Somatotopic representation of action words in human motor and premotor cortex.

Abstract:

:Since the early days of research into language and the brain, word meaning was assumed to be processed in specific brain regions, which most modern neuroscientists localize to the left temporal lobe. Here we use event-related fMRI to show that action words referring to face, arm, or leg actions (e.g., to lick, pick, or kick), when presented in a passive reading task, differentially activated areas along the motor strip that either were directly adjacent to or overlapped with areas activated by actual movement of the tongue, fingers, or feet. These results demonstrate that the referential meaning of action words has a correlate in the somatotopic activation of motor and premotor cortex. This rules out a unified "meaning center" in the human brain and supports a dynamic view according to which words are processed by distributed neuronal assemblies with cortical topographies that reflect word semantics.

journal_name

Neuron

journal_title

Neuron

authors

Hauk O,Johnsrude I,Pulvermüller F

doi

10.1016/s0896-6273(03)00838-9

subject

Has Abstract

pub_date

2004-01-22 00:00:00

pages

301-7

issue

2

eissn

0896-6273

issn

1097-4199

pii

S0896627303008389

journal_volume

41

pub_type

临床试验,杂志文章

相关文献

NEURON文献大全
  • Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting.

    abstract::Both acute and chronic changes in AMPA receptor (AMPAR) localization are critical for synaptic formation, maturation, and plasticity. Here I report that AMPARs are differentially sorted between recycling and degradative pathways following endocytosis. AMPAR sorting occurs in early endosomes and is regulated by synapti...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)00129-x

    authors: Ehlers MD

    更新日期:2000-11-01 00:00:00

  • The Jak/STAT pathway is involved in synaptic plasticity.

    abstract::The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcriptio...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.11.024

    authors: Nicolas CS,Peineau S,Amici M,Csaba Z,Fafouri A,Javalet C,Collett VJ,Hildebrandt L,Seaton G,Choi SL,Sim SE,Bradley C,Lee K,Zhuo M,Kaang BK,Gressens P,Dournaud P,Fitzjohn SM,Bortolotto ZA,Cho K,Collingridge GL

    更新日期:2012-01-26 00:00:00

  • Engrailed controls glial/neuronal cell fate decisions at the midline of the central nervous system.

    abstract::The molecular mechanisms involved in glial/neuronal fate decisions during embryonic development are largely unknown. Here we show that the segment-polarity gene engrailed, which encodes a homeodomain protein, controls these decisions within an insect CNS lineage. The grasshopper median neuroblast (MNB) generates both ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(94)90024-8

    authors: Condron BG,Patel NH,Zinn K

    更新日期:1994-09-01 00:00:00

  • Epitranscriptomes in the Adult Mammalian Brain: Dynamic Changes Regulate Behavior.

    abstract::Epitranscriptomic modification of mRNA affects its metabolism and has recently been shown to regulate brain development. Two studies in this issue of Neuron, Koranda et al. (2018) and Engel et al. (2018), uncover dynamic and critical roles of m6A/m RNA modifications in the adult mammalian brain in regulating physiolog...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2018.07.019

    authors: Yoon KJ,Ming GL,Song H

    更新日期:2018-07-25 00:00:00

  • Development of sensory neurons in the absence of NGF/TrkA signaling in vivo.

    abstract::The neurotrophin survival dependence of peripheral neurons in vitro is regulated by the proapoptotic BCL-2 homolog BAX. To study peripheral neuron development in the absence of neurotrophin signaling, we have generated mice that are double null for BAX and nerve growth factor (NGF), and BAX and the NGF receptor TrkA. ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80899-5

    authors: Patel TD,Jackman A,Rice FL,Kucera J,Snider WD

    更新日期:2000-02-01 00:00:00

  • L-myc and N-myc influence lineage determination in the central nervous system.

