Strong CA2 pyramidal neuron synapses define a powerful disynaptic cortico-hippocampal loop.

abstract：:The prefrontal cortex (PFC) and anterior cingulate cortex (ACC) have both been implicated in cognitive control, but their relative roles remain unclear. Here we recorded the activity of single neurons in both areas while monkeys performed a task that required them to switch between trials in which they had to look tow...

journal_title：Neuron

authors： Johnston K,Levin HM,Koval MJ,Everling S

更新日期：2007-02-01 00:00:00

abstract：:The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K...

journal_title：Neuron

authors： Jiang Y,Pico A,Cadene M,Chait BT,MacKinnon R

更新日期：2001-03-01 00:00:00

abstract：:The release of neurotransmitter-filled vesicles after action potentials occurs with discrete time courses: submillisecond phasic release that can be desynchronized by activity followed by "delayed release" that persists for tens of milliseconds. Delayed release has a well-established role in synaptic integration, but ...

journal_title：Neuron

authors： Rudolph S,Overstreet-Wadiche L,Wadiche JI

更新日期：2011-06-09 00:00:00

abstract：:Currently there is no general approach for achieving specific optogenetic control of genetically defined cell types in rats, which provide a powerful experimental system for numerous established neurophysiological and behavioral paradigms. To overcome this challenge we have generated genetically restricted recombinase...

journal_title：Neuron

authors： Witten IB,Steinberg EE,Lee SY,Davidson TJ,Zalocusky KA,Brodsky M,Yizhar O,Cho SL,Gong S,Ramakrishnan C,Stuber GD,Tye KM,Janak PH,Deisseroth K

更新日期：2011-12-08 00:00:00

abstract：:The long-term depression (LTD) of parallel fiber (PF) synapses onto Purkinje cells plays a central role in motor learning. Endocannabinoid release and LTD induction both depend upon activation of the metabotropic glutamate receptor mGluR1, require postsynaptic calcium increases, are synapse specific, and have a simila...

journal_title：Neuron

authors： Safo PK,Regehr WG

更新日期：2005-11-23 00:00:00

abstract：:In this issue of Neuron, Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3' UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors. ...

journal_title：Neuron

authors： Panayotis N,Fainzilber M

更新日期：2019-05-08 00:00:00

abstract：:Leukemia inhibitory factor (LIF) is a cytokine that affects the survival and differentiation of certain neuronal populations in vitro. To identify LIF-responsive neurons in the adult rat, we have demonstrated retrograde axonal transport of 125I-LIF to sensory and motor neurons. The accumulation of 125I-LIF by both cel...

journal_title：Neuron

authors： Curtis R,Scherer SS,Somogyi R,Adryan KM,Ip NY,Zhu Y,Lindsay RM,DiStefano PS

更新日期：1994-01-01 00:00:00

abstract：:Despite the fact that strong trial-to-trial correlated variability in responses has been reported in many cortical areas, recent evidence suggests that neuronal correlations are much lower than previously thought. Here, we used multicontact laminar probes to revisit the issue of correlated variability in primary visua...

journal_title：Neuron

authors： Hansen BJ,Chelaru MI,Dragoi V

更新日期：2012-11-08 00:00:00

abstract：:Fear is a graded central motive state ranging from mild to intense. As threat intensity increases, fear transitions from discriminative to generalized. The circuit mechanisms that process threats of different intensity are not well resolved. Here, we isolate a unique population of locally projecting neurons in the cen...

journal_title：Neuron

authors： Sanford CA,Soden ME,Baird MA,Miller SM,Schulkin J,Palmiter RD,Clark M,Zweifel LS

更新日期：2017-01-04 00:00:00

abstract：:Brain circuits endow behavioral flexibility. Here, we study circuits encoding flexible chemotaxis in C. elegans, where the animal navigates up or down NaCl gradients (positive or negative chemotaxis) to reach the salt concentration of previous growth (the set point). The ASER sensory neuron mediates positive and negat...

journal_title：Neuron

authors： Luo L,Wen Q,Ren J,Hendricks M,Gershow M,Qin Y,Greenwood J,Soucy ER,Klein M,Smith-Parker HK,Calvo AC,Colón-Ramos DA,Samuel AD,Zhang Y

