Tau propagation, different tau phenotypes, and prion-like properties of tau.

Abstract:

:Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies.

journal_name

Neuron

journal_title

Neuron

authors

Hyman BT

doi

10.1016/j.neuron.2014.06.004

subject

Has Abstract

pub_date

2014-06-18 00:00:00

pages

1189-90

issue

6

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(14)00494-2

journal_volume

82

pub_type

评论,杂志文章

相关文献

NEURON文献大全
  • Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders.

    abstract::To characterize the role of rare complete human knockouts in autism spectrum disorders (ASDs), we identify genes with homozygous or compound heterozygous loss-of-function (LoF) variants (defined as nonsense and essential splice sites) from exome sequencing of 933 cases and 869 controls. We identify a 2-fold increase i...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.12.029

    authors: Lim ET,Raychaudhuri S,Sanders SJ,Stevens C,Sabo A,MacArthur DG,Neale BM,Kirby A,Ruderfer DM,Fromer M,Lek M,Liu L,Flannick J,Ripke S,Nagaswamy U,Muzny D,Reid JG,Hawes A,Newsham I,Wu Y,Lewis L,Dinh H,Gross S,W

    更新日期:2013-01-23 00:00:00

  • Experience-dependent development of spinal motor neurons.

    abstract::Locomotor activity in many species undergoes pronounced alterations in early postnatal life, and environmental cues may be responsible for modifying this process. To determine how these events are reflected in the nervous system, we studied rats reared under two different conditions-the presence or absence of gravity-...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)81164-2

    authors: Inglis FM,Zuckerman KE,Kalb RG

    更新日期:2000-05-01 00:00:00

  • Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.

    abstract::In neurons, posttranslational modification by palmitate regulates the trafficking and function of signaling molecules, neurotransmitter receptors, and associated synaptic scaffolding proteins. However, the enzymatic machinery involved in protein palmitoylation has remained elusive. Here, using biochemical assays, we s...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2004.11.027

    authors: Huang K,Yanai A,Kang R,Arstikaitis P,Singaraja RR,Metzler M,Mullard A,Haigh B,Gauthier-Campbell C,Gutekunst CA,Hayden MR,El-Husseini A

    更新日期:2004-12-16 00:00:00

  • Histidine residues regulate the transition of photoexcited rhodopsin to its active conformation, metarhodopsin II.

    abstract::The biologically active photoproduct of rhodopsin, metarhodopsin II (M II), exists in a pH-sensitive equilibrium with its precursor, metarhodopsin I (M I). Increasing acidity favors M II, with the midpoint of the pH titration curve at pH 6.4. To test the long-standing proposal that histidine protonation regulates this...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(92)90274-h

    authors: Weitz CJ,Nathans J

    更新日期:1992-03-01 00:00:00

  • The double helix takes the witness stand: behavioral and neuropsychiatric genetics in court.

    abstract::Data on neuropsychiatric and behavioral genetics have attracted legal interest, as attorneys explore their use in criminal and civil cases. These developments may assist judges and juries in making difficult judgments-but they bring substantial risk of misinterpretation and misuse. ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2014.05.026

    authors: Appelbaum PS

    更新日期:2014-06-04 00:00:00

  • Learning How Neurons Fail Inside of Networks: Nonhuman Primates Provide Critical Data for Psychiatry.

    abstract::Advancing psychiatry requires understanding brain malfunction at a microscopic scale, where neurons and synapses operate under constraints imposed by behavior, cognition, and neural architecture. Nonhuman primates are unmatched in approximating the structural and computational environment of the human brain. ...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2019.02.030

    authors: Heilbronner SR,Chafee MV

    更新日期:2019-04-03 00:00:00

  • A Circuit for Integration of Head- and Visual-Motion Signals in Layer 6 of Mouse Primary Visual Cortex.

    abstract::To interpret visual-motion events, the underlying computation must involve internal reference to the motion status of the observer's head. We show here that layer 6 (L6) principal neurons in mouse primary visual cortex (V1) receive a diffuse, vestibular-mediated synaptic input that signals the angular velocity of hori...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2018.02.023

    authors: Vélez-Fort M,Bracey EF,Keshavarzi S,Rousseau CV,Cossell L,Lenzi SC,Strom M,Margrie TW

    更新日期:2018-04-04 00:00:00

  • An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales.

    abstract::Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2018.03.003

    authors: Octeau JC,Chai H,Jiang R,Bonanno SL,Martin KC,Khakh BS

    更新日期:2018-04-04 00:00:00

  • ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation.

    abstract::The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.04.024

    authors: Pearson RA,Dale N,Llaudet E,Mobbs P

    更新日期:2005-06-02 00:00:00

  • Synaptic homeostasis on the fast track.

    abstract::Synaptic homeostasis is a phenomenon that prevents the nervous system from descending into chaos. In this issue of Neuron, Frank et al. overturn the notion that synaptic homeostasis at Drosophila NMJs is a slow developmental process. They report that postsynaptic changes are offset within minutes by a homeostatic incr...