    abstract::The N-myc and the L-myc proto-oncogenes are expressed during embryonal development mainly in the developing brain. Studies of their expression in single neuroepithelial cells revealed that neural precursors not yet committed to the glial or the neuronal lineage expressed both genes, but after lineage commitment they e...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(92)90079-s

    authors: Bernard O,Drago J,Sheng H

    更新日期:1992-12-01 00:00:00

  • Development of a MR-visible compound for tracing neuroanatomical connections in vivo.

    abstract::Traditional studies of neuroanatomical connections require injection of tracer compounds into living brains, then histology of the postmortem tissue. Here, we describe and validate a compound that reveals neuronal connections in vivo, using MRI. The classic anatomical tracer CTB (cholera-toxin subunit-B) was conjugate...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2011.03.010

    authors: Wu CW,Vasalatiy O,Liu N,Wu H,Cheal S,Chen DY,Koretsky AP,Griffiths GL,Tootell RB,Ungerleider LG

    更新日期:2011-04-28 00:00:00

  • A Central Move for CB2 Receptors.

    abstract::The function of the CB2 cannabinoid receptor in the brain has long been a matter of debate. In this issue of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a cell-intrinsic hyperpolarization that controls self activity. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.neuron.2016.05.012

    authors: Quraishi SA,Paladini CA

    更新日期:2016-05-18 00:00:00

  • Hippocampal CA2 activity patterns change over time to a larger extent than between spatial contexts.

    abstract::The hippocampal CA2 subregion has a different anatomical connectivity pattern within the entorhino-hippocampal circuit than either the CA1 or CA3 subregion. Yet major differences in the neuronal activity patterns of CA2 compared with the other CA subregions have not been reported. We show that standard spatial and tem...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2014.12.001

    authors: Mankin EA,Diehl GW,Sparks FT,Leutgeb S,Leutgeb JK

    更新日期:2015-01-07 00:00:00

  • LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.

    abstract::LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using genetic and biochemical studies involving Lrrk loss-of-function mutants and Parkinson-related LRRK2(G2019S) gain-of-kinase function, we sh...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.08.022

    authors: Matta S,Van Kolen K,da Cunha R,van den Bogaart G,Mandemakers W,Miskiewicz K,De Bock PJ,Morais VA,Vilain S,Haddad D,Delbroek L,Swerts J,Chávez-Gutiérrez L,Esposito G,Daneels G,Karran E,Holt M,Gevaert K,Moechars DW,De

    更新日期:2012-09-20 00:00:00

  • Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.

    abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) has been described as a biochemical switch that is turned on by increases in intracellular calcium to mediate synaptic plasticity. Here, we show that reductions in CaMKII activity trigger persistent increases in intrinsic excitability. In spontaneously firing ves...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.04.009

    authors: Nelson AB,Gittis AH,du Lac S

    更新日期:2005-05-19 00:00:00

  • Switching gears: translational mastery of transcription during memory formation.

    abstract::A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a key regulatory event in the "neural decision" to undergo these p...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2007.04.003

    authors: Hoeffer CA,Klann E

    更新日期:2007-04-19 00:00:00

  • The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations.

    abstract::Nematode degenerins have been implicated in touch sensitivity and other forms of mechanosensation. Certain mutations in several degenerin genes cause the swelling, vacuolation, and death of neurons, and other mutations in the muscle degenerin gene unc-105 cause hypercontraction. Here, we confirm that unc-105 encodes a...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80503-6

    authors: García-Añoveros J,García JA,Liu JD,Corey DP

    更新日期:1998-06-01 00:00:00

  • Is NMDA receptor-coincidence detection required for learning and memory?

    abstract::The Mg2+ block of NMDA-type glutamate receptors (NMDARs) is crucial to their function as synaptic coincidence detectors. An analysis of Drosophila expressing a Mg2+-independent NMDAR by in this issue of Neuron concludes that the Mg2+ block is required primarily for long-term memory. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2012.05.008

    authors: Tabone CJ,Ramaswami M

    更新日期:2012-06-07 00:00:00

  • Biallelic Mutations in MYORG Cause Autosomal Recessive Primary Familial Brain Calcification.

