Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex.

abstract：:Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data f...

journal_title：Neuron

authors： Geschwind DH

更新日期：2003-10-30 00:00:00

abstract：:Synaptic plasticity during critical periods of development requires intact inhibitory circuitry. We report that subplate neurons are needed both for maturation of inhibition and for the proper sign of ocular dominance (OD) plasticity. Removal of subplate neurons prevents the developmental upregulation of genes involve...

journal_title：Neuron

authors： Kanold PO,Shatz CJ

更新日期：2006-09-07 00:00:00

abstract：:In the developing mammalian retina, spontaneous waves of action potentials are present in the ganglion cell layer weeks before vision. These waves are known to be generated by a synaptically connected network of amacrine cells and retinal ganglion cells, and exhibit complex spatiotemporal patterns, characterized by sh...

journal_title：Neuron

authors： Feller MB,Butts DA,Aaron HL,Rokhsar DS,Shatz CJ

更新日期：1997-08-01 00:00:00

abstract：:Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus and indirectly from the auditory cortex. Here we show in the cortico-amygdala pathway that learned fear occludes electricall...

journal_title：Neuron

authors： Tsvetkov E,Carlezon WA,Benes FM,Kandel ER,Bolshakov VY

更新日期：2002-04-11 00:00:00

abstract：:We provide physiological, pharmacological, and structural evidence that axons of hippocampal principal cells are electrically coupled, with prepotentials or spikelets forming the physiological substrate of electrical coupling as observed in cell somata. Antidromic activation of neighboring axons induced somatic spikel...

journal_title：Neuron

authors： Schmitz D,Schuchmann S,Fisahn A,Draguhn A,Buhl EH,Petrasch-Parwez E,Dermietzel R,Heinemann U,Traub RD

更新日期：2001-09-13 00:00:00

abstract：:The amplitudes and kinetics of miniature excitatory synaptic currents (MESCs) in mammalian central neurons vary widely. It is unclear whether this variability occurs at each synapse or arises from differences among a heterogeneous population of synapses. Furthermore, it is not known how variability in these currents w...

journal_title：Neuron

authors： Murphy TH,Baraban JM,Wier WG

更新日期：1995-07-01 00:00:00

abstract：:During the development of forebrain connectivity, ascending thalamocortical and descending corticofugal axons first intermingle at the pallial-subpallial boundary to form the internal capsule (IC). However, the identity of molecular cues that guide these axons remains largely unknown. Here, we show that the transmembr...

journal_title：Neuron

authors： Mandai K,Reimert DV,Ginty DD

更新日期：2014-07-02 00:00:00

abstract：:Recent studies indicate that long interspersed nuclear element-1 (L1) are mobilized in the genome of human neural progenitor cells and enhanced in Rett syndrome and ataxia telangiectasia. However, whether aberrant L1 retrotransposition occurs in mental disorders is unknown. Here, we report high L1 copy number in schiz...

journal_title：Neuron

authors： Bundo M,Toyoshima M,Okada Y,Akamatsu W,Ueda J,Nemoto-Miyauchi T,Sunaga F,Toritsuka M,Ikawa D,Kakita A,Kato M,Kasai K,Kishimoto T,Nawa H,Okano H,Yoshikawa T,Kato T,Iwamoto K

更新日期：2014-01-22 00:00:00

abstract：:Sleep has many inherent benefits, including an important role in memory consolidation. In this issue of Neuron, Ngo et al. (2013b) demonstrate that appropriately timed sounds delivered during sleep can invigorate electrophysiological oscillations conducive to memory stabilization. ...

journal_title：Neuron

authors： Oudiette D,Santostasi G,Paller KA

更新日期：2013-05-08 00:00:00

abstract：:Neuronal population responses can vary across trials as a result of differences in the relative timing of internal brain processes. In this issue of Neuron, Williams et al. (2020) present an algorithm for inferring and inverting such trial-to-trial differences, thereby revealing an a priori hidden, precise temporal st...

