Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.

abstract：:Vaccinia virus can be used to infect cells in the CNS of frogs, Xenopus laevis, and Rana pipiens, both in vivo and in vitro. In vivo infections were accomplished by injection of viral solution into the tectal ventricle of stage 40-48 tadpoles or by local injections into distinct neural regions. Infections with high ti...

journal_title：Neuron

authors： Wu GY,Zou DJ,Koothan T,Cline HT

更新日期：1995-04-01 00:00:00

abstract：:People are embedded in social interaction that shapes their brains throughout lifetime. Instead of emerging from lower-level cognitive functions, social interaction could be the default mode via which humans communicate with their environment. Should this hypothesis be true, it would have profound implications on how ...

journal_title：Neuron

authors： Hari R,Henriksson L,Malinen S,Parkkonen L

更新日期：2015-10-07 00:00:00

abstract：:Ca(2+)-calmodulin (CaM) function was selectively disrupted in a specific subset of growth cones in transgenic Drosophila embryos in which a specific enhancer element drives the expression of the kinesin motor domain fused to a CaM antagonist peptide (kinesin-antagonist or KA, which blocks CaM binding to target protein...

journal_title：Neuron

authors： VanBerkum MF,Goodman CS

更新日期：1995-01-01 00:00:00

abstract：:Classical studies have related the spiking of selected neocortical neurons to behavior, but little is known about activity sampled from the entire neural population. We recorded from neurons selected independent of spiking, using cell-attached recordings and two-photon calcium imaging, in the barrel cortex of mice per...

journal_title：Neuron

authors： O'Connor DH,Peron SP,Huber D,Svoboda K

更新日期：2010-09-23 00:00:00

abstract：:Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions...

journal_title：Neuron

authors： Maruyama M,Shimada H,Suhara T,Shinotoh H,Ji B,Maeda J,Zhang MR,Trojanowski JQ,Lee VM,Ono M,Masamoto K,Takano H,Sahara N,Iwata N,Okamura N,Furumoto S,Kudo Y,Chang Q,Saido TC,Takashima A,Lewis J,Jang MK,Aoki I,

更新日期：2013-09-18 00:00:00

abstract：:The hippocampus is essential for spatiotemporal cognition. Sequences of neuronal activation provide a substrate for this fundamental function. At the behavioral timescale, these sequences have been shown to occur either in the presence of successive external landmarks or through internal mechanisms within an episodic ...

journal_title：Neuron

authors： Villette V,Malvache A,Tressard T,Dupuy N,Cossart R

更新日期：2015-10-21 00:00:00

abstract：:Voluntary spatial attention concentrates neural resources at the attended location. Here, we examined the effects of spatial attention on spatial position selectivity in humans. We measured population receptive fields (pRFs) using high-field functional MRI (fMRI) (7T) while subjects performed an attention-demanding ta...

journal_title：Neuron

authors： Klein BP,Harvey BM,Dumoulin SO

更新日期：2014-10-01 00:00:00

abstract：:In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP)...

journal_title：Neuron

authors： Dragoi G,Harris KD,Buzsáki G

更新日期：2003-08-28 00:00:00

abstract：:Diverse computations in the neocortex are aided by specialized GABAergic interneurons (INs), which selectively target other INs. However, much less is known about how these canonical disinhibitory circuit motifs contribute to network operations supporting spatial navigation and learning in the hippocampus. Using chron...

journal_title：Neuron

authors： Turi GF,Li WK,Chavlis S,Pandi I,O'Hare J,Priestley JB,Grosmark AD,Liao Z,Ladow M,Zhang JF,Zemelman BV,Poirazi P,Losonczy A

更新日期：2019-03-20 00:00:00

abstract：:Kainate receptors signal through both ionotropic and metabotropic pathways. The high-affinity subunits, GluK4 and GluK5, are unique among the five receptor subunits, as they do not form homomeric receptors but modify the properties of heteromeric assemblies. Disruption of the Grik4 gene locus resulted in a significant...

journal_title：Neuron

authors： Fernandes HB,Catches JS,Petralia RS,Copits BA,Xu J,Russell TA,Swanson GT,Contractor A

