Abstract:
:Axon bifurcation results in the formation of sister branches, and divergent segregation of the sister branches is essential for efficient innervation of multiple targets. From a genetic mosaic screen, we find that a lethal mutation in the Drosophila Down syndrome cell adhesion molecule (Dscam) specifically perturbs segregation of axonal branches in the mushroom bodies. Single axon analysis further reveals that Dscam mutant axons generate additional branches, which randomly segregate among the available targets. Moreover, when only one target remains, branching is suppressed in wild-type axons while Dscam mutant axons still form multiple branches at the original bifurcation point. Taken together, we conclude that Dscam controls axon branching and guidance such that a neuron can innervate multiple targets with minimal branching.
journal_name
Neuronjournal_title
Neuronauthors
Wang J,Zugates CT,Liang IH,Lee CH,Lee Tdoi
10.1016/s0896-6273(02)00570-6subject
Has Abstractpub_date
2002-02-14 00:00:00pages
559-71issue
4eissn
0896-6273issn
1097-4199pii
S0896627302005706journal_volume
33pub_type
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