A lethal convergence of dopamine and calcium.

abstract：:Neuromodulators regulate circuits throughout the nervous system, and revealing the cell types and stimulus conditions controlling their release is vital to understanding their function. The effects of the neuromodulator nitric oxide (NO) have been studied in many circuits, including in the vertebrate retina, where it ...

journal_title：Neuron

authors： Jacoby J,Nath A,Jessen ZF,Schwartz GW

更新日期：2018-12-05 00:00:00

abstract：:Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ₄₂ are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses. We performed the largest genome-wide association study for cerebrospinal fluid (CSF) tau/ptau levels published to d...

journal_title：Neuron

authors： Cruchaga C,Kauwe JS,Harari O,Jin SC,Cai Y,Karch CM,Benitez BA,Jeng AT,Skorupa T,Carrell D,Bertelsen S,Bailey M,McKean D,Shulman JM,De Jager PL,Chibnik L,Bennett DA,Arnold SE,Harold D,Sims R,Gerrish A,Williams J

更新日期：2013-04-24 00:00:00

abstract：:Although motion-sensitive neurons in macaque middle temporal (MT) area are conventionally characterized using stimuli whose velocity remains constant for 1-3 s, many ecologically relevant stimuli change on a shorter time scale (30-300 ms). We compared neuronal responses to conventional (constant-velocity) and time-var...

journal_title：Neuron

authors： Buracas GT,Zador AM,DeWeese MR,Albright TD

更新日期：1998-05-01 00:00:00

abstract：:People often perceive configurations rather than the elements they comprise, a bias that may emerge because configurations often predict outcomes. But how does the brain learn to associate configurations with outcomes and how does this learning differ from learning about individual elements? We combined behavior, rein...

journal_title：Neuron

authors： Duncan K,Doll BB,Daw ND,Shohamy D

更新日期：2018-05-02 00:00:00

abstract：:Conditioned appetitive and aversive responses (CRs) are thought to result from the activation of specific subsets of valence-coding basolateral amygdala (BLA) neurons. Under this model, the responses of BLA cells to conditioned stimuli (CSs) and the activity that drives CRs are closely related. We tested the strength ...

journal_title：Neuron

authors： Kyriazi P,Headley DB,Pare D

更新日期：2018-09-19 00:00:00

abstract：:How does the noradrenergic nucleus locus coeruleus act on target networks to regulate behavior? In this issue of Neuron, Zerbi et al. (2019) combine functional neuroimaging and pharmacogenetics in mice to tackle that question, uncovering a network action underlying stress. And providing insight for cognition? ...

journal_title：Neuron

authors： Bouret S

更新日期：2019-08-21 00:00:00

abstract：:Trk tyrosine kinases are receptors for members of the neurotrophin family and are crucial for growth and survival of specific populations of neurons. Yet, the functions of neurotrophin-Trk signaling in postnatal development as well as maintenance and plasticity of the adult nervous system are less clear. We report her...

journal_title：Neuron

authors： Chen X,Ye H,Kuruvilla R,Ramanan N,Scangos KW,Zhang C,Johnson NM,England PM,Shokat KM,Ginty DD

更新日期：2005-04-07 00:00:00

abstract：:According to economic theories, preference for one item over others reveals its rank value on a common scale. Previous studies identified brain regions encoding such values. Here we verify that these regions can valuate various categories of objects and further test whether they still express preferences when attentio...

journal_title：Neuron

authors： Lebreton M,Jorge S,Michel V,Thirion B,Pessiglione M

更新日期：2009-11-12 00:00:00

abstract：:Diagnoses of behavioral disorders such as autism spectrum disorder and schizophrenia are based on symptomatic descriptions that have been difficult to connect to mechanism. Although psychiatric genetics provide insight into the genetic underpinning of such disorders, with a majority of cases explained by polygenic fac...

journal_title：Neuron

authors： Krol A,Wimmer RD,Halassa MM,Feng G

更新日期：2018-04-18 00:00:00

abstract：:The forebrain is one of most complex cellular structures known. Two phenomena that enable this complexity are tangential migrations that mix neurons from distinct progenitor fields, and axon guidance across intervening, noninnervated fields. A new paper in Cell by López-Bendito et al. has discovered the convergence of...