更新日期：2009-09-24 00:00:00

abstract：:The role of the target cell in neurotrophin-induced modifications of glutamatergic synaptic transmission was examined in cultured hippocampal neurons. Brain-derived neurotrophic factor (BDNF) induced rapid and persistent potentiation of evoked glutamate release when the postsynaptic neuron was glutamatergic, or excita...

journal_title：Neuron

authors： Schinder AF,Berninger B,Poo M

更新日期：2000-01-01 00:00:00

abstract：:The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is regulated during embryonic neural progenitor proliferation and neuronal migration through an inte...

journal_title：Neuron

authors： Singh KK,Ge X,Mao Y,Drane L,Meletis K,Samuels BA,Tsai LH

更新日期：2010-07-15 00:00:00

abstract：:Activation of kainate receptors causes Co2+ influx into neurons, type-2 astrocytes, and O-2A progenitor cells. Agonist-activated Co2+ uptake can be performed using cultured cells or fresh tissue slices. Based on the pattern of response to kainate, glutamate, and quisqualate, three functionally different kainate-activa...

journal_title：Neuron

authors： Pruss RM,Akeson RL,Racke MM,Wilburn JL

更新日期：1991-09-01 00:00:00

abstract：:The hippocampal CA2 subregion has a different anatomical connectivity pattern within the entorhino-hippocampal circuit than either the CA1 or CA3 subregion. Yet major differences in the neuronal activity patterns of CA2 compared with the other CA subregions have not been reported. We show that standard spatial and tem...

journal_title：Neuron

authors： Mankin EA,Diehl GW,Sparks FT,Leutgeb S,Leutgeb JK

更新日期：2015-01-07 00:00:00

abstract：:Propagation in higher animals requires the efficient and accurate display of innate mating behaviors. In Drosophila melanogaster, male courtship consists of a stereotypic sequence of behaviors involving multiple sensory modalities, such as vision, audition, and chemosensation. For example, taste bristles located in th...

journal_title：Neuron

authors： Bray S,Amrein H

更新日期：2003-09-11 00:00:00

abstract：:Lissencephaly (LIS), denoting a "smooth brain," is characterized by the absence of normal cerebral convolutions with abnormalities of cortical thickness. Pathogenic variants in over 20 genes are associated with LIS. The majority of posterior predominant LIS is caused by pathogenic variants in LIS1 (also known as PAFAH...

journal_title：Neuron

authors： Tsai MH,Muir AM,Wang WJ,Kang YN,Yang KC,Chao NH,Wu MF,Chang YC,Porter BE,Jansen LA,Sebire G,Deconinck N,Fan WL,Su SC,Chung WH,Almanza Fuerte EP,Mehaffey MG,University of Washington Center for Mendelian Genomics.,Ng CC

更新日期：2020-04-22 00:00:00

abstract：:The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for information processing in neural circuits. However, little is known about the spatial principles of E and I synaptic organization across the entire dendritic tree of mammalian neurons. We developed a new open-source reconstr...

journal_title：Neuron

authors： Iascone DM,Li Y,Sümbül U,Doron M,Chen H,Andreu V,Goudy F,Blockus H,Abbott LF,Segev I,Peng H,Polleux F

更新日期：2020-05-20 00:00:00

abstract：:Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilateral...

journal_title：Neuron

authors： Dougherty KJ,Zagoraiou L,Satoh D,Rozani I,Doobar S,Arber S,Jessell TM,Kiehn O

更新日期：2013-11-20 00:00:00

abstract：:Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN) and globus pallidus. Since STN is the target of deep brain stimula...

journal_title：Neuron

authors： Li Q,Ke Y,Chan DC,Qian ZM,Yung KK,Ko H,Arbuthnott GW,Yung WH

更新日期：2012-12-06 00:00:00

abstract：:Changes of ocular dominance in the visual cortex can be induced by visual manipulations during a critical period in early life. However, the role of critical period plasticity in normal development is unknown. Here we show that at the onset of this time window, the preferred orientations of individual cortical cells i...

