Agonist-activated cobalt uptake identifies divalent cation-permeable kainate receptors on neurons and glial cells.

abstract：:Synapse-to-nucleus signaling leading to CREB-mediated transcription is important for neuronal plasticity. Nuclear CREB phosphorylation at Ser133 allows convergence of multiple kinase pathways driven by neuronal activity and links them to transcriptional activation. But, can various pathways share a common effector mec...

journal_title：Neuron

authors： Deisseroth K,Tsien RW

更新日期：2002-04-11 00:00:00

abstract：:In this issue of Neuron, Oh and Gu (2013) present a model in which intimately related embryonic nerves and blood vessels are patterned independently in response to different guidance cues from a central organizer: the whisker. ...

journal_title：Neuron

authors： Chauvet S,Mann F

更新日期：2013-10-16 00:00:00

abstract：:Recently, we found that electrical stimulation of motor cortex caused monkeys to make coordinated, complex movements. These evoked movements were arranged across the cortex in a map of spatial locations to which the hand moved. We suggest that some of the subdivisions previously described within primary motor and prem...

journal_title：Neuron

authors： Graziano MS,Taylor CS,Moore T,Cooke DF

更新日期：2002-10-24 00:00:00

abstract：:Circadian clocks consist of transcriptional feedback loops housed in interdependent pacemaker neurons. Yet little is known about the neuronal output components essential for rhythmic behavior. Drosophila mutants of a putative ion channel, narrow abdomen (na), exhibit poor circadian rhythms and suppressed daylight acti...

journal_title：Neuron

authors： Lear BC,Lin JM,Keath JR,McGill JJ,Raman IM,Allada R

更新日期：2005-12-22 00:00:00

abstract：:The brain has often been described, quite accurately, as one of the most complex objects in the natural world. Understanding its workings, to say nothing about intervening in them, is among the hardest problems in science. While this makes the challenge all the more enticing, in the short term, it acts to limit the im...

journal_title：Neuron

authors： Sinha P

更新日期：2016-11-02 00:00:00

abstract：:Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...

journal_title：Neuron

authors： Lammel S,Ion DI,Roeper J,Malenka RC

更新日期：2011-06-09 00:00:00

abstract：:Cognitive control is subjectively costly, suggesting that engagement is modulated in relationship to incentive state. Dopamine appears to play key roles. In particular, dopamine may mediate cognitive effort by two broad classes of functions: (1) modulating the functional parameters of working memory circuits subservin...

journal_title：Neuron

authors： Westbrook A,Braver TS

更新日期：2016-02-17 00:00:00

abstract：:It has been unclear whether the hippocampus is uniquely important for episodic memory (memory for events that are specific to time and place) or whether the hippocampus is also important for learning and remembering facts (semantic memory). In two studies, we assessed the capacity for semantic memory in patients with ...

journal_title：Neuron

authors： Manns JR,Hopkins RO,Squire LR

更新日期：2003-04-10 00:00:00

abstract：:Striatal dopamine plays key roles in our normal and pathological goal-directed actions. To understand dopamine function, much attention has focused on how midbrain dopamine neurons modulate their firing patterns. However, we identify a presynaptic mechanism that triggers dopamine release directly, bypassing activity i...

journal_title：Neuron

authors： Threlfell S,Lalic T,Platt NJ,Jennings KA,Deisseroth K,Cragg SJ

更新日期：2012-07-12 00:00:00

abstract：:About two-thirds of the antibodies to the nicotinic acetylcholine (ACh) receptor in patients with the autoimmune disease myasthenia gravis bind to the main immunogenic region (MIR). This is small, well-defined region on each of the two alpha subunits, containing residues 67-76 (alpha 67-76). By determining the structu...

journal_title：Neuron

authors： Beroukhim R,Unwin N

更新日期：1995-08-01 00:00:00

abstract：:Primates can learn to recognize a virtually limitless number of visual objects. A candidate neural substrate for this adult plasticity is the inferior temporal cortex (ITC). Using a large stimulus set, we explored the impact that long-term experience has on the response properties of two classes of neurons in ITC: bro...