journal_title：Neuron

authors： Maroof AM,Anderson SA

更新日期：2006-04-20 00:00:00

abstract：:Ephrin signaling through Eph receptor tyrosine kinases can promote attraction or repulsion of axonal growth cones during development. However, the mechanisms that determine whether Eph signaling promotes attraction or repulsion are not known. We show here that the Rho family GEF Vav2 plays a key role in this process. ...

journal_title：Neuron

authors： Cowan CW,Shao YR,Sahin M,Shamah SM,Lin MZ,Greer PL,Gao S,Griffith EC,Brugge JS,Greenberg ME

更新日期：2005-04-21 00:00:00

abstract：:The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the medial ganglionic eminence, the NKX2-1 transcription factor controls regional id...

journal_title：Neuron

authors： Sandberg M,Flandin P,Silberberg S,Su-Feher L,Price JD,Hu JS,Kim C,Visel A,Nord AS,Rubenstein JLR

更新日期：2016-09-21 00:00:00

abstract：:bHLH and LIM-HD transcription factors were originally thought to act at different stages of neurogenesis: bHLHs as neuronal "inducers" and LIM-HDs as postmitotic subtype determinants. These distinctions are becoming blurred, and a current study by Lee and Pfaff in this issue of Neuron shows that interaction between th...

journal_title：Neuron

authors： Allan DW,Thor S

更新日期：2003-06-05 00:00:00

abstract：:Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose and many neuropsychiatric comorbidities. Uncovering the mechanisms responsible for pain-induced negative affect is critical in addressing these comorbid outcomes...

journal_title：Neuron

authors： Massaly N,Copits BA,Wilson-Poe AR,Hipólito L,Markovic T,Yoon HJ,Liu S,Walicki MC,Bhatti DL,Sirohi S,Klaas A,Walker BM,Neve R,Cahill CM,Shoghi KI,Gereau RW 4th,McCall JG,Al-Hasani R,Bruchas MR,Morón JA

更新日期：2019-05-08 00:00:00

abstract：:Altered microRNA profiles have been implicated in human brain disorders. However, the functional contribution of individual microRNAs to neuronal development and function is largely unknown. Here, we report biological functions for miR-19 in adult neurogenesis. We determined that miR-19 is enriched in neural progenito...

journal_title：Neuron

authors： Han J,Kim HJ,Schafer ST,Paquola A,Clemenson GD,Toda T,Oh J,Pankonin AR,Lee BS,Johnston ST,Sarkar A,Denli AM,Gage FH

更新日期：2016-07-06 00:00:00

abstract：:The decision to engage in one behavior often precludes the selection of others, suggesting cross-inhibition between incompatible behaviors. For example, the likelihood to initiate feeding might be influenced by an animal's commitment to other behaviors. Here, we examine the modulation of feeding behavior in the fruit ...

journal_title：Neuron

authors： Mann K,Gordon MD,Scott K

更新日期：2013-08-21 00:00:00

abstract：:We report that EphB receptors direct unique axonal behaviors required for mapping the dorsal-ventral (D-V) retinal axis along the lateral-medial (L-M) axis of the superior colliculus (SC). EphBs are expressed in a D-V gradient, ephrin-B1 in a L-M gradient in SC, and ephrin-B3 at its midline. EphBs and ephrin-Bs are ex...

journal_title：Neuron

authors： Hindges R,McLaughlin T,Genoud N,Henkemeyer M,O'Leary D

更新日期：2002-08-01 00:00:00

abstract：:Here we define activities of RIM-binding protein (RBP) that are essential for baseline neurotransmission and presynaptic homeostatic plasticity. At baseline, rbp mutants have a ∼10-fold decrease in the apparent Ca(2+) sensitivity of release that we attribute to (1) impaired presynaptic Ca(2+) influx, (2) looser coupli...

journal_title：Neuron

authors： Müller M,Genç Ö,Davis GW

更新日期：2015-03-04 00:00:00

abstract：:In a complex nervous system, neuronal functional diversity is reflected in the wide variety of dendritic arbor shapes. Different neuronal classes are defined by class-specific transcription factor combinatorial codes. We show that the combination of the transcription factors Knot and Cut is particular to Drosophila cl...

journal_title：Neuron

authors： Jinushi-Nakao S,Arvind R,Amikura R,Kinameri E,Liu AW,Moore AW

更新日期：2007-12-20 00:00:00

abstract：:The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in inform...

