Abstract:
:The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading "activation memories" between inhibitory synapses. Glutamatergic activity limits this inter-synaptic diffusion by trapping GABAARs at excitatory synapses. This novel form of activity-dependent hetero-synaptic interplay is likely to modulate dendritic synaptic signaling.
journal_name
Neuronjournal_title
Neuronauthors
de Luca E,Ravasenga T,Petrini EM,Polenghi A,Nieus T,Guazzi S,Barberis Adoi
10.1016/j.neuron.2017.06.022subject
Has Abstractpub_date
2017-07-05 00:00:00pages
63-69.e5issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30546-9journal_volume
95pub_type
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