journal_title：Neuron

authors： Wang BS,Sarnaik R,Cang J

更新日期：2010-01-28 00:00:00

abstract：:Mammalian neurogenesis is determined by an interplay between intrinsic genetic mechanisms and extrinsic cues such as growth factors. Here we have defined a signaling cascade, a MEK-C/EBP pathway, that is essential for cortical progenitor cells to become postmitotic neurons. Inhibition of MEK or of the C/EBP family of ...

journal_title：Neuron

authors： Ménard C,Hein P,Paquin A,Savelson A,Yang XM,Lederfein D,Barnabé-Heider F,Mir AA,Sterneck E,Peterson AC,Johnson PF,Vinson C,Miller FD

更新日期：2002-11-14 00:00:00

abstract：:Brain function relies on specificity of synaptic connectivity patterns among different classes of neurons. Yet, the substrates of specificity in complex neuropil remain largely unknown. We search for imprints of specificity in the layout of axonal and dendritic arbors from the rat neocortex. An analysis of 3D reconstr...

journal_title：Neuron

authors： Stepanyants A,Tamás G,Chklovskii DB

更新日期：2004-07-22 00:00:00

abstract：:In addition to the classical, center/surround receptive field of neurons in the lateral geniculate nucleus (LGN), there is an extraclassical, nonlinear surround that can strongly suppress LGN responses. This form of suppression likely plays an important role in adjusting the gain of LGN responses to visual stimuli. We...

journal_title：Neuron

authors： Alitto HJ,Usrey WM

更新日期：2008-01-10 00:00:00

abstract：:Antibodies were raised to three portions of the predicted sequences of Shaker, a gene that encodes a family of K+ channel components that are produced by the alternative splicing of transcripts. On immunoblots, the protein products appear to be 65,000-85,000 daltons in size. No smaller products were detected. Immunocy...

journal_title：Neuron

authors： Schwarz TL,Papazian DM,Carretto RC,Jan YN,Jan LY

更新日期：1990-01-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) mediate diverse signaling processes, including olfaction. G protein-coupled receptor kinases (GRKs) are important regulators of G protein signal transduction that specifically phosphorylate activated GPCRs to terminate signaling. Despite previously described roles for GRKs in GPCR s...

journal_title：Neuron

authors： Fukuto HS,Ferkey DM,Apicella AJ,Lans H,Sharmeen T,Chen W,Lefkowitz RJ,Jansen G,Schafer WR,Hart AC

更新日期：2004-05-27 00:00:00

abstract：:Advances in defining mechanisms of cortical development have been paralleled in recent years by an intense interest in translating these findings into greater insight of both childhood- and adult-onset cognitive and mental health disorders of developmental etiology. Successful integration of basic and clinical finding...

journal_title：Neuron

authors： Levitt P

更新日期：2005-05-05 00:00:00

abstract：:We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...

journal_title：Neuron

authors： Maconochie DJ,Zempel JM,Steinbach JH

更新日期：1994-01-01 00:00:00

abstract：:Voltage-gated calcium channels are well characterized at neuronal somata but less thoroughly understood at the presynaptic terminal where they trigger transmitter release. In order to elucidate how the intrinsic properties of presynaptic calcium channels influence synaptic function, we have made direct recordings of t...

journal_title：Neuron

authors： Forsythe ID,Tsujimoto T,Barnes-Davies M,Cuttle MF,Takahashi T

更新日期：1998-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many years to decades. Five AD biomarkers are sufficiently validated to have been incorporated into clinical diagnostic criteria and commonly used in...

journal_title：Neuron

authors： Jack CR Jr,Holtzman DM

更新日期：2013-12-18 00:00:00

abstract：:Injured peripheral neurons successfully activate a proregenerative transcriptional program to enable axon regeneration and functional recovery. How transcriptional regulators coordinate the expression of such program remains unclear. Here we show that hypoxia-inducible factor 1α (HIF-1α) controls multiple injury-induc...

journal_title：Neuron

authors： Cho Y,Shin JE,Ewan EE,Oh YM,Pita-Thomas W,Cavalli V

更新日期：2015-11-18 00:00:00