Differential expression of the neuronal acetylcholine receptor alpha 2 subunit gene during chick brain development.

abstract：:The calcium-activated small conductance potassium channel SK3 plays an essential role in the regulation of dopamine neuron activity patterns. Here we demonstrate that expression of a human disease-related SK3 mutation (hSK3Δ) in dopamine neurons of mice disrupts the balance between tonic and phasic dopamine neuron act...

journal_title：Neuron

authors： Soden ME,Jones GL,Sanford CA,Chung AS,Güler AD,Chavkin C,Luján R,Zweifel LS

更新日期：2013-11-20 00:00:00

abstract：:Brain circuits endow behavioral flexibility. Here, we study circuits encoding flexible chemotaxis in C. elegans, where the animal navigates up or down NaCl gradients (positive or negative chemotaxis) to reach the salt concentration of previous growth (the set point). The ASER sensory neuron mediates positive and negat...

journal_title：Neuron

authors： Luo L,Wen Q,Ren J,Hendricks M,Gershow M,Qin Y,Greenwood J,Soucy ER,Klein M,Smith-Parker HK,Calvo AC,Colón-Ramos DA,Samuel AD,Zhang Y

更新日期：2014-06-04 00:00:00

abstract：:We present evidence that synapse retraction occurs during normal synaptic growth at the Drosophila neuromuscular junction (NMJ). An RNAi-based screen to identify the molecular mechanisms that regulate synapse retraction identified Arp-1/centractin, a subunit of the dynactin complex. Arp-1 dsRNA enhances synapse retrac...

journal_title：Neuron

authors： Eaton BA,Fetter RD,Davis GW

更新日期：2002-05-30 00:00:00

abstract：:Currents mediated by a glutamate transporter cloned from human motor cortex were measured in Xenopus oocytes. In the absence of glutamate, voltage jumps induced Na(+)-dependent capacitive currents that were blocked by kainate, a competitive transport antagonist. The pre-steady-state currents can be described by an ord...

journal_title：Neuron

authors： Wadiche JI,Arriza JL,Amara SG,Kavanaugh MP

更新日期：1995-05-01 00:00:00

abstract：:We report a role for long-distance retrograde neurotrophin signaling in the establishment of synapses in the sympathetic nervous system. Target-derived NGF is both necessary and sufficient for formation of postsynaptic specializations on dendrites of sympathetic neurons. This, in turn, is a prerequisite for formation ...

journal_title：Neuron

authors： Sharma N,Deppmann CD,Harrington AW,St Hillaire C,Chen ZY,Lee FS,Ginty DD

更新日期：2010-08-12 00:00:00

abstract：:Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental question in addiction biology is why exogenous opiate drugs have a high liability for inducing tolerance and addiction while native ligands do not. Studies indicate that highly addictive opiate d...

journal_title：Neuron

authors： Whistler JL,Chuang HH,Chu P,Jan LY,von Zastrow M

更新日期：1999-08-01 00:00:00

abstract：:Quaternary ammonium (QA) compounds inhibit K+ conductance by entering and occluding the open pore of voltage-activated K+ channels. We characterized the effects of a series of alkyl-triethylammonium blockers on the Shaker K+ channel and tested them on a series of site-directed mutants of the channel protein in order t...

journal_title：Neuron

authors： Choi KL,Mossman C,Aubé J,Yellen G

更新日期：1993-03-01 00:00:00

abstract：:mRNAs for AMPA- and kainate-preferring glutamate receptor subunits are expressed abundantly in the CNS, yet functional studies of neurons and glia from brain suggest selective expression of AMPA receptors. We now show that glial cells of the O-2A lineage express rapidly desensitizing responses to kainate, mRNAs for Gl...

journal_title：Neuron

authors： Patneau DK,Wright PW,Winters C,Mayer ML,Gallo V

更新日期：1994-02-01 00:00:00

abstract：:Elucidating the molecular mechanisms underlying quantitative neurocognitive phenotypes will further our understanding of the brain's structural and functional architecture and advance the diagnosis and treatment of the psychiatric disorders that these traits underlie. Although many neurocognitive traits are highly her...

journal_title：Neuron

authors： Congdon E,Poldrack RA,Freimer NB

更新日期：2010-10-21 00:00:00

abstract：:The Drosophila circadian oscillator consists of interlocked period (per)/timeless (tim) and Clock (Clk) transcriptional/translational feedback loops. Within these feedback loops, CLK and CYCLE (CYC) activate per and tim transcription at the same time as they repress Clk transcription, thus controlling the opposite cyc...

