Developmental neurobiology and clinical disorders: lost in translation?

Abstract:

:Advances in defining mechanisms of cortical development have been paralleled in recent years by an intense interest in translating these findings into greater insight of both childhood- and adult-onset cognitive and mental health disorders of developmental etiology. Successful integration of basic and clinical findings have been applied to monogenic disorders. The greater challenge lies in studying cortical development in the context of gene x environment interactions, which underlie the pathogenesis of the most common neurodevelopmental disorders. This can occur through an improved delineation of pathophysiological characteristics unique to specific complex disorders and the application of this information to the refinement of the most relevant model systems.

journal_name

Neuron

journal_title

Neuron

authors

Levitt P

doi

10.1016/j.neuron.2005.04.015

subject

Has Abstract

pub_date

2005-05-05 00:00:00

pages

407-12

issue

3

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(05)00351-X

journal_volume

46

pub_type

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