    abstract::Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder characterized by bilateral calcifications in the basal ganglia and other brain regions. The genetic basis of this disorder remains unknown in a significant portion of familial cases. Here, we reported a recessive causal gene, MYORG, fo...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2018.05.037

    authors: Yao XP,Cheng X,Wang C,Zhao M,Guo XX,Su HZ,Lai LL,Zou XH,Chen XJ,Zhao Y,Dong EL,Lu YQ,Wu S,Li X,Fan G,Yu H,Xu J,Wang N,Xiong ZQ,Chen WJ

    更新日期:2018-06-27 00:00:00

  • An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales.

    abstract::Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2018.03.003

    authors: Octeau JC,Chai H,Jiang R,Bonanno SL,Martin KC,Khakh BS

    更新日期:2018-04-04 00:00:00

  • Re-exploring Mechanisms of Exploration.

    abstract::Deciding when to exploit what is already known and when to explore new possibilities is crucial for adapting to novel and dynamic environments. Using reinforcement-based decision making, Costa et al. (2019) in this issue of Neuron find that neurons in the amygdala and ventral-striatum differentially signal the benefit...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2019.07.021

    authors: Reitich-Stolero T,Aberg KC,Paz R

    更新日期:2019-08-07 00:00:00

  • New roles for ubiquitin in the assembly and function of neuronal circuits.

    abstract::A series of recent papers highlight a prominent role for ubiquitin in the formation and function of neural circuits. These new results focus attention on the molecular remodeling that occurs at various decision points in the life of growth cones and synapses. ...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/s0896-6273(02)00943-1

    authors: Murphey RK,Godenschwege TA

    更新日期:2002-09-26 00:00:00

  • Dynamic processes shape spatiotemporal properties of retinal waves.

    abstract::In the developing mammalian retina, spontaneous waves of action potentials are present in the ganglion cell layer weeks before vision. These waves are known to be generated by a synaptically connected network of amacrine cells and retinal ganglion cells, and exhibit complex spatiotemporal patterns, characterized by sh...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80940-x

    authors: Feller MB,Butts DA,Aaron HL,Rokhsar DS,Shatz CJ

    更新日期:1997-08-01 00:00:00

  • Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.

    abstract::The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence or mutations leads to the Fragile X syndrome (FXS). The β-amyloid precursor protein (APP) is involved in Alzheimer's disease, plays a role in synapse formation, and is upregulated in intellectual disabilities. Here, we s...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2015.06.032

    authors: Pasciuto E,Ahmed T,Wahle T,Gardoni F,D'Andrea L,Pacini L,Jacquemont S,Tassone F,Balschun D,Dotti CG,Callaerts-Vegh Z,D'Hooge R,Müller UC,Di Luca M,De Strooper B,Bagni C

    更新日期:2015-07-15 00:00:00

  • The cellular function of MASH1 in autonomic neurogenesis.

    abstract::Using primary cultures and immortalized multipotential stem cell lines derived from wild-type and Mash1 mutant neural crest cells, we have analyzed the cellular function of MASH1 in autonomic neurogenesis. We present evidence for the existence of a precursor expressing MASH1 and neuronal markers such as neurofilament,...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(95)90005-5

    authors: Sommer L,Shah N,Rao M,Anderson DJ

    更新日期:1995-12-01 00:00:00

  • Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.

    abstract::The N-terminal 17 amino acids of huntingtin (NT17) can be phosphorylated on serines 13 and 16; however, the significance of these modifications in Huntington's disease pathogenesis remains unknown. In this study, we developed BAC transgenic mice expressing full-length mutant huntingtin (fl-mhtt) with serines 13 and 16...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2009.11.020

    authors: Gu X,Greiner ER,Mishra R,Kodali R,Osmand A,Finkbeiner S,Steffan JS,Thompson LM,Wetzel R,Yang XW

