Abstract：
:Convergent evidence suggests that corticostriatal interactions act as a gate to select the input to working memory (WM). However, not all information in WM is relevant for behavior simultaneously. For this reason, a second "output gate" might advantageously govern which contents of WM influence behavior. Here, we test whether frontostriatal circuits previously implicated in input gating also support output gating during selection from WM. fMRI of a hierarchical rule task with dissociable input and output gating demands demonstrated greater lateral prefrontal cortex (PFC) recruitment and frontostriatal connectivity during output gating. Moreover, PFC and striatum correlated with distinct behavioral profiles. Whereas PFC recruitment correlated with mean efficiency of selection from WM, striatal recruitment and frontostriatal interactions correlated with its reliability, as though such dynamics stochastically gate WM's output. These results support the output gating hypothesis, suggesting that contextual representations in PFC influence striatum to select which information in WM drives responding.
journal_name
Neuronjournal_title
Neuronauthors
Chatham CH,Frank MJ,Badre Ddoi
10.1016/j.neuron.2014.01.002subject
Has Abstractpub_date
2014-02-19 00:00:00pages
930-42issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(14)00006-3journal_volume
81pub_type
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