Three-dimensional location of the main immunogenic region of the acetylcholine receptor.

abstract：:Neocortical excitatory and inhibitory neurons derive from distinct progenitor domains during embryonic development and migrate to their final positions, where they assemble into functional circuits. This process appears to be influenced by lineage relationships among locally born excitatory neurons, raising the intrig...

journal_title：Neuron

authors： Turrero García M,Mazzola E,Harwell CC

更新日期：2016-10-05 00:00:00

abstract：:Many animals guide their movements using optic flow, the displacement of stationary objects across the retina caused by self-motion. How do animals selectively synthesize a global motion pattern from its local motion components? To what extent does this feature selectivity rely on circuit mechanisms versus dendritic p...

journal_title：Neuron

authors： Barnhart EL,Wang IE,Wei H,Desplan C,Clandinin TR

更新日期：2018-10-10 00:00:00

abstract：:Homomeric assembly of Kir5.1, an inward-rectifying K+ channel subunit, is believed to be nonfunctional, although the subunit exists abundantly in the brain. We show that HEK293T cells cotransfected with Kir5.1 and PSD-95 exhibit a Ba(2+)-sensitive inward-rectifying K+ current. Kir5.1 coexpressed with PSD-95 located on...

journal_title：Neuron

authors： Tanemoto M,Fujita A,Higashi K,Kurachi Y

更新日期：2002-04-25 00:00:00

abstract：:MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions as translational repressor. We show that miR-125b and miR-132, as well as several other miRNAs, are associated with FMRP in mouse brain. miR...

journal_title：Neuron

authors： Edbauer D,Neilson JR,Foster KA,Wang CF,Seeburg DP,Batterton MN,Tada T,Dolan BM,Sharp PA,Sheng M

更新日期：2010-02-11 00:00:00

abstract：:Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's disease (AD) bring cholesterol to the forefront of AD research. Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and t...

journal_title：Neuron

authors： Wolozin B

更新日期：2004-01-08 00:00:00

abstract：:The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV cargo occurs at the plasma membrane. Activity-dependent bulk endocytosis (ADBE) ...

journal_title：Neuron

authors： Nicholson-Fish JC,Kokotos AC,Gillingwater TH,Smillie KJ,Cousin MA

更新日期：2015-12-02 00:00:00

abstract：:Despite tremendous progress in the study of voltage-gated channels, the molecular mechanism underlying voltage sensing has remained a matter of debate. We review five new studies that make major progress in the field. The studies employ a battery of distinct approaches that have the common aim of measuring the motion ...

journal_title：Neuron

authors： Tombola F,Pathak MM,Isacoff EY

更新日期：2005-12-08 00:00:00

abstract：:Spontaneous activity patterns in the developing retina appear important for the functional organization of the visual system. We show here that an absence of early retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) is associated with both gain and loss of functional organiz...

journal_title：Neuron

authors： Grubb MS,Rossi FM,Changeux JP,Thompson ID

更新日期：2003-12-18 00:00:00

abstract：:Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limit...

journal_title：Neuron

authors： Mennerick S,Matthews G

更新日期：1996-12-01 00:00:00

abstract：:N-type calcium channels are critical for pain transduction. Inhibitors of these channels are powerful analgesics, but clinical use of current N-type blockers remains limited by undesirable actions in other regions of the nervous system. We now demonstrate that a unique splice isoform of the N-type channel is restricte...

journal_title：Neuron

authors： Bell TJ,Thaler C,Castiglioni AJ,Helton TD,Lipscombe D

更新日期：2004-01-08 00:00:00

abstract：:Local axon degeneration is a common pathological feature of many neurodegenerative diseases and peripheral neuropathies. While it is believed to operate with an apoptosis-independent molecular program, the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons,...

journal_title：Neuron

authors： Zhai Q,Wang J,Kim A,Liu Q,Watts R,Hoopfer E,Mitchison T,Luo L,He Z

更新日期：2003-07-17 00:00:00

abstract：:Myelinated fibers are organized into distinct domains that are necessary for saltatory conduction. These domains include the nodes of Ranvier and the flanking paranodal regions where glial cells closely appose and form specialized septate-like junctions with axons. These junctions contain a Drosophila Neurexin IV-rela...

journal_title：Neuron

authors： Bhat MA,Rios JC,Lu Y,Garcia-Fresco GP,Ching W,St Martin M,Li J,Einheber S,Chesler M,Rosenbluth J,Salzer JL,Bellen HJ

更新日期：2001-05-01 00:00:00

abstract：:A fundamental question about the neural correlates of attention concerns the earliest sensory processing stage that it can affect. We addressed this issue by recording magnetoencephalography (MEG) signals while subjects performed detection tasks, which required employment of spatial or nonspatial attention, in auditor...

journal_title：Neuron

authors： Poghosyan V,Ioannides AA

更新日期：2008-06-12 00:00:00

abstract：:Dopamine (DA) transmission mediates numerous aspects of behavior. Although DA release is strongly linked to firing of DA neurons, recent developments indicate the importance of presynaptic modulation at striatal dopaminergic terminals. The endocannabinoid (eCB) system regulates DA release and is a canonical gatekeeper...

journal_title：Neuron

authors： Mateo Y,Johnson KA,Covey DP,Atwood BK,Wang HL,Zhang S,Gildish I,Cachope R,Bellocchio L,Guzmán M,Morales M,Cheer JF,Lovinger DM

更新日期：2017-12-06 00:00:00

abstract：:In this issue of Neuron, Luo and Maunsell (2018) use signal detection theory to demonstrate that the modulatory effects of attention on neuronal responses in the lateral prefrontal cortex during change detection can be due to changes in an observer's sensitivity or shifts in their response criterion. ...

