JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.

abstract：:Memory decline in aging results from multiple factors that influence both executive function and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems are preferentially vulnerable to white matter change, atrophy, and certain forms of neurotransmitter depletion. Frontal-striatal change ma...

journal_title：Neuron

authors： Buckner RL

更新日期：2004-09-30 00:00:00

abstract：:The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in inform...

journal_title：Neuron

authors： Jackman SL,Regehr WG

更新日期：2017-05-03 00:00:00

abstract：:The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, neurotransmitter release, and potentiated the size, but not the properties, of ...

journal_title：Neuron

authors： Kaeser PS,Deng L,Chávez AE,Liu X,Castillo PE,Südhof TC

更新日期：2009-10-29 00:00:00

abstract：:According to economic theories, preference for one item over others reveals its rank value on a common scale. Previous studies identified brain regions encoding such values. Here we verify that these regions can valuate various categories of objects and further test whether they still express preferences when attentio...

journal_title：Neuron

authors： Lebreton M,Jorge S,Michel V,Thirion B,Pessiglione M

更新日期：2009-11-12 00:00:00

abstract：:Cytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the nervous system. As a consequence of this dual role, cytokines induced in response to maternal infection or prenatal hypoxia can profoundly imp...

journal_title：Neuron

authors： Deverman BE,Patterson PH

更新日期：2009-10-15 00:00:00

abstract：:Advances in defining mechanisms of cortical development have been paralleled in recent years by an intense interest in translating these findings into greater insight of both childhood- and adult-onset cognitive and mental health disorders of developmental etiology. Successful integration of basic and clinical finding...

journal_title：Neuron

authors： Levitt P

更新日期：2005-05-05 00:00:00

abstract：:Bcl-2 is a major regulator of programmed cell death, a critical process in shaping the developing nervous system. To assess whether Bcl-2 is involved in regulating neuronal survival and in mediating the neuroprotective action of neurotrophic factors, we generated Bcl-2-deficient mice. At birth, the number of facial mo...

journal_title：Neuron

authors： Michaelidis TM,Sendtner M,Cooper JD,Airaksinen MS,Holtmann B,Meyer M,Thoenen H

更新日期：1996-07-01 00:00:00

abstract：:In the visual cortex of many mammals, orientation preference changes smoothly along the cortical surface, with the exception of singularities such as pinwheels and fractures. The reason for the existence of these singularities has remained elusive, suggesting that they are developmental artifacts. We show that singula...

journal_title：Neuron

authors： Koulakov AA,Chklovskii DB

更新日期：2001-02-01 00:00:00

abstract：:Long-term memory and synaptic plasticity are thought to require the synthesis of new proteins at activated synapses. The CPEB family of RNA binding proteins, including Drosophila Orb2, has been implicated in this process. The precise mechanism by which these molecules regulate memory formation is however poorly unders...

journal_title：Neuron

authors： Krüttner S,Stepien B,Noordermeer JN,Mommaas MA,Mechtler K,Dickson BJ,Keleman K

更新日期：2012-10-18 00:00:00

abstract：:In the olfactory bulb of vertebrates or the homologous antennal lobe of insects, odor quality is represented by stereotyped patterns of neuronal activity that are reproducible within and between individuals. Using optical imaging to monitor synaptic activity in the Drosophila antennal lobe, we show here that classical...

journal_title：Neuron

authors： Yu D,Ponomarev A,Davis RL

更新日期：2004-05-13 00:00:00

abstract：:Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...

journal_title：Neuron

authors： Mitchell SJ,Silver RA

更新日期：2003-05-08 00:00:00

abstract：:Predictive coding posits that neural systems make forward-looking predictions about incoming information. Neural signals contain information not about the currently perceived stimulus, but about the difference between the observed and the predicted stimulus. We propose to extend the predictive coding framework from hi...

