Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

abstract：:The functional expression of Ca2+-activated K+ channels (KCa) in developing chick ciliary ganglion (CG) neurons requires interactions with target tissues and preganglionic innervation. Here, we show that the stimulatory effects of target tissues are mediated by an isoform of TGFbeta. Exposure of cultured CG neurons to...

journal_title：Neuron

authors： Cameron JS,Lhuillier L,Subramony P,Dryer SE

更新日期：1998-11-01 00:00:00

abstract：:Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. We examined the effects of cadherin blockage on synaptogenesis in cultured hippocampal neurons. This blockade resulted in alterations of dendritic spin...

journal_title：Neuron

authors： Togashi H,Abe K,Mizoguchi A,Takaoka K,Chisaka O,Takeichi M

更新日期：2002-07-03 00:00:00

abstract：:It has been hypothesized that the direction of synaptic weight change elicited by synaptic activity depends on the magnitude of the activity-dependent rise in intracellular Ca2+ concentration. Several aspects of this hypothesis were examined at the Schaffer collateral CA1 synapse, where both long-term depression (LTD)...

journal_title：Neuron

authors： Cummings JA,Mulkey RM,Nicoll RA,Malenka RC

更新日期：1996-04-01 00:00:00

abstract：:Visual experience before eye-opening is not usually thought to have any developmental significance. Here we show that naturalistic visual stimuli presented through unopened eyelids robustly activate neurons in the ferret dorsal lateral geniculate nucleus. Further, dark-rearing prior to natural eye-opening has striking...

journal_title：Neuron

authors： Akerman CJ,Smyth D,Thompson ID

更新日期：2002-12-05 00:00:00

abstract：:The N-terminal 17 amino acids of huntingtin (NT17) can be phosphorylated on serines 13 and 16; however, the significance of these modifications in Huntington's disease pathogenesis remains unknown. In this study, we developed BAC transgenic mice expressing full-length mutant huntingtin (fl-mhtt) with serines 13 and 16...

journal_title：Neuron

authors： Gu X,Greiner ER,Mishra R,Kodali R,Osmand A,Finkbeiner S,Steffan JS,Thompson LM,Wetzel R,Yang XW

更新日期：2009-12-24 00:00:00

abstract：:The Neurodata Without Borders (NWB) initiative promotes data standardization in neuroscience to increase research reproducibility and opportunities. In the first NWB pilot project, neurophysiologists and software developers produced a common data format for recordings and metadata of cellular electrophysiology and opt...

journal_title：Neuron

authors： Teeters JL,Godfrey K,Young R,Dang C,Friedsam C,Wark B,Asari H,Peron S,Li N,Peyrache A,Denisov G,Siegle JH,Olsen SR,Martin C,Chun M,Tripathy S,Blanche TJ,Harris K,Buzsáki G,Koch C,Meister M,Svoboda K,Sommer FT

更新日期：2015-11-18 00:00:00

abstract：:The modulation of high voltage-activated (HVA) Ca2+ currents by L-glutamate and its agonists was investigated in cultured rat hypothalamic neurons. L-Glutamate and agonists selective for NMDA or non-NMDA receptors reversibly inhibited HVA Ca2+ currents. The putative presynaptic glutamate receptor agonist L-2-amino-4-p...

journal_title：Neuron

authors： Zeilhofer HU,Müller TH,Swandulla D

更新日期：1993-05-01 00:00:00

abstract：:The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3 ubiquitin ligases WW-Containing Proteins 1 and 2 (Wwp1 and Wwp2) are indispensable for proper polarization of developing neurons. We show that knockout of Wwp1 and...

journal_title：Neuron

authors： Ambrozkiewicz MC,Schwark M,Kishimoto-Suga M,Borisova E,Hori K,Salazar-Lázaro A,Rusanova A,Altas B,Piepkorn L,Bessa P,Schaub T,Zhang X,Rabe T,Ripamonti S,Rosário M,Akiyama H,Jahn O,Kobayashi T,Hoshino M,Tarabykin V,

更新日期：2018-12-05 00:00:00

abstract：:The p75 neurotrophin receptor (p75(NTR)) is involved in numerous neuronal signaling paths but its fundamental signaling mechanisms are unknown. In this issue of Neuron, Vilar et al. show that p75NTR functions as a covalently crosslinked dimer to transduce NGF-induced signaling events. ...