更新日期：2014-06-04 00:00:00

abstract：:The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV cargo occurs at the plasma membrane. Activity-dependent bulk endocytosis (ADBE) ...

journal_title：Neuron

authors： Nicholson-Fish JC,Kokotos AC,Gillingwater TH,Smillie KJ,Cousin MA

更新日期：2015-12-02 00:00:00

abstract：:To examine the distribution of synaptic vesicle antigens during development of the cerebral cortex, antibodies against synapsin I and p65 were used on sections of cat cerebral cortex between E40 and adulthood. In the adult, the layers of the cerebral cortex are immunoreactive for each of these antigens, while the whit...

journal_title：Neuron

authors： Chun JJ,Shatz CJ

更新日期：1988-06-01 00:00:00

abstract：:Dopamine (DA) transmission mediates numerous aspects of behavior. Although DA release is strongly linked to firing of DA neurons, recent developments indicate the importance of presynaptic modulation at striatal dopaminergic terminals. The endocannabinoid (eCB) system regulates DA release and is a canonical gatekeeper...

journal_title：Neuron

authors： Mateo Y,Johnson KA,Covey DP,Atwood BK,Wang HL,Zhang S,Gildish I,Cachope R,Bellocchio L,Guzmán M,Morales M,Cheer JF,Lovinger DM

更新日期：2017-12-06 00:00:00

abstract：:The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is regulated during embryonic neural progenitor proliferation and neuronal migration through an inte...

journal_title：Neuron

authors： Singh KK,Ge X,Mao Y,Drane L,Meletis K,Samuels BA,Tsai LH

更新日期：2010-07-15 00:00:00

abstract：:In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...

journal_title：Neuron

authors： Grossmann T,Oberecker R,Koch SP,Friederici AD

更新日期：2010-03-25 00:00:00

abstract：:Synaptic activity induces changes in the number of dendritic spines. Here, we report a pathway of regulated endocytosis triggered by arcadlin, a protocadherin induced by electroconvulsive and other excitatory stimuli in hippocampal neurons. The homophilic binding of extracellular arcadlin domains activates TAO2beta, a...

journal_title：Neuron

authors： Yasuda S,Tanaka H,Sugiura H,Okamura K,Sakaguchi T,Tran U,Takemiya T,Mizoguchi A,Yagita Y,Sakurai T,De Robertis EM,Yamagata K

更新日期：2007-11-08 00:00:00

abstract：:Local axon degeneration is a common pathological feature of many neurodegenerative diseases and peripheral neuropathies. While it is believed to operate with an apoptosis-independent molecular program, the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons,...

journal_title：Neuron

authors： Zhai Q,Wang J,Kim A,Liu Q,Watts R,Hoopfer E,Mitchison T,Luo L,He Z

更新日期：2003-07-17 00:00:00

abstract：:To discover new genes involved in axon navigation, we conducted a forward genetic screen for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU. In Magellan mutant embryos, motor axons were error prone and wandered inefficiently at choice points within embryos, but paradoxic...

journal_title：Neuron

authors： Lewcock JW,Genoud N,Lettieri K,Pfaff SL

更新日期：2007-11-21 00:00:00

abstract：:Convergent evidence suggests that corticostriatal interactions act as a gate to select the input to working memory (WM). However, not all information in WM is relevant for behavior simultaneously. For this reason, a second "output gate" might advantageously govern which contents of WM influence behavior. Here, we test...

journal_title：Neuron

authors： Chatham CH,Frank MJ,Badre D

更新日期：2014-02-19 00:00:00

abstract：:Selective synaptic and axonal degeneration are critical aspects of both brain development and neurodegenerative disease. Inhibition of caspase signaling in neurons is a potential therapeutic strategy for neurodegenerative disease, but no neuron-specific modulators of caspase signaling have been described. Using a mass...

journal_title：Neuron

authors： Hertz NT,Adams EL,Weber RA,Shen RJ,O'Rourke MK,Simon DJ,Zebroski H,Olsen O,Morgan CW,Mileur TR,Hitchcock AM,Sinnott Armstrong NA,Wainberg M,Bassik MC,Molina H,Wells JA,Tessier-Lavigne M

