Abstract:
:The formation, function, and plasticity of synapses require dynamic changes in synaptic receptor composition. Here, we identify the sorting receptor SorCS1 as a key regulator of synaptic receptor trafficking. Four independent proteomic analyses identify the synaptic adhesion molecule neurexin and the AMPA glutamate receptor (AMPAR) as major proteins sorted by SorCS1. SorCS1 localizes to early and recycling endosomes and regulates neurexin and AMPAR surface trafficking. Surface proteome analysis of SorCS1-deficient neurons shows decreased surface levels of these, and additional, receptors. Quantitative in vivo analysis of SorCS1-knockout synaptic proteomes identifies SorCS1 as a global trafficking regulator and reveals decreased levels of receptors regulating adhesion and neurotransmission, including neurexins and AMPARs. Consequently, glutamatergic transmission at SorCS1-deficient synapses is reduced due to impaired AMPAR surface expression. SORCS1 mutations have been associated with autism and Alzheimer disease, suggesting that perturbed receptor trafficking contributes to synaptic-composition and -function defects underlying synaptopathies.
journal_name
Neuronjournal_title
Neuronauthors
Savas JN,Ribeiro LF,Wierda KD,Wright R,DeNardo-Wilke LA,Rice HC,Chamma I,Wang YZ,Zemla R,Lavallée-Adam M,Vennekens KM,O'Sullivan ML,Antonios JK,Hall EA,Thoumine O,Attie AD,Yates JR 3rd,Ghosh A,de Wit Jdoi
10.1016/j.neuron.2015.08.007subject
Has Abstractpub_date
2015-08-19 00:00:00pages
764-80issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00682-0journal_volume
87pub_type
杂志文章相关文献
NEURON文献大全abstract::Nervous system injury and disease have broad effects on the functional connectivity of the nervous system, but how injury signals are spread across neural circuits remains unclear. We explored how axotomy changes the physiology of severed axons and adjacent uninjured "bystander" neurons in a simple in vivo nerve prepa...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.11.012
更新日期:2020-12-02 00:00:00
abstract::A neural network can sustain and switch between different activity patterns to execute multiple behaviors. By monitoring the decision making for directional locomotion through motor circuit calcium imaging in behaving Caenorhabditis elegans (C. elegans), we reveal that C. elegans determines the directionality of movem...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.09.005
更新日期:2011-11-17 00:00:00
abstract::We show here that antisense MAP2 oligonucleotides inhibit neurite outgrowth in cultured cerebellar macroneurons. Unlike control neurons, which first extend a lamellipodial veil followed by a consolidation phase during which the cells extend minor neurites, MAP2-suppressed cells persist with lamellipodia and later beco...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90025-9
更新日期:1992-10-01 00:00:00
abstract::Several cDNAs encoding an isoform of the alpha 1 subunit of the voltage-dependent calcium channel were isolated from rat brain cDNA libraries. The complete nucleotide sequence of 6975 bp encodes a protein of 1634 amino acids, which corresponds to an Mr of 186,968. The protein exhibits 71% and 76% homology to skeletal ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90072-8
更新日期:1991-07-01 00:00:00
abstract::The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV cargo occurs at the plasma membrane. Activity-dependent bulk endocytosis (ADBE) ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.10.043
更新日期:2015-12-02 00:00:00
abstract::During development of the mammalian nervous system, neural stem cells generate neurons first and glia second, thereby allowing the initial establishment of neural circuitry, and subsequent matching of glial numbers and position to that circuitry. Here, we have reviewed work addressing the mechanisms underlying this ti...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2007.04.019
更新日期:2007-05-03 00:00:00
abstract::Sequential neural activity patterns are as ubiquitous as the outputs they drive, which include motor gestures and sequential cognitive processes. Neural sequences are long, compared to the activation durations of participating neurons, and sequence coding is sparse. Numerous studies demonstrate that spike-time-depende...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.02.003
更新日期:2010-02-25 00:00:00
abstract::Neural crest cells of vertebrate embryos produce neurons, glia, pigment cells, and connective tissue in vivo and in vitro. To test the developmental potential of apparently undifferentiated crest cells, we have used the monoclonal antibody A2B5, which recognizes a cell surface glycolipid characteristic of neurons, to ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90106-7
更新日期:1988-09-01 00:00:00
abstract::Pheromonal activation of the vomeronasal organ (VNO) elicits genetically preprogrammed behaviors and physiological changes in mammals. We have identified a novel gene family encoding over one hundred VNO specific receptors, the V3Rs. V3R sequences are highly similar to each other and appear distantly related to the pu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00157-4
更新日期:2000-12-01 00:00:00
abstract::Spinal cord axons display a rostrocaudal, positional bias in their innervation of sympathetic ganglia and intercostal skeletal muscles. In an effort to examine the molecular basis of this positional specificity, we used the cyclophosphamide immunosuppression method to produce monoclonal antibodies that bind preferenti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90081-p
更新日期:1990-10-01 00:00:00
abstract::Astrocytes metabolically interact with neighboring neurons by providing multiple substances to neurons. How astrocytes regulate neural functions via altering the neuronal metabolic state remains elusive. Here, we demonstrate that astrocytic ApoE vectors a variety of microRNAs (miRNAs), and these miRNAs specifically si...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2021.01.005
更新日期:2021-01-21 00:00:00
abstract::Experience is a powerful sculptor of developing neural connections. In the primary visual cortex (V1), cortical connections are particularly susceptible to the effects of sensory manipulation during a postnatal critical period. At the molecular level, this activity-dependent plasticity requires the transformation of s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00966-2
更新日期:2002-10-24 00:00:00
abstract::Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilateral...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.08.015
更新日期:2013-11-20 00:00:00
abstract::Since the early days of research into language and the brain, word meaning was assumed to be processed in specific brain regions, which most modern neuroscientists localize to the left temporal lobe. Here we use event-related fMRI to show that action words referring to face, arm, or leg actions (e.g., to lick, pick, o...