journal_title：Neuron

authors： Barker PA

更新日期：2009-04-16 00:00:00

abstract：:Expression of aversive memories is key for survival, but the underlying brain mechanisms are not fully understood. Medial habenular (MHb) axons corelease glutamate and acetylcholine onto target postsynaptic interpeduncular (IPN) neurons, but their role in aversive memories has not been addressed so far. We found that ...

journal_title：Neuron

authors： Soria-Gómez E,Busquets-Garcia A,Hu F,Mehidi A,Cannich A,Roux L,Louit I,Alonso L,Wiesner T,Georges F,Verrier D,Vincent P,Ferreira G,Luo M,Marsicano G

更新日期：2015-10-21 00:00:00

abstract：:While nerve growth factor (NGF) is best known for its trophic functions, recent experiments indicate that it can also cause cell death during development by activating the neurotrophin receptor p75. We now identify microglial cells as the source of NGF as a killing agent in the developing eye. When the retina is separ...

journal_title：Neuron

authors： Frade JM,Barde YA

更新日期：1998-01-01 00:00:00

abstract：:Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...

journal_title：Neuron

authors： Divakaruni SS,Van Dyke AM,Chandra R,LeGates TA,Contreras M,Dharmasri PA,Higgs HN,Lobo MK,Thompson SM,Blanpied TA

更新日期：2018-11-21 00:00:00

abstract：:Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder characterized by bilateral calcifications in the basal ganglia and other brain regions. The genetic basis of this disorder remains unknown in a significant portion of familial cases. Here, we reported a recessive causal gene, MYORG, fo...

journal_title：Neuron

authors： Yao XP,Cheng X,Wang C,Zhao M,Guo XX,Su HZ,Lai LL,Zou XH,Chen XJ,Zhao Y,Dong EL,Lu YQ,Wu S,Li X,Fan G,Yu H,Xu J,Wang N,Xiong ZQ,Chen WJ

更新日期：2018-06-27 00:00:00

abstract：:Protein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain elusive. We combined pharmacological manipulations of kinase and phosphatase activities with mutational studies on the exocytotic machinery driving fusion of catecholamine-containing vesicles from chromaffin cells. We found t...

journal_title：Neuron

authors： Nagy G,Reim K,Matti U,Brose N,Binz T,Rettig J,Neher E,Sørensen JB

更新日期：2004-02-05 00:00:00

abstract：:Induced CREB activity is a hallmark of long-term memory, but the full repertoire of CREB transcriptional targets required specifically for memory is not known in any system. To obtain a more complete picture of the mechanisms involved in memory, we combined memory training with genome-wide transcriptional analysis of ...

journal_title：Neuron

authors： Lakhina V,Arey RN,Kaletsky R,Kauffman A,Stein G,Keyes W,Xu D,Murphy CT

更新日期：2015-01-21 00:00:00

abstract：:Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expre...

journal_title：Neuron

authors： Bramblett DE,Pennesi ME,Wu SM,Tsai MJ

更新日期：2004-09-16 00:00:00

abstract：:Mutations in a synaptic organizing pathway contribute to autism. Autism-associated mutations in MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) are thought to reduce excitatory/inhibitory transmission. However, we show that mutation of Mdga2 elevates excitatory transmission, and that MDGA2 blocks n...

journal_title：Neuron

authors： Connor SA,Ammendrup-Johnsen I,Chan AW,Kishimoto Y,Murayama C,Kurihara N,Tada A,Ge Y,Lu H,Yan R,LeDue JM,Matsumoto H,Kiyonari H,Kirino Y,Matsuzaki F,Suzuki T,Murphy TH,Wang YT,Yamamoto T,Craig AM

更新日期：2016-09-07 00:00:00

abstract：:Olfactory receptor neurons (ORNs) are replaced and differentiate in adult animals, but differentiation in dissociated cell culture has not been demonstrated. To test whether contact with the CNS regulates maturation, neonatal rat olfactory cells were grown on a culture substrate or on CNS astrocytes. Mature ORNs, immu...

journal_title：Neuron

authors： Pixley SK

更新日期：1992-06-01 00:00:00

abstract：:Bcl-2 is a major regulator of programmed cell death, a critical process in shaping the developing nervous system. To assess whether Bcl-2 is involved in regulating neuronal survival and in mediating the neuroprotective action of neurotrophic factors, we generated Bcl-2-deficient mice. At birth, the number of facial mo...