    journal_title:Neuron

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.neuron.2006.11.006

    authors: Macleod GT,Zinsmaier KE

    更新日期:2006-11-22 00:00:00

  • Constitutively active mutants of rhodopsin.

    abstract::Two critical amino acids in the visual pigment rhodopsin are Lys-296, the site of attachment of retinal to the protein through a protonated Schiff base linkage, and Glu-113, the Schiff base counterion. Mutation of Lys-296 or Glu-113 results in constitutive activation of opsin, as assayed by its ability to activate tra...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(92)90034-b

    authors: Robinson PR,Cohen GB,Zhukovsky EA,Oprian DD

    更新日期:1992-10-01 00:00:00

  • TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C. elegans.

    abstract::Membrane excitability is a fundamentally important feature for all excitable cells including both neurons and muscle cells. However, the background depolarizing conductances in excitable cells, especially in muscle cells, are not well characterized. Although mutations in transmembrane channel-like (TMC) proteins TMC1 ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2017.12.041

    authors: Yue X,Zhao J,Li X,Fan Y,Duan D,Zhang X,Zou W,Sheng Y,Zhang T,Yang Q,Luo J,Duan S,Xiao R,Kang L

    更新日期:2018-02-07 00:00:00

  • Direct Medial Entorhinal Cortex Input to Hippocampal CA1 Is Crucial for Extended Quiet Awake Replay.

    abstract::Hippocampal replays have been demonstrated to play a crucial role in memory. Chains of ripples (ripple bursts) in CA1 have been reported to co-occur with long-range place cell sequence replays during the quiet awake state, but roles of neural inputs to CA1 in ripple bursts and replays are unknown. Here we show that ri...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2017.09.017

    authors: Yamamoto J,Tonegawa S

    更新日期:2017-09-27 00:00:00

  • Role of olivary electrical coupling in cerebellar motor learning.

    abstract::The level of electrotonic coupling in the inferior olive is extremely high, but its functional role in cerebellar motor control remains elusive. Here, we subjected mice that lack olivary coupling to paradigms that require learning-dependent timing. Cx36-deficient mice showed impaired timing of both locomotion and eye-...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.03.016

    authors: Van Der Giessen RS,Koekkoek SK,van Dorp S,De Gruijl JR,Cupido A,Khosrovani S,Dortland B,Wellershaus K,Degen J,Deuchars J,Fuchs EC,Monyer H,Willecke K,De Jeu MT,De Zeeuw CI

    更新日期:2008-05-22 00:00:00

  • Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.

    abstract:VIDEO ABSTRACT:The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.02.009

    authors: Harwell CC,Parker PR,Gee SM,Okada A,McConnell SK,Kreitzer AC,Kriegstein AR

    更新日期:2012-03-22 00:00:00

  • Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In Vivo.

    abstract::Nociceptive terminals possess the elements for detecting, transmitting, and modulating noxious signals, thus being pivotal for pain sensation. Despite this, a functional description of the transduction process by the terminals, in physiological conditions, has not been fully achieved. Here, we studied how nociceptive ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.03.005

    authors: Goldstein RH,Barkai O,Íñigo-Portugués A,Katz B,Lev S,Binshtok AM

    更新日期:2019-05-22 00:00:00

  • The transcription factor Bhlhb4 is required for rod bipolar cell maturation.

    abstract::Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expre...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2004.08.032

    authors: Bramblett DE,Pennesi ME,Wu SM,Tsai MJ

    更新日期:2004-09-16 00:00:00

  • Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD.

    abstract::Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGluR-dependent LTD. The increase in Arc/Arg3.1 translation requires e...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.05.023

    authors: Park S,Park JM,Kim S,Kim JA,Shepherd JD,Smith-Hicks CL,Chowdhury S,Kaufmann W,Kuhl D,Ryazanov AG,Huganir RL,Linden DJ,Worley PF

    更新日期:2008-07-10 00:00:00

  • Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line.

    abstract::We constructed a recombinant baculovirus, A. californica nuclear polyhedrosis virus, containing the Drosophila Shaker H4 K+ channel cDNA under control of the polyhedrin promoter. When infected with this recombinant baculovirus, the cell line Sf9, derived from the army-worm caterpillar S. frugiperda, expresses fully fu...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(90)90311-3

    authors: Klaiber K,Williams N,Roberts TM,Papazian DM,Jan LY,Miller C

    更新日期:1990-08-01 00:00:00

  • Timing-based LTP and LTD at vertical inputs to layer II/III pyramidal cells in rat barrel cortex.

    abstract::Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)00008-8

    authors: Feldman DE

    更新日期:2000-07-01 00:00:00

  • TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons.

    abstract::The vertebrate ventral midbrain contains 3-4 x 10(4) dopaminergic neurons that influence motor activity, emotional behavior, and cognition. Recently, glial cell line-derived neurotrophic factor (GDNF) was shown to be a potent survival factor for these dopaminergic neurons in culture. However, many midbrain dopaminergi...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(94)90062-0

    authors: Poulsen KT,Armanini MP,Klein RD,Hynes MA,Phillips HS,Rosenthal A

    更新日期:1994-11-01 00:00:00

  • Calcium and calcium-dependent chloride currents generate action potentials in solitary cone photoreceptors.