journal_title：Neuron

authors： Glossop NR,Houl JH,Zheng H,Ng FS,Dudek SM,Hardin PE

更新日期：2003-01-23 00:00:00

abstract：:Spike timing-dependent synaptic plasticity (STDP) serves as a key cellular correlate of associative learning, which is facilitated by elevated attentional and emotional states involving activation of adrenergic signaling. At cellular levels, adrenergic signaling increases dendrite excitability, but the underlying mech...

journal_title：Neuron

authors： Liu Y,Cui L,Schwarz MK,Dong Y,Schlüter OM

更新日期：2017-01-18 00:00:00

abstract：:In neurons, posttranslational modification by palmitate regulates the trafficking and function of signaling molecules, neurotransmitter receptors, and associated synaptic scaffolding proteins. However, the enzymatic machinery involved in protein palmitoylation has remained elusive. Here, using biochemical assays, we s...

journal_title：Neuron

authors： Huang K,Yanai A,Kang R,Arstikaitis P,Singaraja RR,Metzler M,Mullard A,Haigh B,Gauthier-Campbell C,Gutekunst CA,Hayden MR,El-Husseini A

更新日期：2004-12-16 00:00:00

abstract：:The entire length of myelinated axons is organized into a series of polarized domains that center around nodes of Ranvier. These domains, which are crucial for normal saltatory conduction, consist of distinct multiprotein complexes of cell adhesion molecules, ion channels, and scaffolding molecules; they also differ i...

journal_title：Neuron

authors： Salzer JL

更新日期：2003-10-09 00:00:00

abstract：:The Purkinje cell degeneration (pcd) mouse is a recessive model of neurodegeneration, involving cerebellum and retina. Purkinje cell death in pcd is dramatic, as >99% of Purkinje neurons are lost in 3 weeks. Loss of function of Nna1 causes pcd, and Nna1 is a highly conserved zinc carboxypeptidase. To determine the bas...

journal_title：Neuron

authors： Chakrabarti L,Zahra R,Jackson SM,Kazemi-Esfarjani P,Sopher BL,Mason AG,Toneff T,Ryu S,Shaffer S,Kansy JW,Eng J,Merrihew G,MacCoss MJ,Murphy A,Goodlett DR,Hook V,Bennett CL,Pallanck LJ,La Spada AR

更新日期：2010-06-24 00:00:00

abstract：:The level of electrotonic coupling in the inferior olive is extremely high, but its functional role in cerebellar motor control remains elusive. Here, we subjected mice that lack olivary coupling to paradigms that require learning-dependent timing. Cx36-deficient mice showed impaired timing of both locomotion and eye-...

journal_title：Neuron

authors： Van Der Giessen RS,Koekkoek SK,van Dorp S,De Gruijl JR,Cupido A,Khosrovani S,Dortland B,Wellershaus K,Degen J,Deuchars J,Fuchs EC,Monyer H,Willecke K,De Jeu MT,De Zeeuw CI

更新日期：2008-05-22 00:00:00

abstract：:A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development. Here, we demonstrate that Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and...

journal_title：Neuron

authors： D'Arcangelo G,Homayouni R,Keshvara L,Rice DS,Sheldon M,Curran T

更新日期：1999-10-01 00:00:00

abstract：:Activation of kainate receptors causes Co2+ influx into neurons, type-2 astrocytes, and O-2A progenitor cells. Agonist-activated Co2+ uptake can be performed using cultured cells or fresh tissue slices. Based on the pattern of response to kainate, glutamate, and quisqualate, three functionally different kainate-activa...

journal_title：Neuron

authors： Pruss RM,Akeson RL,Racke MM,Wilburn JL

更新日期：1991-09-01 00:00:00

abstract：:An impressive body of research over the past 30 years has implicated the human cerebellum in a broad range of functions, including motor control, perception, language, working memory, cognitive control, and social cognition. The relatively uniform anatomy and physiology of the cerebellar cortex has given rise to the i...

journal_title：Neuron

authors： Diedrichsen J,King M,Hernandez-Castillo C,Sereno M,Ivry RB

更新日期：2019-06-05 00:00:00

abstract：:We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...