journal_title：Neuron

authors： Michaelidis TM,Sendtner M,Cooper JD,Airaksinen MS,Holtmann B,Meyer M,Thoenen H

更新日期：1996-07-01 00:00:00

abstract：:Mammalian olfactory sensory neurons that express a particular odorant receptor (OR) project axons to the same few glomeruli in the olfactory bulb. In this issue of Neuron, Vassalli et al. use OR minigenes that coexpress histochemical markers and show that the determinants in the sensory neurons required to generate th...

journal_title：Neuron

authors： Ranganathan R,Buck LB

更新日期：2002-08-15 00:00:00

abstract：:The formation of topographic neural maps relies on the coordinate assignment of neuronal cell body position and axonal trajectory. The projection of motor neurons of the lateral motor column (LMC) along the dorsoventral axis of the limb mesenchyme constitutes a simple topographic map that is organized in a binary mann...

journal_title：Neuron

authors： Kania A,Jessell TM

更新日期：2003-05-22 00:00:00

abstract：:Careful functional dissection of mouse neuromuscular junctions (NMJs) formed in the absence of NCAM reveal that in spite of relatively normal morphology and ultrastructure, the presynaptic terminals have profound alterations in the mechanisms of recycling of synaptic vesicles. These alterations, including the appearan...

journal_title：Neuron

authors： Ryan TA

更新日期：2001-12-06 00:00:00

abstract：:The cerebellum is well appreciated to impart speed, smoothness, and precision to skilled movements such as reaching. How these functions are executed by the final output stage of the cerebellum, the cerebellar nuclei, remains unknown. Here, we identify a causal relationship between cerebellar output and mouse reach ki...

journal_title：Neuron

authors： Becker MI,Person AL

更新日期：2019-07-17 00:00:00

abstract：:The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked m...

journal_title：Neuron

authors： Xiong ZQ,McNamara JO

更新日期：2002-09-12 00:00:00

abstract：:Long-term, but not short-term, facilitation induced by 5-HT in Aplysia sensory neurons is blocked by application of inhibitors of protein synthesis or RNA synthesis during the 1.5 hr training period. These findings suggest that genes and proteins not needed for the short-term process are required for long-term facilit...

journal_title：Neuron

authors： Barzilai A,Kennedy TE,Sweatt JD,Kandel ER

更新日期：1989-06-01 00:00:00

abstract：:As different classes of sensory neurons project into the CNS, their axons segregate and establish distinct trajectories and target zones. One striking instance of axonal segregation is the projection of sensory neurons into the spinal cord, where proprioceptive axons avoid the superficial dorsal horn-the target zone o...

journal_title：Neuron

authors： Yoshida Y,Han B,Mendelsohn M,Jessell TM

更新日期：2006-12-07 00:00:00

abstract：:The selection and timing of actions are subject to determinate influences such as sensory cues and internal state as well as to effectively stochastic variability. Although stochastic choice mechanisms are assumed by many theoretical models, their origin and mechanisms remain poorly understood. Here we investigated th...

journal_title：Neuron

authors： Murakami M,Shteingart H,Loewenstein Y,Mainen ZF

更新日期：2017-05-17 00:00:00

abstract：:The dorsal anterior cingulate cortex (dACC) has a near-ubiquitous presence in the neuroscience of cognitive control. It has been implicated in a diversity of functions, from reward processing and performance monitoring to the execution of control and action selection. Here, we propose that this diversity can be unders...

journal_title：Neuron

authors： Shenhav A,Botvinick MM,Cohen JD

更新日期：2013-07-24 00:00:00

abstract：:Accumulation of specific proteins at synaptic structures is essential for synapse assembly and function, but mechanisms regulating local protein enrichment remain poorly understood. At the neuromuscular junction (NMJ), subsynaptic nuclei underlie motor axon terminals within extrafusal muscle fibers and are transcripti...

journal_title：Neuron

authors： Hippenmeyer S,Huber RM,Ladle DR,Murphy K,Arber S

更新日期：2007-09-06 00:00:00

abstract：:TRP and TRPL are two light-sensitive cation channel subunits required for the Drosophila photoresponse; however, our understanding of the identities, subunit composition, and function of the light-responsive channels is incomplete. To explain the residual photoresponse that remains in the trp mutant, a third TRP-relat...

journal_title：Neuron

authors： Xu XZ,Chien F,Butler A,Salkoff L,Montell C

更新日期：2000-06-01 00:00:00