Abstract：
:In a complex nervous system, neuronal functional diversity is reflected in the wide variety of dendritic arbor shapes. Different neuronal classes are defined by class-specific transcription factor combinatorial codes. We show that the combination of the transcription factors Knot and Cut is particular to Drosophila class IV dendritic arborization (da) neurons. Knot and Cut control different aspects of the dendrite cytoskeleton, promoting microtubule- and actin-based dendritic arbors, respectively. Knot delineates class IV arbor morphology by simultaneously synergizing with Cut to promote complexity and repressing Cut-mediated promotion of dendritic filopodia/spikes. Knot increases dendritic arbor outgrowth through promoting the expression of Spastin, a microtubule-severing protein disrupted in autosomal dominant hereditary spastic paraplegia (AD-HSP). Knot and Cut may modulate cellular mechanisms that are conserved between Drosophila and vertebrates. Hence, this study gives significant general insight into how multiple transcription factors combine to control class-specific dendritic arbor morphology through controlling different aspects of the cytoskeleton.
journal_name
Neuronjournal_title
Neuronauthors
Jinushi-Nakao S,Arvind R,Amikura R,Kinameri E,Liu AW,Moore AWdoi
10.1016/j.neuron.2007.10.031subject
Has Abstractpub_date
2007-12-20 00:00:00pages
963-78issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(07)00827-6journal_volume
56pub_type
杂志文章相关文献
NEURON文献大全abstract：:Despite the best available medical treatments, many patients continue to be disabled by neurologic and psychiatric disorders, resulting in a large unmet need. Advances in imaging and neurophysiology over the last two decades have led to a reinterpretation of some neurologic and psychiatric conditions as primarily diso...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2013.01.020
更新日期：2013-02-06 00:00:00
abstract：:Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.02.018
更新日期：2018-03-07 00:00:00
abstract：:Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our find...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.01.046
更新日期：2016-03-16 00:00:00
abstract：:Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.04.002
更新日期：2020-07-08 00:00:00
abstract：:Neuroscience is an exciting and vibrant field, but building an academic career is not always easy. What are critical success indicators? Which tools help talented young neuroscientists conquer the challenges? In this NeuroView, we discuss instruments and steps that can help people progress through the ranks. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.04.002
更新日期：2015-05-06 00:00:00
abstract：:The anterior insular cortex (AIC) and its unique spindle-shaped von Economo neuron (VEN) emerged within the last decade as having a potentially major role in self-awareness and social cognition in humans. Invasive examination of the VEN has been precluded so far by the assumption that this neuron occurs among primates...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.03.003
更新日期：2012-05-10 00:00:00
abstract：:Spike timing-dependent synaptic plasticity (STDP) serves as a key cellular correlate of associative learning, which is facilitated by elevated attentional and emotional states involving activation of adrenergic signaling. At cellular levels, adrenergic signaling increases dendrite excitability, but the underlying mech...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.12.039
更新日期：2017-01-18 00:00:00
abstract：:Building on Canada's strong traditions in neuroscience and ethics, neuroethics provides a backbone for the evolving Canadian Brain Research Strategy (CBRS) that, from the outset, incorporates ethically responsible discoveries in brain science into clinical, societal, educational, and commercial innovation. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.12.021
更新日期：2019-02-06 00:00:00
abstract：:A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the song control circuit is altered during this critical period. The RNA encodes a soluble presynaptic protein that forms a predic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90040-3
更新日期：1995-08-01 00:00:00
abstract：:We measured brain activity during mental rotation and object recognition with objects rotated around three different axes. Activity in the superior parietal lobe (SPL) increased proportionally to viewpoint disparity during mental rotation, but not during object recognition. In contrast, the fusiform gyrus was preferen...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00622-0
更新日期：2002-03-28 00:00:00
abstract：:Perceptual inference is biased by foreknowledge about what is probable or possible. How prior expectations are neurally represented during visual perception, however, remains unknown. We used functional magnetic resonance imaging to measure brain activity in humans judging simple visual stimuli. Perceptual decisions w...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.05.021
更新日期：2008-07-31 00:00:00
abstract：:The apical tuft of layer 5 pyramidal neurons is innervated by a large number of inhibitory inputs with unknown functions. Here, we studied the functional consequences and underlying molecular mechanisms of apical inhibition on dendritic spike activity. Extracellular stimulation of layer 1, during blockade of glutamate...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.04.019
更新日期：2006-05-18 00:00:00
abstract：:Memory enables flexible use of past experience to inform new behaviors. Although leading theories hypothesize that this fundamental flexibility results from the formation of integrated memory networks relating multiple experiences, the neural mechanisms that support memory integration are not well understood. Here, we...