journal_title：Neuron

authors： Martinez-Trujillo J,Gulli RA

更新日期：2018-03-21 00:00:00

abstract：:Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) report in Nature that primates evolved novel transcriptional responses to neuronal activity, including induction of musclin/osteocrin (OSTN), which may regulate specialized aspects of prim...

journal_title：Neuron

authors： Pollen AA,Kriegstein AR

更新日期：2016-11-23 00:00:00

abstract：:Sweet and bitter taste distinguishes good food sources from potential toxins, but what happens when these tastants are mixed? In this issue of Neuron, Jeong et al. (2013) show that in Drosophila, bitter compounds act through an extracellular odorant-binding protein to inhibit sweet-responsive neurons and block the res...

journal_title：Neuron

authors： Lvovskaya S,Smith DP

更新日期：2013-08-21 00:00:00

abstract：:Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum. To assess the role of Satb2 in neurons, we analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ ...

journal_title：Neuron

authors： Alcamo EA,Chirivella L,Dautzenberg M,Dobreva G,Fariñas I,Grosschedl R,McConnell SK

更新日期：2008-02-07 00:00:00

abstract：:Innate defense behaviors (IDBs) evoked by threatening sensory stimuli are essential for animal survival. Although subcortical circuits are implicated in IDBs, it remains largely unclear whether sensory cortex modulates IDBs and what the underlying neural pathways are. Here, we show that optogenetic silencing of cortic...

journal_title：Neuron

authors： Liang F,Xiong XR,Zingg B,Ji XY,Zhang LI,Tao HW

更新日期：2015-05-06 00:00:00

abstract：:The dynamic interactions between hippocampus and amygdala are critical for emotional memory. Theta synchrony between these structures occurs during fear memory retrieval and may facilitate synaptic plasticity, but the cellular mechanisms are unknown. We report that interneurons of the mouse basal amygdala are activate...

journal_title：Neuron

authors： Bazelot M,Bocchio M,Kasugai Y,Fischer D,Dodson PD,Ferraguti F,Capogna M

更新日期：2015-09-23 00:00:00

abstract：:In this issue of Neuron, Costa et al. (2017) introduce a theoretical framework that predicts the ratio of presynaptic and postsynaptic changes taking place during LTP and LTD and show that these processes co-operate so as to optimize the postsynaptic response statistics. ...

journal_title：Neuron

authors： Poirazi P,Kastellakis G

更新日期：2017-09-27 00:00:00

abstract：:The dopamine D3 receptor is expressed primarily in regions of the brain that are thought to influence motivation and motor functions. To specify in vivo D3 receptor function, we generated mutant mice lacking this receptor. Our analysis indicates that in a novel environment, D3 mutant mice are transiently more active t...

journal_title：Neuron

authors： Xu M,Koeltzow TE,Santiago GT,Moratalla R,Cooper DC,Hu XT,White NM,Graybiel AM,White FJ,Tonegawa S

更新日期：1997-10-01 00:00:00

abstract：:The panoply of cognitive, affective, motivational, and social functions that underpin everyday human experience requires precisely choreographed patterns of interaction between networked brain regions. Perhaps not surprisingly, diverse forms of psychopathology are characterized by breakdowns in these interregional rel...

journal_title：Neuron

authors： Buckholtz JW,Meyer-Lindenberg A

更新日期：2012-06-21 00:00:00

abstract：:Ionic currents were recorded from Xenopus oocytes injected with RNA isolated from chick or mouse brain. Three currents were studied: a rapid tetrodotoxin-sensitive Na+ current (Ina), an early outward K+ current sensitive to 4-aminopyridine (IA), and an inward current activated by the excitatory amino acid receptor ago...

journal_title：Neuron

authors： Lotan I,Volterra A,Dash P,Siegelbaum SA,Goelet P

更新日期：1988-12-01 00:00:00

abstract：:For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ...

journal_title：Neuron

authors： McAllister AK,van de Water J

更新日期：2009-10-15 00:00:00

abstract：:The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in inform...

journal_title：Neuron

authors： Jackman SL,Regehr WG

更新日期：2017-05-03 00:00:00

abstract：:Uptake and transneuronal passage of wild-type and attenuated strains of a swine alpha-herpesvirus (pseudorabies [PRV]) were examined in rat visual projections. Both strains of virus infected subpopulations of retinal ganglion cells and passed transneuronally to infect retino-recipient neurons in the forebrain. However...

journal_title：Neuron

authors： Card JP,Whealy ME,Robbins AK,Moore RY,Enquist LW

更新日期：1991-06-01 00:00:00

abstract：:Experimental evidence shows that the inability to attribute mental states, such as desires and beliefs, to self and others (mentalizing) explains the social and communication impairments of individuals with autism. Brain imaging studies in normal volunteers highlight a circumscribed network that is active during menta...

journal_title：Neuron

authors： Frith U

更新日期：2001-12-20 00:00:00

abstract：:It has been unclear whether the hippocampus is uniquely important for episodic memory (memory for events that are specific to time and place) or whether the hippocampus is also important for learning and remembering facts (semantic memory). In two studies, we assessed the capacity for semantic memory in patients with ...

journal_title：Neuron

authors： Manns JR,Hopkins RO,Squire LR

更新日期：2003-04-10 00:00:00

abstract：:Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...

journal_title：Neuron

authors： Quinlan EM,Lebel D,Brosh I,Barkai E

更新日期：2004-01-22 00:00:00