journal_title：Neuron

authors： Maconochie DJ,Zempel JM,Steinbach JH

更新日期：1994-01-01 00:00:00

abstract：:The controversy about whether dopamine contributes to cell loss in Parkinson's disease takes a new turn as Mosharov et al. in this issue of Neuron demonstrate that Ca2+ influx through L-type channels elevates dopamine synthesis to potentially toxic levels in vulnerable ventral mesencephalon neurons. ...

journal_title：Neuron

authors： Surmeier DJ

更新日期：2009-04-30 00:00:00

abstract：:Two rabbit polyclonal antibodies generated against different portions of the amyloid precursor protein were used to localize this protein in normal rat brain. Light and electron microscopic immunohistochemical localizations demonstrate that the protein is widely distributed throughout the neuraxis, with the highest co...

journal_title：Neuron

authors： Card JP,Meade RP,Davis LG

更新日期：1988-11-01 00:00:00

abstract：:About two-thirds of the antibodies to the nicotinic acetylcholine (ACh) receptor in patients with the autoimmune disease myasthenia gravis bind to the main immunogenic region (MIR). This is small, well-defined region on each of the two alpha subunits, containing residues 67-76 (alpha 67-76). By determining the structu...

journal_title：Neuron

authors： Beroukhim R,Unwin N

更新日期：1995-08-01 00:00:00

abstract：:The visual cortex represents stimuli through the activity of neuronal populations. We measured the evolution of this activity in space and time by imaging voltage-sensitive dyes in cat area V1. Contrast-reversing stimuli elicit responses that oscillate at twice the stimulus frequency, indicating that signals originate...

journal_title：Neuron

authors： Benucci A,Frazor RA,Carandini M

更新日期：2007-07-05 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implicated in the biochemical ...

journal_title：Neuron

authors： Giasson BI,Lee VM

更新日期：2001-09-27 00:00:00

abstract：:Amphetamine (AMPH) releases monoamines, transiently stimulates locomotion, and inhibits feeding. Using a genetic approach, we show that mice lacking dopamine (DA-deficient, or DD, mice) are resistant to the hypophagic effects of a moderate dose of AMPH (2 microg/g) but manifest normal AMPH-induced hypophagia after res...

journal_title：Neuron

authors： Cannon CM,Abdallah L,Tecott LH,During MJ,Palmiter RD

更新日期：2004-10-28 00:00:00

abstract：:We have investigated ubiquitinated paired helical filaments, which produce a proteinaceous smear in SDS-polyacrylamide gel electrophoresis and immunoblotting. The smear consisted largely of the carboxy-terminal portion of tau and ubiquitin. The ubiquitin-targeted protein was identified as tau in paired helical filamen...

journal_title：Neuron

authors： Morishima-Kawashima M,Hasegawa M,Takio K,Suzuki M,Titani K,Ihara Y

更新日期：1993-06-01 00:00:00

abstract：:We have used immunogold electron microscopy to study the organization of the acetylcholine receptor, 43 kd protein, voltage-sensitive Na+ channel, and ankyrin in the postsynaptic membrane of the rat neuromuscular junction. The acetylcholine receptor and the 43 kd protein are concentrated at the crests of the postsynap...

journal_title：Neuron

authors： Flucher BE,Daniels MP

更新日期：1989-08-01 00:00:00

abstract：:To survive, humans must estimate their own ability and the abilities of others. We found that, although people estimated their abilities on the basis of their own performance in a rational manner, their estimates of themselves were partly merged with the performance of others. Reciprocally, their ability estimates for...

journal_title：Neuron

authors： Wittmann MK,Kolling N,Faber NS,Scholl J,Nelissen N,Rushworth MF

更新日期：2016-07-20 00:00:00

abstract：:Primates can learn to recognize a virtually limitless number of visual objects. A candidate neural substrate for this adult plasticity is the inferior temporal cortex (ITC). Using a large stimulus set, we explored the impact that long-term experience has on the response properties of two classes of neurons in ITC: bro...

journal_title：Neuron

authors： Woloszyn L,Sheinberg DL

更新日期：2012-04-12 00:00:00

abstract：:Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGluR-dependent LTD. The increase in Arc/Arg3.1 translation requires e...

journal_title：Neuron

authors： Park S,Park JM,Kim S,Kim JA,Shepherd JD,Smith-Hicks CL,Chowdhury S,Kaufmann W,Kuhl D,Ryazanov AG,Huganir RL,Linden DJ,Worley PF

更新日期：2008-07-10 00:00:00