstract：:N-type calcium channels play a dominant role in controlling synaptic transmission in many peripheral neurons. Transmitter release from mammalian central nerve terminals, however, is relatively resistant to the N channel antagonist omega-conotoxin GVIA. We studied the sensitivity of glutamatergic synaptic transmission ...

journal_title：Neuron

authors： Luebke JI,Dunlap K,Turner TJ

更新日期：1993-11-01 00:00:00

abstract：:Application of Clostridium difficile toxin B, an inhibitor of the Rho family of GTPases, at the Aplysia sensory to motor neuron synapse blocks long-term facilitation and the associated growth of new sensory neuron varicosities induced by repeated pulses of serotonin (5-HT). We have isolated cDNAs encoding Aplysia Rho,...

journal_title：Neuron

authors： Udo H,Jin I,Kim JH,Li HL,Youn T,Hawkins RD,Kandel ER,Bailey CH

更新日期：2005-03-24 00:00:00

abstract：:The Fragile X mental retardation-1 (Fmr1) gene encodes a multifunctional protein, FMRP, with intrinsic RNA binding activity. We have developed an approach, antibody-positioned RNA amplification (APRA), to identify the RNA cargoes associated with the in vivo configured FMRP messenger ribonucleoprotein (mRNP) complex. U...

journal_title：Neuron

authors： Miyashiro KY,Beckel-Mitchener A,Purk TP,Becker KG,Barret T,Liu L,Carbonetto S,Weiler IJ,Greenough WT,Eberwine J

更新日期：2003-02-06 00:00:00

abstract：:Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells ...

journal_title：Neuron

authors： Eljaschewitsch E,Witting A,Mawrin C,Lee T,Schmidt PM,Wolf S,Hoertnagl H,Raine CS,Schneider-Stock R,Nitsch R,Ullrich O

更新日期：2006-01-05 00:00:00

abstract：:Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven ...

journal_title：Neuron

authors： Levin N,Dumoulin SO,Winawer J,Dougherty RF,Wandell BA

更新日期：2010-01-14 00:00:00

abstract：:To study the effect of cell type-restricted hamster PrP expression on susceptibility to the hamster scrapie agent, we generated transgenic mice using a 1 kb hamster cDNA clone containing the 0.76 kb HPrP open reading frame under control of the neuron-specific enolase promoter. In these mice, expression of HPrP was det...

journal_title：Neuron

authors： Race RE,Priola SA,Bessen RA,Ernst D,Dockter J,Rall GF,Mucke L,Chesebro B,Oldstone MB

更新日期：1995-11-01 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key modulators of neuronal activity by providing the depolarizing cation current I(h) involved in rhythmogenesis, dendritic integration, and synaptic transmission. These tasks critically depend on the availability of HCN channels, which is dynamica...

journal_title：Neuron

authors： Zolles G,Wenzel D,Bildl W,Schulte U,Hofmann A,Müller CS,Thumfart JO,Vlachos A,Deller T,Pfeifer A,Fleischmann BK,Roeper J,Fakler B,Klöcker N

更新日期：2009-06-25 00:00:00