    abstract::Vertebrate rod and cone photoreceptors hyperpolarize when illuminated. However, synaptic input from horizontal cells can depolarize cones and even elicit action potentials. Using the whole-cell tight-seal recording technique, we determined that, in solitary cones isolated from a lizard retina, action potentials can be...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(88)90181-x

    authors: Maricq AV,Korenbrot JI

    更新日期:1988-08-01 00:00:00

  • Multiple calcium-dependent processes related to secretion in bovine chromaffin cells.

    abstract::We have used the caged calcium compound DM-nitrophen to investigate the kinetics of calcium-dependent secretion in bovine chromaffin cells. Perfusion with partially calcium-loaded nitrophen often caused a loading transient--slow secretion for up to 1 min due to displacement of Ca2+ by cytoplasmic Mg2+. Flash photolysi...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(93)90238-m

    authors: Neher E,Zucker RS

    更新日期:1993-01-01 00:00:00

  • Top-down coordination of local cortical state during selective attention.

    abstract::Spontaneous fluctuations in cortical excitability influence sensory processing and behavior. These fluctuations, long thought to reflect global changes in cortical state, were recently found to be modulated locally within a retinotopic map during spatially selective attention. We report that periods of vigorous (On) a...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2020.12.013

    authors: van Kempen J,Gieselmann MA,Boyd M,Steinmetz NA,Moore T,Engel TA,Thiele A

    更新日期:2020-12-30 00:00:00

  • Two novel GABAA receptor subunits exist in distinct neuronal subpopulations.

    abstract::Two cDNAs encoding novel GABAA receptor subunits were isolated from a rat brain library. These subunits, gamma 2 and delta, share approximately 35% sequence identity with alpha and beta subunits and form functional GABA-gated chloride channels when expressed alone in vitro. The gamma 2 subunit is the rat homolog of th...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(89)90257-2

    authors: Shivers BD,Killisch I,Sprengel R,Sontheimer H,Köhler M,Schofield PR,Seeburg PH

    更新日期:1989-09-01 00:00:00

  • A Mirror-Symmetric Excitatory Link Coordinates Odor Maps across Olfactory Bulbs and Enables Odor Perceptual Unity.

    abstract::Sensory input reaching the brain from bilateral and offset channels is nonetheless perceived as unified. This unity could be explained by simultaneous projections to both hemispheres, or inter-hemispheric information transfer between sensory cortical maps. Odor input, however, is not topographically organized, nor doe...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2018.07.012

    authors: Grobman M,Dalal T,Lavian H,Shmuel R,Belelovsky K,Xu F,Korngreen A,Haddad R

    更新日期:2018-08-22 00:00:00

  • The cloned capsaicin receptor integrates multiple pain-producing stimuli.

    abstract::Capsaicin, the main pungent ingredient in "hot" chili peppers, elicits buming pain by activating specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid receptor (VR1) is a cation channel that is also activated by noxious heat. Here, analysis of heat-evoked single channel currents in excised memb...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80564-4

    authors: Tominaga M,Caterina MJ,Malmberg AB,Rosen TA,Gilbert H,Skinner K,Raumann BE,Basbaum AI,Julius D

    更新日期:1998-09-01 00:00:00

  • Interferon-gamma promotes cholinergic differentiation of embryonic septal nuclei and adjacent basal forebrain.

    abstract::In cultured rat embryonic septal nuclei with adjacent basal forebrain, murine interferon-gamma (IFN gamma) produces a striking increase in choline acetyltransferase (ChAT) activity and mRNA. The effect of IFN gamma on cholinergic differentiation is more potent in E14 cultures than in older cultures. IFN gamma does not...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(94)90322-0

    authors: Jonakait GM,Wei R,Sheng ZL,Hart RP,Ni L

    更新日期:1994-05-01 00:00:00

  • Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations.

    abstract::Mesolimbic dopamine (DA) neurons play a central role in motivation and reward processing. Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is known about the circuits in which they are embedded. Using retrograde tracing, electrophysiology, optogenetics, and behavioral assay...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2017.12.022

    authors: Yang H,de Jong JW,Tak Y,Peck J,Bateup HS,Lammel S

    更新日期:2018-01-17 00:00:00

  • LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.

    abstract::LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using genetic and biochemical studies involving Lrrk loss-of-function mutants and Parkinson-related LRRK2(G2019S) gain-of-kinase function, we sh...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.08.022

    authors: Matta S,Van Kolen K,da Cunha R,van den Bogaart G,Mandemakers W,Miskiewicz K,De Bock PJ,Morais VA,Vilain S,Haddad D,Delbroek L,Swerts J,Chávez-Gutiérrez L,Esposito G,Daneels G,Karran E,Holt M,Gevaert K,Moechars DW,De

    更新日期:2012-09-20 00:00:00