journal_title:Neuron
pub_type: 临床试验,杂志文章
doi:10.1016/s0896-6273(03)00838-9
更新日期:2004-01-22 00:00:00
abstract::As different classes of sensory neurons project into the CNS, their axons segregate and establish distinct trajectories and target zones. One striking instance of axonal segregation is the projection of sensory neurons into the spinal cord, where proprioceptive axons avoid the superficial dorsal horn-the target zone o...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.10.032
更新日期:2006-12-07 00:00:00
abstract::We measured brain activity during mental rotation and object recognition with objects rotated around three different axes. Activity in the superior parietal lobe (SPL) increased proportionally to viewpoint disparity during mental rotation, but not during object recognition. In contrast, the fusiform gyrus was preferen...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00622-0
更新日期:2002-03-28 00:00:00
abstract::Convergent evidence suggests that corticostriatal interactions act as a gate to select the input to working memory (WM). However, not all information in WM is relevant for behavior simultaneously. For this reason, a second "output gate" might advantageously govern which contents of WM influence behavior. Here, we test...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.01.002
更新日期:2014-02-19 00:00:00
abstract::The serotonin system powerfully modulates physiology and behavior in health and disease, yet the circuit mechanisms underlying serotonin neuron activity are poorly understood. The major source of forebrain serotonergic innervation is from the dorsal raphe nucleus (DR), which contains both serotonin and GABA neurons. U...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.06.024
更新日期:2014-08-06 00:00:00
abstract::The carboxyl terminus of presenilin 1 and 2 (PS1 and PS2) binds to the neuron-specific cell adhesion molecule telencephalin (TLN) in the brain. PS1 deficiency results in the abnormal accumulation of TLN in a yet unidentified intracellular compartment. The first transmembrane domain and carboxyl terminus of PS1 form a ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00512-8
更新日期:2001-11-20 00:00:00
abstract::Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood. We show here that Notch and abl mutations interact synergistically to produce synthetic lethality and defects in axon extension. Surprisingly, we cannot...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81007-7
更新日期:1998-04-01 00:00:00
abstract::Inhibitors in myelin play a major role in preventing spontaneous axonal regeneration after CNS injury. Elevation of cAMP overcomes this inhibition, in a transcription-dependent manner, through the upregulation of Arginase I (Arg I) and increased synthesis of polyamines. Here, we show that the cAMP effect requires acti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.10.030
更新日期:2004-11-18 00:00:00
abstract::Social environment modulates learning through unknown mechanisms. Here, we report that a pheromone mixture that signals overcrowding inhibits C. elegans from learning to avoid pathogenic bacteria. We find that learning depends on the balanced signaling of two insulin-like peptides (ILPs), INS-16 and INS-4, which act r...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.09.006
更新日期:2019-12-18 00:00:00
abstract::Sustained rate-coded signals encode many types of sensory modalities. Some sensory synapses possess specialized ribbon structures, which tether vesicles, to enable high-frequency signaling. However, central synapses lack these structures, yet some can maintain signaling over a wide bandwidth. To analyze the underlying...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.10.026
更新日期:2010-11-18 00:00:00
abstract::Forming long-term memory (LTM) often requires repetitive experience spread over time. Studies in Drosophila suggest aversive olfactory LTM is optimal after spaced training, multiple trials of differential odor conditioning with rest intervals. Memory after spaced training is frequently compared to that after the same ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.03.013
更新日期:2020-06-17 00:00:00
abstract::Successful visual navigation requires a sense of the geometry of the local environment. How do our brains extract this information from retinal images? Here we visually presented scenes with all possible combinations of five scene-bounding elements (left, right, and back walls; ceiling; floor) to human subjects during...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.04.014
更新日期:2019-07-03 00:00:00
abstract::Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently described neurodegenerative disorder of older adult carriers of premutation alleles (60-200 CGG repeats) in the fragile X mental retardation gene (FMR1). It has been proposed that FXTAS is an RNA-mediated neurodegenerative disease caused by the titratio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.07.021
更新日期:2007-08-16 00:00:00
abstract::Experimental evidence shows that the inability to attribute mental states, such as desires and beliefs, to self and others (mentalizing) explains the social and communication impairments of individuals with autism. Brain imaging studies in normal volunteers highlight a circumscribed network that is active during menta...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(01)00552-9
更新日期:2001-12-20 00:00:00
abstract::Historical milestones in neuroscience have come in diverse forms, ranging from the resolution of specific biological mysteries via creative experimentation to broad technological advances allowing neuroscientists to ask new kinds of questions. The continuous development of tools is driven with a special necessity by t...
journal_title:Neuron
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neuron.2013.10.032
更新日期:2013-10-30 00:00:00
abstract::The brain basis of language, music, and emotion can be studied from the perspective of the psychological and cognitive sciences. Does this approach link to concerns of the humanities meaningfully? We outline prospects of developing a genuine neurohumanities research program. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.10.021
更新日期:2020-11-25 00:00:00
abstract::In this issue of Neuron, Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3' UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.04.019
更新日期:2019-05-08 00:00:00