journal_title：Neuron
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuron.2012.05.010
更新日期：2012-07-12 00:00:00
abstract：:In this perspective I tell the story (albeit a clearly abridged version) of how our knowledge of ion conduction through ion channels has evolved from a purely electrical concept to a structural dynamics view of ions interacting with a membrane protein. Our progress in this field has shown steady growth over the years ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.10.035
更新日期：2008-11-06 00:00:00
abstract：:The panoply of cognitive, affective, motivational, and social functions that underpin everyday human experience requires precisely choreographed patterns of interaction between networked brain regions. Perhaps not surprisingly, diverse forms of psychopathology are characterized by breakdowns in these interregional rel...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2012.06.002
更新日期：2012-06-21 00:00:00
abstract：:Neuroscientific findings are rarely translated into public policies that improve the health and well-being of people experiencing serious disorders. I advocate here for investment in policymaker-scientist networks dedicated to such translation for a range of diseases. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.08.016
更新日期：2019-09-25 00:00:00
abstract：:Flux of substrate and charge mediated by three cloned excitatory amino acid transporters widely expressed in human brain were studied in voltage-clamped Xenopus oocytes. Superfusion of L-glutamate or D-aspartate resulted in currents due in part to electrogenic Na+ cotransport, which contributed 1 net positive charge p...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90159-0
更新日期：1995-09-01 00:00:00
abstract：:Aβ Immunotherapy is a promising therapeutic approach for Alzheimer's disease. Preclinical studies demonstrate that plaque prevention is possible; however, the more relevant therapeutic removal of existing plaque has proven elusive. Monoclonal antibodies in development target both soluble and insoluble Aβ peptide. We h...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.10.029
更新日期：2012-12-06 00:00:00
abstract：:Astrocytes release glutamate, which can modulate nearby synapses, but how this release is accomplished remains debated. In this issue of Neuron, Yang et al. (2019) show that the volume-regulated anion channel Swell1 in astrocytes mediates the release of glutamate and impacts synaptic transmission, learning and memory,...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.05.005
更新日期：2019-05-22 00:00:00
abstract：:Declarative memories are thought to be stored within anatomically distributed neuronal networks requiring the hippocampus; however, it is unclear how neocortical areas participate in memory at the time of encoding. Here, we use a c-fos-based genetic tagging system to selectively express the channelrhodopsin variant, C...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.09.022
更新日期：2014-10-22 00:00:00
abstract：:Currently there is no general approach for achieving specific optogenetic control of genetically defined cell types in rats, which provide a powerful experimental system for numerous established neurophysiological and behavioral paradigms. To overcome this challenge we have generated genetically restricted recombinase...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.10.028
更新日期：2011-12-08 00:00:00
abstract：UNLABELLED:Human induced pluripotent stem cells (iPSCs) from a healthy 86-year-old male were differentiated into neural stem cells and grafted into adult immunodeficient rats after spinal cord injury. Three months after C5 lateral hemisections, iPSCs survived and differentiated into neurons and glia and extended tens o...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.07.014
更新日期：2014-08-20 00:00:00
abstract：:Vaccinia virus can be used to infect cells in the CNS of frogs, Xenopus laevis, and Rana pipiens, both in vivo and in vitro. In vivo infections were accomplished by injection of viral solution into the tectal ventricle of stage 40-48 tadpoles or by local injections into distinct neural regions. Infections with high ti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90211-2
更新日期：1995-04-01 00:00:00
abstract：:In situ hybridization histochemistry reveals localized expression of the nicotinic acetylcholine receptor (nAChR) alpha 2 subunit mRNA restricted to the lateral spiriform nucleus (SpL) of the chick diencephalon. The alpha 2 nAChR transcripts are not detected in immature SpL neurons at 4.5-5 days of embryonic developme...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90032-b
更新日期：1990-07-01 00:00:00
abstract：:To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00682-2
更新日期：2003-10-30 00:00:00
abstract：:Serotonergic neurons are thought to play a role in depression and obsessive compulsive disorder. However, their functional transmitter repertoire is incompletely known. To investigate this repertoire, intracellular recordings were obtained from 132 cytochemically identified rat mesopontine serotonergic neurons that ha...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90283-6
更新日期：1994-02-01 00:00:00
abstract：:To clarify the organization of motor representations in posterior parietal cortex, we test how three motor variables (body side, body part, cognitive strategy) are coded in the human anterior intraparietal cortex. All tested movements were encoded, arguing against strict anatomical segregation of effectors. Single uni...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.06.040
更新日期：2017-08-02 00:00:00
abstract：:We have studied the expression of NGF receptor (NGFR) mRNA in the mouse trigeminal system at closely staged intervals throughout development. The level of NGFR mRNA per neuron is at a constant low level before the earliest axons reach the target field and increases 5-fold to plateau shortly after the arrival of the la...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90054-j
更新日期：1990-03-01 00:00:00
abstract：:Cortical motor areas are thought to contribute "higher-order processing," but what that processing might include is unknown. Previous studies of the smooth pursuit-related discharge of supplementary eye field (SEF) neurons have not distinguished activity associated with the preparation for pursuit from discharge relat...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.05.010
更新日期：2009-06-11 00:00:00
abstract：:The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading "activation memories" between inhibitory synapses. Glutamaterg...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.06.022
更新日期：2017-07-05 00:00:00