journal_title：Neuron

authors： Woloszyn L,Sheinberg DL

更新日期：2012-04-12 00:00:00

abstract：:Phosphatidylinositol 3-kinase (PI3K)-dependent phosphoinositide signaling has been implicated in diverse cellular systems coupled to receptors for many different ligands, but the extent to which it functions in sensory transduction is yet to be determined. We now report that blocking PI3K activity increases odorant-ev...

journal_title：Neuron

authors： Spehr M,Wetzel CH,Hatt H,Ache BW

更新日期：2002-02-28 00:00:00

abstract：:Input-timing-dependent plasticity (ITDP) is a circuit-based synaptic learning rule by which paired activation of entorhinal cortical (EC) and Schaffer collateral (SC) inputs to hippocampal CA1 pyramidal neurons (PNs) produces a long-term enhancement of SC excitation. We now find that paired stimulation of EC and SC in...

journal_title：Neuron

authors： Leroy F,Brann DH,Meira T,Siegelbaum SA

更新日期：2017-08-30 00:00:00

abstract：:The primate dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) focus attention on relevant signals and suppress noise in cognitive tasks. However, their synaptic interactions and unique roles in cognitive control are unknown. We report that two distinct pathways to DLPFC area 9, one from the ne...

journal_title：Neuron

authors： Medalla M,Barbas H

更新日期：2009-02-26 00:00:00

abstract：:Accumulation of specific proteins at synaptic structures is essential for synapse assembly and function, but mechanisms regulating local protein enrichment remain poorly understood. At the neuromuscular junction (NMJ), subsynaptic nuclei underlie motor axon terminals within extrafusal muscle fibers and are transcripti...

journal_title：Neuron

authors： Hippenmeyer S,Huber RM,Ladle DR,Murphy K,Arber S

更新日期：2007-09-06 00:00:00

abstract：:Statistical regularities in the environment create prior beliefs that we rely on to optimize our behavior when sensory information is uncertain. Bayesian theory formalizes how prior beliefs can be leveraged and has had a major impact on models of perception, sensorimotor function, and cognition. However, it is not kno...

journal_title：Neuron

authors： Sohn H,Narain D,Meirhaeghe N,Jazayeri M

更新日期：2019-09-04 00:00:00

abstract：:The subunit stoichiometry of the mammalian K+ channel KV1.1 (RCK1) was examined by linking together the coding sequences of 2-5 K+ channel subunits in a single open reading frame and tagging the expression of individual subunits with a mutation (Y379K or Y379R) that altered the sensitivity of the channel to block by e...

journal_title：Neuron

authors： Liman ER,Tytgat J,Hess P

更新日期：1992-11-01 00:00:00

abstract：:The online maintenance and manipulation of information in working memory (WM) is essential for guiding behavior based on our goals. Understanding how WM alters sensory processing in pursuit of different behavioral objectives is therefore crucial to establish the neural basis of our goal-directed behavior. Here we show...

journal_title：Neuron

authors： Bahmani Z,Daliri MR,Merrikhi Y,Clark K,Noudoost B

更新日期：2018-02-21 00:00:00

abstract：:We describe the genetic and kinetic defects in a congenital myasthenic syndrome caused by heteroallelic mutations of the acetylcholine receptor (AChR) epsilon subunit gene. The mutations are an in-frame duplication of six residues in the long cytoplasmic loop (epsilon1254ins18) and a cysteine-loop null mutation (epsil...

journal_title：Neuron

authors： Milone M,Wang HL,Ohno K,Prince R,Fukudome T,Shen XM,Brengman JM,Griggs RC,Sine SM,Engel AG

更新日期：1998-03-01 00:00:00

abstract：:A fundamental property of neuronal circuits is the ability to adapt to altered sensory inputs. It is well established that the functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, the degree to which structural plasticity in inhibitory neu...

journal_title：Neuron

authors： Keck T,Scheuss V,Jacobsen RI,Wierenga CJ,Eysel UT,Bonhoeffer T,Hübener M

更新日期：2011-09-08 00:00:00

abstract：:Cellular Ca2+ buffers determine amplitude and diffusional spread of neuronal Ca2+ signals. Fixed Ca2+ buffers tend to retard the signal and to lower the apparent diffusion coefficient (D(app)) of Ca2+, whereas mobile buffers contribute to Ca2+ redistribution. To estimate the impact of the expression of specific Ca2+-b...