更新日期：2019-08-07 00:00:00

abstract：:Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiolog...

journal_title：Neuron

authors： Yoon KJ,Ming GL,Song H

更新日期：2018-07-25 00:00:00

abstract：:Embryonic mouse neural tubes produce a variety of terminally differentiated cells in vitro, mostly neurons and glia. We report here that some of these cells differentiate into skeletal muscle cells. The possibility of mesoderm contamination was ruled out as follows. First, Dil+ muscle cells were present in cultures fr...

journal_title：Neuron

authors： Tajbakhsh S,Vivarelli E,Cusella-De Angelis G,Rocancourt D,Buckingham M,Cossu G

更新日期：1994-10-01 00:00:00

abstract：:Cortical development depends on the active integration of cell-autonomous and extrinsic cues, but the coordination of these processes is poorly understood. Here, we show that the apical complex protein Pals1 and Pten have opposing roles in localizing the Igf1R to the apical, ventricular domain of cerebral cortical pro...

journal_title：Neuron

authors： Lehtinen MK,Zappaterra MW,Chen X,Yang YJ,Hill AD,Lun M,Maynard T,Gonzalez D,Kim S,Ye P,D'Ercole AJ,Wong ET,LaMantia AS,Walsh CA

更新日期：2011-03-10 00:00:00

abstract：:Although numerous theoretical models implicate the prefrontal cortex (PFC) as a source of top-down control signals, empirical support is limited. In this review, we highlight direct evidence for this view of PFC function and discuss several lines of other supportive findings. Most evidence to-date is only suggestive d...

journal_title：Neuron

authors： Miller BT,D'Esposito M

更新日期：2005-11-23 00:00:00

abstract：:Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ ...

journal_title：Neuron

authors： Alcamo EA,Chirivella L,Dautzenberg M,Dobreva G,Fariñas I,Grosschedl R,McConnell SK

更新日期：2008-02-07 00:00:00

abstract：:Based on extrapolation from excitatory synapses, it is often assumed that depletion of the releasable pool of synaptic vesicles is the main factor underlying depression at inhibitory synapses. In this issue of Neuron, using subcellular patch-clamp recording from inhibitory presynaptic terminals, Kawaguchi and Sakaba (...

journal_title：Neuron

authors： Vandael DH,Espinoza C,Jonas P

更新日期：2015-03-18 00:00:00

abstract：:Critical periods are developmental time windows during which neuronal connections are shaped by experience. In this issue of Neuron, Davis et al. (2015) show that transplantation of embryonic inhibitory interneurons can reactivate critical period plasticity and reverse amblyopia in the visual cortex of adult mice. ...

journal_title：Neuron

authors： Levine JN,Gu Y,Cang J

更新日期：2015-05-20 00:00:00

abstract：:Synapses are lost during developmental synapse elimination. Until now, it has been impossible to follow elimination in the entirety of any neuron's branches and synapses. Using transgenic mice in which one or two of a muscle's motoneurons express variants of GFP, Keller-Peck et al. show in this issue of Neuron that el...

journal_title：Neuron

authors： Thompson WJ

更新日期：2001-08-16 00:00:00

abstract：:Binding between DIP and Dpr neuronal recognition proteins has been proposed to regulate synaptic connections between lamina and medulla neurons in the Drosophila visual system. Each lamina neuron was previously shown to express many Dprs. Here, we demonstrate, by contrast, that their synaptic partners typically expres...

journal_title：Neuron

authors： Cosmanescu F,Katsamba PS,Sergeeva AP,Ahlsen G,Patel SD,Brewer JJ,Tan L,Xu S,Xiao Q,Nagarkar-Jaiswal S,Nern A,Bellen HJ,Zipursky SL,Honig B,Shapiro L

更新日期：2018-12-19 00:00:00

abstract：:Action potentials initiate in the axon initial segment (AIS), a specialized compartment enriched with Na(+) and K(+) channels. Recently, we found that T- and R-type Ca(2+) channels are concentrated in the AIS, where they contribute to local subthreshold membrane depolarization and thereby influence action potential in...

journal_title：Neuron

authors： Bender KJ,Ford CP,Trussell LO

更新日期：2010-11-04 00:00:00