journal_title：Neuron

authors： Koster-Hale J,Saxe R

更新日期：2013-09-04 00:00:00

abstract：:Miniature synaptic currents have long been known to represent random transmitter release under resting conditions, but much remains to be learned about their nature and function in central synapses. In this work, we describe a new class of miniature currents ("preminis") that arise by the autocrine activation of axona...

journal_title：Neuron

authors： Trigo FF,Bouhours B,Rostaing P,Papageorgiou G,Corrie JE,Triller A,Ogden D,Marty A

更新日期：2010-04-29 00:00:00

abstract：:The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent ...

journal_title：Neuron

authors： Lee SJ,Montell C

更新日期：2004-07-08 00:00:00

abstract：:Self-consciousness has mostly been approached by philosophical enquiry and not by empirical neuroscientific study, leading to an overabundance of diverging theories and an absence of data-driven theories. Using robotic technology, we achieved specific bodily conflicts and induced predictable changes in a fundamental a...

journal_title：Neuron

authors： Ionta S,Heydrich L,Lenggenhager B,Mouthon M,Fornari E,Chapuis D,Gassert R,Blanke O

更新日期：2011-04-28 00:00:00

abstract：:Traditional studies of neuroanatomical connections require injection of tracer compounds into living brains, then histology of the postmortem tissue. Here, we describe and validate a compound that reveals neuronal connections in vivo, using MRI. The classic anatomical tracer CTB (cholera-toxin subunit-B) was conjugate...

journal_title：Neuron

authors： Wu CW,Vasalatiy O,Liu N,Wu H,Cheal S,Chen DY,Koretsky AP,Griffiths GL,Tootell RB,Ungerleider LG

更新日期：2011-04-28 00:00:00

abstract：:Agonist-induced suppression of current in voltage-gated Ca2+ channels was studied in rat sympathetic neurons. We have previously distinguished two intracellular signaling pathways used by muscarinic agonists to suppress neuronal Ca2+ current-one fast and membrane delimited, the other slow and acting via a diffusible s...

journal_title：Neuron

authors： Beech DJ,Bernheim L,Hille B

更新日期：1992-01-01 00:00:00

abstract：:Dopamine neurons in the ventral tegmental area (VTA) play an important role in the motivational systems underlying drug addiction, and recent work has suggested that they also release the excitatory neurotransmitter glutamate. To assess a physiological role for glutamate corelease, we disrupted the expression of vesic...

journal_title：Neuron

authors： Hnasko TS,Chuhma N,Zhang H,Goh GY,Sulzer D,Palmiter RD,Rayport S,Edwards RH

更新日期：2010-03-11 00:00:00

abstract：:Coordination between sequential steps in synaptic vesicle endocytosis, including clathrin coat formation, fission, and uncoating, appears to involve proteinprotein interactions. Here, we show that compounds that disrupt interactions of the SH3 domain of endophilin with dynamin and synaptojanin impair synaptic vesicle ...

journal_title：Neuron

authors： Gad H,Ringstad N,Löw P,Kjaerulff O,Gustafsson J,Wenk M,Di Paolo G,Nemoto Y,Crun J,Ellisman MH,De Camilli P,Shupliakov O,Brodin L

更新日期：2000-08-01 00:00:00

abstract：:Neuroimaging studies using diffusion tensor imaging (DTI) have revealed regions of cerebral white matter with decreased microstructural organization (lowerfractional anisotropy or FA) among poor readers. We examined whether 100 hr of intensive remedial instruction affected the white matter of 8- to 10-year-old poor re...

journal_title：Neuron

authors： Keller TA,Just MA

更新日期：2009-12-10 00:00:00

abstract：:We used fear conditioning, which is known to alter synaptic efficacy in lateral amygdala (LA), to study molecular mechanisms underlying long-term memory. Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated with GRB2 in LA significantly more in conditioned than in control rat...