journal_title：Neuron

authors： Okun M

更新日期：2020-01-22 00:00:00

abstract：:Studies on postmortem brains from Parkinson's patients reveal elevated iron in the substantia nigra (SN). Selective cell death in this brain region is associated with oxidative stress, which may be exacerbated by the presence of excess iron. Whether iron plays a causative role in cell death, however, is controversial....

journal_title：Neuron

authors： Kaur D,Yantiri F,Rajagopalan S,Kumar J,Mo JQ,Boonplueang R,Viswanath V,Jacobs R,Yang L,Beal MF,DiMonte D,Volitaskis I,Ellerby L,Cherny RA,Bush AI,Andersen JK

更新日期：2003-03-27 00:00:00

abstract：:NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor-expressing cells, and the majority of native receptors are triheteromers containing two GluN1 and two different GluN2. In contrast to diheterome...

journal_title：Neuron

authors： Hansen KB,Ogden KK,Yuan H,Traynelis SF

更新日期：2014-03-05 00:00:00

abstract：:We have made little recent progress developing effective new treatments for neuropsychiatric and neurodevelopmental disorders. Novel molecular mechanisms have been identified, but have not translated into the clinic. We suggest an alternative: combinations of treatments targeting different aspects of final common path...

journal_title：Neuron

authors： Murphy DG,Goldman M,Loth E,Spooren W

更新日期：2014-11-05 00:00:00

abstract：:Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental question in addiction biology is why exogenous opiate drugs have a high liability for inducing tolerance and addiction while native ligands do not. Studies indicate that highly addictive opiate d...

journal_title：Neuron

authors： Whistler JL,Chuang HH,Chu P,Jan LY,von Zastrow M

更新日期：1999-08-01 00:00:00

abstract：:What underlies the large variation in mEPSC amplitude in the auditory system? And is this variability important? In this issue of Neuron, Li et al. (2014) address the significance of large mEPSCs to auditory processing and Chapochnikov et al. (2014) describe a novel mechanism underlying them. ...

journal_title：Neuron

authors： Lv C,Zenisek D

更新日期：2014-09-17 00:00:00

abstract：:Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a chang...

journal_title：Neuron

authors： Vinck M,Batista-Brito R,Knoblich U,Cardin JA

更新日期：2015-05-06 00:00:00

abstract：:The posterior septum consisting of the triangular septum (TS) and the bed nucleus of the anterior commissure (BAC) is predominantly linked with the medial habenula (MHb) and has been implicated in the control of anxiety and fear responses. However, its anatomical and functional linkage has largely remained elusive. We...

journal_title：Neuron

authors： Yamaguchi T,Danjo T,Pastan I,Hikida T,Nakanishi S

更新日期：2013-05-08 00:00:00

abstract：:Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. We examined the effects of cadherin blockage on synaptogenesis in cultured hippocampal neurons. This blockade resulted in alterations of dendritic spin...

journal_title：Neuron

authors： Togashi H,Abe K,Mizoguchi A,Takaoka K,Chisaka O,Takeichi M

更新日期：2002-07-03 00:00:00

abstract：:Nematode degenerins have been implicated in touch sensitivity and other forms of mechanosensation. Certain mutations in several degenerin genes cause the swelling, vacuolation, and death of neurons, and other mutations in the muscle degenerin gene unc-105 cause hypercontraction. Here, we confirm that unc-105 encodes a...

journal_title：Neuron

authors： García-Añoveros J,García JA,Liu JD,Corey DP

更新日期：1998-06-01 00:00:00

abstract：:Microcircuits in different brain areas share similar architectural and biophysical properties with compact motor networks known as central pattern generators (CPGs). Consequently, CPGs have been suggested as valuable biological models for understanding of microcircuit dynamics and particularly, their synchronization. ...

journal_title：Neuron

authors： Szücs A,Huerta R,Rabinovich MI,Selverston AI

更新日期：2009-02-12 00:00:00

abstract：:Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a n...

