Abstract:
:The N-myc and the L-myc proto-oncogenes are expressed during embryonal development mainly in the developing brain. Studies of their expression in single neuroepithelial cells revealed that neural precursors not yet committed to the glial or the neuronal lineage expressed both genes, but after lineage commitment they expressed either N-myc or L-myc. Moreover, enforced expression of L-myc in the neural precursor cell line 2.3D caused neuronal differentiation, while the expression of N-myc promoted glial differentiation. These results indicate that L-myc and N-myc play critical roles in lineage determination for the central nervous system.
journal_name
Neuronjournal_title
Neuronauthors
Bernard O,Drago J,Sheng Hdoi
10.1016/0896-6273(92)90079-ssubject
Has Abstractpub_date
1992-12-01 00:00:00pages
1217-24issue
6eissn
0896-6273issn
1097-4199pii
0896-6273(92)90079-Sjournal_volume
9pub_type
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