journal_title：Neuron

authors： Jackman SL,Regehr WG

更新日期：2017-05-03 00:00:00

abstract：:The dynamic interactions between hippocampus and amygdala are critical for emotional memory. Theta synchrony between these structures occurs during fear memory retrieval and may facilitate synaptic plasticity, but the cellular mechanisms are unknown. We report that interneurons of the mouse basal amygdala are activate...

journal_title：Neuron

authors： Bazelot M,Bocchio M,Kasugai Y,Fischer D,Dodson PD,Ferraguti F,Capogna M

更新日期：2015-09-23 00:00:00

abstract：:Formation of the normal mammalian cerebral cortex requires the migration of GABAergic inhibitory interneurons from an extracortical origin, the lateral ganglionic eminence (LGE). Mechanisms guiding the migratory direction of these neurons, or other neurons in the neocortex, are not well understood. We have used an exp...

journal_title：Neuron

authors： Zhu Y,Li H,Zhou L,Wu JY,Rao Y

更新日期：1999-07-01 00:00:00

abstract：:In the developing nervous system, neurons are generated at sites distant from their ultimate location. In the vertebrate CNS, neurons utilize distinct migration strategies to reach their ultimate residence. This review discusses the contribution of tangential migration to the architectural development of the cerebral ...

journal_title：Neuron

authors： Maricich SM,Gilmore EC,Herrup K

更新日期：2001-08-02 00:00:00

abstract：:Several cDNAs encoding an isoform of the alpha 1 subunit of the voltage-dependent calcium channel were isolated from rat brain cDNA libraries. The complete nucleotide sequence of 6975 bp encodes a protein of 1634 amino acids, which corresponds to an Mr of 186,968. The protein exhibits 71% and 76% homology to skeletal ...

journal_title：Neuron

authors： Hui A,Ellinor PT,Krizanova O,Wang JJ,Diebold RJ,Schwartz A

更新日期：1991-07-01 00:00:00

abstract：:We show here that antisense MAP2 oligonucleotides inhibit neurite outgrowth in cultured cerebellar macroneurons. Unlike control neurons, which first extend a lamellipodial veil followed by a consolidation phase during which the cells extend minor neurites, MAP2-suppressed cells persist with lamellipodia and later beco...

journal_title：Neuron

authors： Caceres A,Mautino J,Kosik KS

更新日期：1992-10-01 00:00:00

abstract：:Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis. Inhibiting polyamine synthesis blocks the cAMP effect on regeneration. Eithe...

journal_title：Neuron

authors： Cai D,Deng K,Mellado W,Lee J,Ratan RR,Filbin MT

更新日期：2002-08-15 00:00:00

abstract：:Quaternary ammonium (QA) compounds inhibit K+ conductance by entering and occluding the open pore of voltage-activated K+ channels. We characterized the effects of a series of alkyl-triethylammonium blockers on the Shaker K+ channel and tested them on a series of site-directed mutants of the channel protein in order t...

journal_title：Neuron

authors： Choi KL,Mossman C,Aubé J,Yellen G

更新日期：1993-03-01 00:00:00

abstract：:Mammals are able to navigate to hidden goal locations by direct routes that may traverse previously unvisited terrain. Empirical evidence suggests that this "vector navigation" relies on an internal representation of space provided by the hippocampal formation. The periodic spatial firing patterns of grid cells in the...

journal_title：Neuron

authors： Bush D,Barry C,Manson D,Burgess N

更新日期：2015-08-05 00:00:00

abstract：:Retinal specializations such as cone-photoreceptor opsin-expression gradients, as found in several vertebrate species, are intuitively considered detrimental to color vision. In mice, the majority of cones coexpress both "blue" and "green" opsin. The coexpression ratio changes along the dorsoventral axis, resulting in...

journal_title：Neuron

authors： Chang L,Breuninger T,Euler T

更新日期：2013-02-06 00:00:00

abstract：:Neurons that release hypocretin/orexin modulate sleep, arousal, and energy homeostasis; the absence of hypocretin results in narcolepsy. Here we present data on the physiological characteristics of these cells, identified with GFP in transgenic mouse brain slices. Hypocretin-1 and -2 depolarized hypocretin neurons by ...

journal_title：Neuron

authors： Li Y,Gao XB,Sakurai T,van den Pol AN

更新日期：2002-12-19 00:00:00