Abstract:
:Synaptotagmin 7 (Syt7) was originally identified as a slow Ca2+ sensor for lysosome fusion, but its function at fast synapses is controversial. The paper by Luo and Südhof (2017) in this issue of Neuron shows that at the calyx of Held in the auditory brainstem Syt7 triggers asynchronous release during stimulus trains, resulting in reliable and temporally precise high-frequency transmission. Thus, a slow Ca2+ sensor contributes to the fast signaling properties of the calyx synapse.
journal_name
Neuronjournal_title
Neuronauthors
Chen C,Jonas Pdoi
10.1016/j.neuron.2017.05.011subject
Has Abstractpub_date
2017-05-17 00:00:00pages
694-696issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30412-9journal_volume
94pub_type
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