journal_title：Neuron

authors： Gabso M,Neher E,Spira ME

更新日期：1997-03-01 00:00:00

abstract：:The formation, function, and plasticity of synapses require dynamic changes in synaptic receptor composition. Here, we identify the sorting receptor SorCS1 as a key regulator of synaptic receptor trafficking. Four independent proteomic analyses identify the synaptic adhesion molecule neurexin and the AMPA glutamate re...

journal_title：Neuron

authors： Savas JN,Ribeiro LF,Wierda KD,Wright R,DeNardo-Wilke LA,Rice HC,Chamma I,Wang YZ,Zemla R,Lavallée-Adam M,Vennekens KM,O'Sullivan ML,Antonios JK,Hall EA,Thoumine O,Attie AD,Yates JR 3rd,Ghosh A,de Wit J

更新日期：2015-08-19 00:00:00

abstract：:Formation of the normal mammalian cerebral cortex requires the migration of GABAergic inhibitory interneurons from an extracortical origin, the lateral ganglionic eminence (LGE). Mechanisms guiding the migratory direction of these neurons, or other neurons in the neocortex, are not well understood. We have used an exp...

journal_title：Neuron

authors： Zhu Y,Li H,Zhou L,Wu JY,Rao Y

更新日期：1999-07-01 00:00:00

abstract：:Somatic mutation of the MTOR gene is a genetic etiology of focal malformations of cortical development. In this issue of Neuron, Park et al. (2018) identify defective autophagy-dependent ciliogenesis/Wnt signaling as an underlying mechanism affecting neuronal migration and cortical lamination. ...

journal_title：Neuron

authors： Di Nardo A,Sahin M

更新日期：2018-07-11 00:00:00

abstract：:Perceptual learning is a lifelong process. We begin by encoding information about the basic structure of the natural world and continue to assimilate information about specific patterns with which we become familiar. The specificity of the learning suggests that all areas of the cerebral cortex are plastic and can rep...

journal_title：Neuron

authors： Gilbert CD,Sigman M,Crist RE

更新日期：2001-09-13 00:00:00

abstract：:Yoon et al. (2017) uncover a key role for the m6A RNA mark in regulating the timing of cerebral cortex development in mouse and human. This discovery opens new avenues of exploration into how the epitranscriptome helps orchestrate central nervous system formation. ...

journal_title：Neuron

authors： Boles NC,Temple S

更新日期：2017-11-15 00:00:00

abstract：:Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein. There are currently no disease-modifying therapies available, but approaches that target proximally in disease pathogenesis hold gre...

journal_title：Neuron

authors： Tabrizi SJ,Ghosh R,Leavitt BR

更新日期：2019-03-06 00:00:00

abstract：:Binding between DIP and Dpr neuronal recognition proteins has been proposed to regulate synaptic connections between lamina and medulla neurons in the Drosophila visual system. Each lamina neuron was previously shown to express many Dprs. Here, we demonstrate, by contrast, that their synaptic partners typically expres...

journal_title：Neuron

authors： Cosmanescu F,Katsamba PS,Sergeeva AP,Ahlsen G,Patel SD,Brewer JJ,Tan L,Xu S,Xiao Q,Nagarkar-Jaiswal S,Nern A,Bellen HJ,Zipursky SL,Honig B,Shapiro L

更新日期：2018-12-19 00:00:00

abstract：:The mechanisms generating precise connections between specific thalamic nuclei and cortical areas remain poorly understood. Using axon tracing analysis of ephrin/Eph mutant mice, we provide in vivo evidence that Eph receptors in the thalamus and ephrins in the cortex control intra-areal topographic mapping of thalamoc...

journal_title：Neuron

authors： Dufour A,Seibt J,Passante L,Depaepe V,Ciossek T,Frisén J,Kullander K,Flanagan JG,Polleux F,Vanderhaeghen P

更新日期：2003-07-31 00:00:00

abstract：:We developed a large-scale dynamical model of the macaque neocortex, which is based on recently acquired directed- and weighted-connectivity data from tract-tracing experiments, and which incorporates heterogeneity across areas. A hierarchy of timescales naturally emerges from this system: sensory areas show brief, tr...

journal_title：Neuron

authors： Chaudhuri R,Knoblauch K,Gariel MA,Kennedy H,Wang XJ

更新日期：2015-10-21 00:00:00