Abstract：
:Ventral midbrain dopamine (DA) is unambiguously involved in motivation and behavioral arousal, yet the contributions of other DA populations to these processes are poorly understood. Here, we demonstrate that the dorsal raphe nucleus DA neurons are critical modulators of behavioral arousal and sleep-wake patterning. Using simultaneous fiber photometry and polysomnography, we observed time-delineated dorsal raphe nucleus dopaminergic (DRNDA) activity upon exposure to arousal-evoking salient cues, irrespective of their hedonic valence. We also observed broader fluctuations of DRNDA activity across sleep-wake cycles with highest activity during wakefulness. Both endogenous DRNDA activity and optogenetically driven DRNDA activity were associated with waking from sleep, with DA signal strength predictive of wake duration. Conversely, chemogenetic inhibition opposed wakefulness and promoted NREM sleep, even in the face of salient stimuli. Therefore, the DRNDA population is a critical contributor to wake-promoting pathways and is capable of modulating sleep-wake states according to the outside environment, wherein the perception of salient stimuli prompts vigilance and arousal.
journal_name
Neuronjournal_title
Neuronauthors
Cho JR,Treweek JB,Robinson JE,Xiao C,Bremner LR,Greenbaum A,Gradinaru Vdoi
10.1016/j.neuron.2017.05.020subject
Has Abstractpub_date
2017-06-21 00:00:00pages
1205-1219.e8issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30458-0journal_volume
94pub_type
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