journal_title：Neuron

authors： Lamprecht R,Farb CR,LeDoux JE

更新日期：2002-11-14 00:00:00

abstract：:Relatively little is known about the neural circuitry underlying sex-specific behaviors. We have expressed the feminizing gene transformer in genetically defined subregions of the brain of male Drosophila, and in particular within different domains of the mushroom bodies. Mushroom bodies are phylogenetically conserved...

journal_title：Neuron

authors： O'Dell KM,Armstrong JD,Yang MY,Kaiser K

更新日期：1995-07-01 00:00:00

abstract：:The TRPN1 ion channel has a role in both hearing and bristle mechanosensation in fruit flies and in proprioception in nematodes. In this issue of Neuron, two papers present evidence that TRPN1 is also required for proprioception in fruit fly larvae and that it is a bona fide mechanoreceptor channel for nematode feedin...

journal_title：Neuron

authors： Wilson RI,Corey DP

更新日期：2010-08-12 00:00:00

abstract：:Based on extrapolation from excitatory synapses, it is often assumed that depletion of the releasable pool of synaptic vesicles is the main factor underlying depression at inhibitory synapses. In this issue of Neuron, using subcellular patch-clamp recording from inhibitory presynaptic terminals, Kawaguchi and Sakaba (...

journal_title：Neuron

authors： Vandael DH,Espinoza C,Jonas P

更新日期：2015-03-18 00:00:00

abstract：:As a means to automate the three-dimensional histological analysis of brain tissue, we demonstrate the use of femtosecond laser pulses to iteratively cut and image fixed as well as fresh tissue. Cuts are accomplished with 1 to 10 microJ pulses to ablate tissue with micron precision. We show that the permeability, immu...

journal_title：Neuron

authors： Tsai PS,Friedman B,Ifarraguerri AI,Thompson BD,Lev-Ram V,Schaffer CB,Xiong Q,Tsien RY,Squier JA,Kleinfeld D

更新日期：2003-07-03 00:00:00

abstract：:Neuro-Education is a nascent discipline that seeks to blend the collective fields of neuroscience, psychology, cognitive science, and education to create a better understanding of how we learn and how this information can be used to create more effective teaching methods, curricula, and educational policy. Though stil...

journal_title：Neuron

authors： Carew TJ,Magsamen SH

更新日期：2010-09-09 00:00:00

abstract：:Synapses are lost during developmental synapse elimination. Until now, it has been impossible to follow elimination in the entirety of any neuron's branches and synapses. Using transgenic mice in which one or two of a muscle's motoneurons express variants of GFP, Keller-Peck et al. show in this issue of Neuron that el...

journal_title：Neuron

authors： Thompson WJ

更新日期：2001-08-16 00:00:00

abstract：:Neurons propagate information through circuits by integrating thousands of synaptic inputs to generate an action potential output. Inputs from different origins are often targeted to distinct regions of a neuron's dendritic tree, with synapses on more distal dendrites normally having a weaker influence on cellular out...

journal_title：Neuron

authors： Chevaleyre V,Siegelbaum SA

更新日期：2010-05-27 00:00:00

abstract：:Information processing by a sensory system is reflected in the changes in stimulus representation along its successive processing stages. We measured information content and stimulus-induced redundancy in the neural responses to a set of natural sounds in three successive stations of the auditory pathway-inferior coll...

journal_title：Neuron

authors： Chechik G,Anderson MJ,Bar-Yosef O,Young ED,Tishby N,Nelken I

更新日期：2006-08-03 00:00:00

abstract：:We examined the contribution of the amygdala to value signals within orbital prefrontal cortex (OFC) and medial prefrontal cortex (MFC). On each trial, monkeys chose between two stimuli that were associated with different quantities of reward. In intact monkeys, as expected, neurons in both OFC and MFC signaled the re...

journal_title：Neuron

authors： Rudebeck PH,Mitz AR,Chacko RV,Murray EA

更新日期：2013-12-18 00:00:00