Abstract:
:A fundamental question about the neural correlates of attention concerns the earliest sensory processing stage that it can affect. We addressed this issue by recording magnetoencephalography (MEG) signals while subjects performed detection tasks, which required employment of spatial or nonspatial attention, in auditory or visual modality. Using distributed source analysis of MEG signals, we found that, contrary to previous studies that used equivalent current dipole (ECD) analysis, spatial attention enhanced the initial feedforward response in the primary visual cortex (V1) at 55-90 ms. We also found attentional modulation of the putative primary auditory cortex (A1) activity at 30-50 ms. Furthermore, we reproduced our findings using ECD modeling guided by the results of distributed source analysis and suggest a reason why earlier studies using ECD analysis failed to identify the modulation of earliest V1 activity.
journal_name
Neuronjournal_title
Neuronauthors
Poghosyan V,Ioannides AAdoi
10.1016/j.neuron.2008.04.013subject
Has Abstractpub_date
2008-06-12 00:00:00pages
802-13issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(08)00339-5journal_volume
58pub_type
杂志文章相关文献
NEURON文献大全abstract::The amplitudes and kinetics of miniature excitatory synaptic currents (MESCs) in mammalian central neurons vary widely. It is unclear whether this variability occurs at each synapse or arises from differences among a heterogeneous population of synapses. Furthermore, it is not known how variability in these currents w...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90073-x
更新日期:1995-07-01 00:00:00
abstract::Neural synchronization plays an important role in information flow in the nervous system under healthy and pathological conditions. In this issue of Neuron, Gittis et al. show that reorganization of striatal microcircuits promotes synchronous activity and may underlie the pathological network oscillations at the root ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2011.08.012
更新日期:2011-09-08 00:00:00
abstract::The tactile somatosensory pathway from whisker to cortex in rodents provides a well-defined system for exploring the link between molecular mechanisms, synaptic circuits, and behavior. The primary somatosensory cortex has an exquisite somatotopic map where each individual whisker is represented in a discrete anatomica...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2007.09.017
更新日期:2007-10-25 00:00:00
abstract::Mice lacking the EphB2 receptor tyrosine kinase display a cell-autonomous, strain-specific circling behavior that is associated with vestibular phenotypes. In mutant embryos, the contralateral inner ear efferent growth cones exhibit inappropriate pathway selection at the midline, while in mutant adults, the endolymph-...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81174-5
更新日期:2000-05-01 00:00:00
abstract::The primary visual cortex has a map of multiple visual parameters whose topographic relations remain poorly understood. A new study (Nauhaus et al., 2016) reveals a nearly geometric map-topography that coexists within a remarkably precise representation of visual space. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.08.001
更新日期:2016-08-17 00:00:00
abstract::To characterize the role of rare complete human knockouts in autism spectrum disorders (ASDs), we identify genes with homozygous or compound heterozygous loss-of-function (LoF) variants (defined as nonsense and essential splice sites) from exome sequencing of 933 cases and 869 controls. We identify a 2-fold increase i...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.12.029
更新日期:2013-01-23 00:00:00
abstract::Forming long-term memory (LTM) often requires repetitive experience spread over time. Studies in Drosophila suggest aversive olfactory LTM is optimal after spaced training, multiple trials of differential odor conditioning with rest intervals. Memory after spaced training is frequently compared to that after the same ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.03.013
更新日期:2020-06-17 00:00:00
abstract::Historically, the rat has been the preferred animal model for behavioral studies. Limitations in genome modification have, however, caused a lag in their use compared to the bevy of available transgenic mice. Here, we have developed several transgenic tools, including viral vectors and transgenic rats, for targeted ge...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.035
更新日期:2019-04-03 00:00:00
abstract::The role of the target cell in neurotrophin-induced modifications of glutamatergic synaptic transmission was examined in cultured hippocampal neurons. Brain-derived neurotrophic factor (BDNF) induced rapid and persistent potentiation of evoked glutamate release when the postsynaptic neuron was glutamatergic, or excita...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80879-x
更新日期:2000-01-01 00:00:00
abstract::Memory decline in aging results from multiple factors that influence both executive function and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems are preferentially vulnerable to white matter change, atrophy, and certain forms of neurotransmitter depletion. Frontal-striatal change ma...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2004.09.006
更新日期:2004-09-30 00:00:00
abstract::Oxygen (O₂) and carbon dioxide (CO₂) levels vary in different environments and locally fluctuate during respiration and photosynthesis. Recent studies in diverse animals have identified sensory neurons that detect these external variations and direct a variety of behaviors. Detection allows animals to stay within a pr...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2010.12.018
更新日期:2011-01-27 00:00:00
abstract::For the past 60 years, the central nervous system has been considered immunologically privileged. Yet results from diverse fields show clear and convincing evidence of bidirectional communication between the nervous and immune systems. ...