    更新日期:2009-12-24 00:00:00

  • Distinct representations of cognitive and motivational signals in midbrain dopamine neurons.

    abstract::Dopamine is essential to cognitive functions. However, despite abundant studies demonstrating that dopamine neuron activity is related to reinforcement and motivation, little is known about what signals dopamine neurons convey to promote cognitive processing. We therefore examined dopamine neuron activity in monkeys p...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2013.07.002

    authors: Matsumoto M,Takada M

    更新日期:2013-09-04 00:00:00

  • Seeing is believing: GFP transgenics illuminate synapse elimination.

    abstract::Synapses are lost during developmental synapse elimination. Until now, it has been impossible to follow elimination in the entirety of any neuron's branches and synapses. Using transgenic mice in which one or two of a muscle's motoneurons express variants of GFP, Keller-Peck et al. show in this issue of Neuron that el...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/s0896-6273(01)00380-4

    authors: Thompson WJ

    更新日期:2001-08-16 00:00:00

  • Adaptive Prediction Error Coding in the Human Midbrain and Striatum Facilitates Behavioral Adaptation and Learning Efficiency.

    abstract::Effective error-driven learning benefits from scaling of prediction errors to reward variability. Such behavioral adaptation may be facilitated by neurons coding prediction errors relative to the standard deviation (SD) of reward distributions. To investigate this hypothesis, we required participants to predict the ma...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.04.019

    authors: Diederen KM,Spencer T,Vestergaard MD,Fletcher PC,Schultz W

    更新日期:2016-06-01 00:00:00

  • Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

    abstract::A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the song control circuit is altered during this critical period. The RNA encodes a soluble presynaptic protein that forms a predic...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(95)90040-3

    authors: George JM,Jin H,Woods WS,Clayton DF

    更新日期:1995-08-01 00:00:00

  • Working Memory Enhances Cortical Representations via Spatially Specific Coordination of Spike Times.

    abstract::The online maintenance and manipulation of information in working memory (WM) is essential for guiding behavior based on our goals. Understanding how WM alters sensory processing in pursuit of different behavioral objectives is therefore crucial to establish the neural basis of our goal-directed behavior. Here we show...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2018.01.012

    authors: Bahmani Z,Daliri MR,Merrikhi Y,Clark K,Noudoost B

    更新日期:2018-02-21 00:00:00

  • Sequences of autophosphorylation sites in neuronal type II CaM kinase that control Ca2(+)-independent activity.

    abstract::After initial activation by Ca2+, the catalytic activity of type II Ca2+/calmodulin-dependent protein kinase rapidly becomes partially independent of Ca2+. The transition is caused by autophosphorylation of a few subunits in the dodecameric holoenzyme, which is composed of varying proportions of two homologous types o...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(88)90109-2

    authors: Miller SG,Patton BL,Kennedy MB

    更新日期:1988-09-01 00:00:00

  • Effects of long-term visual experience on responses of distinct classes of single units in inferior temporal cortex.

    abstract::Primates can learn to recognize a virtually limitless number of visual objects. A candidate neural substrate for this adult plasticity is the inferior temporal cortex (ITC). Using a large stimulus set, we explored the impact that long-term experience has on the response properties of two classes of neurons in ITC: bro...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.01.032

    authors: Woloszyn L,Sheinberg DL

    更新日期:2012-04-12 00:00:00

  • Kv1.1 channels act as mechanical brake in the senses of touch and pain.

    abstract::Molecular determinants of threshold sensitivity of mammalian mechanoreceptors are unknown. Here, we identify a mechanosensitive (MS) K(+) current (IKmech) that governs mechanical threshold and adaptation of distinct populations of mechanoreceptors. Toxin profiling and transgenic mouse studies indicate that IKmech is c...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.12.035

    authors: Hao J,Padilla F,Dandonneau M,Lavebratt C,Lesage F,Noël J,Delmas P

    更新日期:2013-03-06 00:00:00