Abstract:
:Uptake and transneuronal passage of wild-type and attenuated strains of a swine alpha-herpesvirus (pseudorabies [PRV]) were examined in rat visual projections. Both strains of virus infected subpopulations of retinal ganglion cells and passed transneuronally to infect retino-recipient neurons in the forebrain. However, the location of infected forebrain neurons varied with the strain of virus. Intravitreal injection of wild-type virus produced two temporally separated waves of infection that eventually reached all known retino-recipient regions of the central neuraxis. By contrast, the attenuated strain of PRV selectively infected a functionally distinct subset of retinal ganglion cells with restricted central projections. The data indicate that projection-specific groups of ganglion cells are differentially susceptible to the two strains of virus and suggest that this sensitivity may be receptor mediated.
journal_name
Neuronjournal_title
Neuronauthors
Card JP,Whealy ME,Robbins AK,Moore RY,Enquist LWdoi
10.1016/0896-6273(91)90236-ssubject
Has Abstractpub_date
1991-06-01 00:00:00pages
957-69issue
6eissn
0896-6273issn
1097-4199pii
0896-6273(91)90236-Sjournal_volume
6pub_type
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