journal_title:Neuron
pub_type:
doi:10.1016/j.neuron.2009.09.038
更新日期:2009-10-15 00:00:00
abstract::Our perception of fine visual detail relies on small receptive fields at early stages of visual processing. However, small receptive fields tend to confound the orientation and velocity of moving edges, leading to ambiguous or inaccurate motion measurements (the aperture problem). Thus, it is often assumed that neuron...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00439-2
更新日期:2003-08-14 00:00:00
abstract::Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.09.006
更新日期:2008-09-25 00:00:00
abstract::The formation, function, and plasticity of synapses require dynamic changes in synaptic receptor composition. Here, we identify the sorting receptor SorCS1 as a key regulator of synaptic receptor trafficking. Four independent proteomic analyses identify the synaptic adhesion molecule neurexin and the AMPA glutamate re...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.08.007
更新日期:2015-08-19 00:00:00
abstract::Grid cells in medial entorhinal cortex (MEC) can be modeled using oscillatory interference or attractor dynamic mechanisms that perform path integration, a computation requiring information about running direction and speed. The two classes of computational models often use either an oscillatory frequency or a firing ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.06.027
更新日期:2016-08-03 00:00:00
abstract::The relative timing of presynaptic and postsynaptic spikes plays a critical role in activity-induced synaptic modification. Here we examined whether plasticity of orientation selectivity in the visual cortex depends on stimulus timing. Repetitive pairing of visual stimuli at two orientations induced a shift in orienta...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00460-3
更新日期:2001-10-25 00:00:00
abstract::Presynaptic CaV2 channels are essential for Ca2+-triggered exocytosis. In addition, there are two competing models for their roles in synapse structure. First, Ca2+ channels or Ca2+ entry may control synapse assembly. Second, active zone proteins may scaffold CaV2s to presynaptic release sites, and synapse structure i...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.05.032
更新日期:2020-08-19 00:00:00
abstract::A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.09.027
更新日期:2008-10-09 00:00:00
abstract::Information processing by a sensory system is reflected in the changes in stimulus representation along its successive processing stages. We measured information content and stimulus-induced redundancy in the neural responses to a set of natural sounds in three successive stations of the auditory pathway-inferior coll...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.06.030
更新日期:2006-08-03 00:00:00
abstract::Forty years ago, von Békésy demonstrated that the spatial source of an odorant is determined by comparing input across nostrils, but it is unknown how this comparison is effected in the brain. To address this, we delivered odorants to the left or right of the nose, and contrasted olfactory left versus right localizati...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.06.028
更新日期:2005-08-18 00:00:00
abstract::Several molecules involved in the development of the nervous system have specific binding sites for the glycosaminoglycan (GAG) side chains of proteoglycans. Exogenous GAGs should bind to these sites, competitively inhibit interactions with proteoglycans, and perturb development. GAGs added to the culture medium pertu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90091-q
更新日期:1992-04-01 00:00:00
abstract::Telling time and anticipating when external events will happen is among the most important tasks the brain performs. Yet the neural mechanisms underlying timing remain elusive. One theory proposes that timing is a general and intrinsic computation of cortical circuits. We tested this hypothesis using electrical and op...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.05.042
更新日期:2016-07-20 00:00:00
abstract::During synaptic development, proteins aggregate at specialized pre- and postsynaptic structures. Mechanisms that mediate protein clustering at these sites remain unknown. To investigate this process, we analyzed synaptic targeting of a postsynaptic density protein, PSD-95, by expressing green fluorescent protein- (GFP...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80705-9
更新日期:1999-03-01 00:00:00
abstract::We determined the cellular substrate for male courtship behavior by quasinatural and artificial stimulation of brain neurons. Activation of fruitless (fru)-expressing neurons via stimulation of thermosensitive dTrpA1 channels induced an entire series of courtship acts in male Drosophila placed alone without any courti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.12.017
更新日期:2011-02-10 00:00:00
abstract::The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in inform...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.02.047
更新日期:2017-05-03 00:00:00
abstract::The stabilization of learned information into long-term memories requires new gene expression. CREB binding protein (CBP) is a coactivator of transcription that can be independently regulated in neurons. CBP functions both as a platform for recruiting other required components of the transcriptional machinery and as a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.06.002
更新日期:2004-06-24 00:00:00
abstract::Insulin-like growth factor I (IGF-I) is a potent regulator of oligodendrocyte development and myelination in vitro, but its effect on myelination in vivo has never been tested directly. Therefore, we examined brain growth and myelination in a transgenic mouse line that overexpresses IGF-I. By postnatal day 55, when br...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90173-o
更新日期:1993-04-01 00:00:00
abstract::In situ hybridization histochemistry reveals localized expression of the nicotinic acetylcholine receptor (nAChR) alpha 2 subunit mRNA restricted to the lateral spiriform nucleus (SpL) of the chick diencephalon. The alpha 2 nAChR transcripts are not detected in immature SpL neurons at 4.5-5 days of embryonic developme...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90032-b
更新日期:1990-07-01 00:00:00
abstract::In this issue of Neuron, Viader et al. (2013) report on the production of toxic lipids by Schwann cells deficient in mitochondrial respiration, which are capable of destroying neighboring axons. This may have implications for understanding the neurobiology and treatment of mitochondrial neuropathies. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2013.02.016
更新日期:2013-03-06 00:00:00