Abstract:
:The location, size, and number of synapses critically influence the specificity and strength of neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are transported by molecular motors and accumulate at discrete presynaptic loci. Little is known about the mechanisms coordinating presynaptic protein transport and deposition to achieve proper distribution of synaptic material. Here we show that SV and AZ proteins exhibit extensive cotransport and undergo frequent pauses. At the axonal and synaptic pause sites, the balance between the capture and dissociation of mobile transport packets determines the extent of presynaptic assembly. The small G protein ARL-8 inhibits assembly by promoting dissociation, while a JNK kinase pathway and AZ assembly proteins inhibit dissociation. Furthermore, ARL-8 directly binds to the UNC-104/KIF1A motor to limit the capture efficiency. Together, molecular regulation of the dichotomy between axonal trafficking and local assembly controls vital aspects of synapse formation and maintenance.
journal_name
Neuronjournal_title
Neuronauthors
Wu YE,Huo L,Maeder CI,Feng W,Shen Kdoi
10.1016/j.neuron.2013.04.035subject
Has Abstractpub_date
2013-06-19 00:00:00pages
994-1011issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(13)00366-8journal_volume
78pub_type
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