journal_title：Neuron

authors： Luo HR,Saiardi A,Nagata E,Ye K,Yu H,Jung TS,Luo X,Jain S,Sawa A,Snyder SH

更新日期：2001-08-16 00:00:00

abstract：:The capsaicin receptor, TRPV1, is regulated by phosphatidylinositol-4,5-bisphosphate (PIP(2)), although the precise nature of this effect (i.e., positive or negative) remains controversial. Here, we reconstitute purified TRPV1 into artificial liposomes, where it is gated robustly by capsaicin, protons, spider toxins, ...

journal_title：Neuron

authors： Cao E,Cordero-Morales JF,Liu B,Qin F,Julius D

更新日期：2013-02-20 00:00:00

abstract：:The Mg2+ block of NMDA-type glutamate receptors (NMDARs) is crucial to their function as synaptic coincidence detectors. An analysis of Drosophila expressing a Mg2+-independent NMDAR by in this issue of Neuron concludes that the Mg2+ block is required primarily for long-term memory. ...

journal_title：Neuron

authors： Tabone CJ,Ramaswami M

更新日期：2012-06-07 00:00:00

abstract：:Studies of resting-state activity in the brain have provoked critical questions about the brain's functional organization, but the biological basis of this activity is not clear. Specifically, the relationships between interregional correlations in resting-state measures of activity, neuronal functional connectivity a...

journal_title：Neuron

authors： Wang Z,Chen LM,Négyessy L,Friedman RM,Mishra A,Gore JC,Roe AW

更新日期：2013-06-19 00:00:00

abstract：:Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot...

journal_title：Neuron

authors： Giniger E

更新日期：1998-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions as translational repressor. We show that miR-125b and miR-132, as well as several other miRNAs, are associated with FMRP in mouse brain. miR...

journal_title：Neuron

authors： Edbauer D,Neilson JR,Foster KA,Wang CF,Seeburg DP,Batterton MN,Tada T,Dolan BM,Sharp PA,Sheng M

更新日期：2010-02-11 00:00:00

abstract：:Bcl-2 is a major regulator of programmed cell death, a critical process in shaping the developing nervous system. To assess whether Bcl-2 is involved in regulating neuronal survival and in mediating the neuroprotective action of neurotrophic factors, we generated Bcl-2-deficient mice. At birth, the number of facial mo...

journal_title：Neuron

authors： Michaelidis TM,Sendtner M,Cooper JD,Airaksinen MS,Holtmann B,Meyer M,Thoenen H

更新日期：1996-07-01 00:00:00

abstract：:To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the brain reward system, we undertook a phenotype-driven approach using genome-wide microarray profiling of striatal transcripts from three genetic and one pharmacological mouse models of psychostimulant or dopamine supersensitivity...

journal_title：Neuron

authors： Yao WD,Gainetdinov RR,Arbuckle MI,Sotnikova TD,Cyr M,Beaulieu JM,Torres GE,Grant SG,Caron MG

更新日期：2004-02-19 00:00:00

abstract：:The netrin UNC-6 repels motor axons by activating the UNC-5 receptor alone or in combination with the UNC-40/DCC receptor. In a genetic screen for C. elegans mutants exhibiting partial defects in motor axon projections, we isolated the max-1 gene (required for motor neuron axon guidance). max-1 loss-of-function mutati...

journal_title：Neuron

authors： Huang X,Cheng HJ,Tessier-Lavigne M,Jin Y

更新日期：2002-05-16 00:00:00

abstract：:We show here that antisense MAP2 oligonucleotides inhibit neurite outgrowth in cultured cerebellar macroneurons. Unlike control neurons, which first extend a lamellipodial veil followed by a consolidation phase during which the cells extend minor neurites, MAP2-suppressed cells persist with lamellipodia and later beco...

journal_title：Neuron

authors： Caceres A,Mautino J,Kosik KS

更新日期：1992-10-01 00:00:00