Abstract:
:To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synaptic structure and function were not altered. However, 1 week after PSC ablation, presynaptic function decreased by approximately half, while postsynaptic function was unchanged. Retraction of nerve terminals increased over 10-fold at PSC-ablated NMJs. Furthermore, nerve-evoked muscle twitch tension was reduced. In tadpoles, repeated in vivo observations revealed that PSC processes lead nerve terminal growth. In the absence of PSCs, growth and addition of synapses was dramatically reduced, and existing synapses underwent widespread retraction. Our findings provide in vivo evidence that glial cells maintain presynaptic structure and function at adult synapses and are vital for the growth and stability of developing synapses.
journal_name
Neuronjournal_title
Neuronauthors
Reddy LV,Koirala S,Sugiura Y,Herrera AA,Ko CPdoi
10.1016/s0896-6273(03)00682-2subject
Has Abstractpub_date
2003-10-30 00:00:00pages
563-80issue
3eissn
0896-6273issn
1097-4199pii
S0896627303006822journal_volume
40pub_type
杂志文章相关文献
NEURON文献大全abstract::Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's disease (AD) bring cholesterol to the forefront of AD research. Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and t...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(03)00840-7
更新日期:2004-01-08 00:00:00
abstract::The dynamic interactions between hippocampus and amygdala are critical for emotional memory. Theta synchrony between these structures occurs during fear memory retrieval and may facilitate synaptic plasticity, but the cellular mechanisms are unknown. We report that interneurons of the mouse basal amygdala are activate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.08.024
更新日期:2015-09-23 00:00:00
abstract::Brain circuits endow behavioral flexibility. Here, we study circuits encoding flexible chemotaxis in C. elegans, where the animal navigates up or down NaCl gradients (positive or negative chemotaxis) to reach the salt concentration of previous growth (the set point). The ASER sensory neuron mediates positive and negat...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.05.010
更新日期:2014-06-04 00:00:00
abstract::Contexts exert bi-directional control over relapse to drug seeking. Contexts associated with drug self-administration promote relapse, whereas contexts associated with the absence of self-administration protect against relapse. The nucleus accumbens shell (AcbSh) is a key brain region determining these roles of contex...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.03.033
更新日期:2018-05-02 00:00:00
abstract::GABAergic interneurons play critical roles in seizures, but it remains unknown whether these vary across interneuron subtypes or evolve during a seizure. This uncertainty stems from the unpredictable timing of seizures in most models, which limits neuronal imaging or manipulations around the seizure onset. Here, we de...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.11.043
更新日期:2017-01-18 00:00:00
abstract::We perceive motion when presented with spatiotemporal changes in contrast (second-order cue). This requires linear signals to be rectified and then summed in temporal order to compute direction. Although both operations have been attributed to cortex, rectification might occur in retina, prior to the ganglion cell. He...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00484-6
更新日期:2001-11-20 00:00:00
abstract::A fundamental question about the neural correlates of attention concerns the earliest sensory processing stage that it can affect. We addressed this issue by recording magnetoencephalography (MEG) signals while subjects performed detection tasks, which required employment of spatial or nonspatial attention, in auditor...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.04.013
更新日期:2008-06-12 00:00:00
abstract::An impressive body of research over the past 30 years has implicated the human cerebellum in a broad range of functions, including motor control, perception, language, working memory, cognitive control, and social cognition. The relatively uniform anatomy and physiology of the cerebellar cortex has given rise to the i...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.04.021
更新日期:2019-06-05 00:00:00
abstract::Interaction with the multi-PDZ protein GRIP is required for the synaptic targeting of AMPA receptors, but the underlying mechanism is unknown. We show that GRIP binds to the liprin-alpha/SYD2 family of proteins that interact with LAR receptor protein tyrosine phosphatases (LAR-RPTPs) and that are implicated in presyna...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00640-2
更新日期:2002-03-28 00:00:00
abstract::Elucidating the molecular mechanisms underlying quantitative neurocognitive phenotypes will further our understanding of the brain's structural and functional architecture and advance the diagnosis and treatment of the psychiatric disorders that these traits underlie. Although many neurocognitive traits are highly her...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2010.10.007
更新日期:2010-10-21 00:00:00
abstract::Recent advances in connectomics have led to a synthesis of perspectives regarding the brain's functional organization that reconciles classical concepts of localized specialization with an appreciation for properties that emerge from interactions across distributed functional networks. This provides a more comprehensi...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2016.07.031
更新日期:2016-08-03 00:00:00
abstract::To evaluate the role in synaptic plasticity of ryanodine receptor type 3 (RyR3), which is normally enriched in hippocampal area CA1, we generated RyR3-deficient mice. Mutant mice exhibited facilitated CA1 long-term potentiation (LTP) induced by short tetanus (100 Hz, 100 ms) stimulation. Unlike LTP in wild-type mice, ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81123-x
更新日期:1999-11-01 00:00:00
abstract::To assess the necessary parameters for the growth of axons within the adult rat CNS, we have used intracerebral grafts of primary fibroblasts genetically engineered to express nerve growth factor (NGF). Following the implantation of NGF-producing primary fibroblasts within the striatum, cholinergic axons arising from ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90346-2
更新日期:1991-12-01 00:00:00
abstract::At early developmental stages (embryonic day 7, E7), chick paravertebral sympathetic ganglia contain a cell population that divides in culture while expressing various neuronal properties. In an attempt to identify factors that control neuronal proliferation, we found that ciliary neurotrophic factor (CNTF) specifical...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90312-7
更新日期:1989-03-01 00:00:00
abstract::Hippocampal replays have been demonstrated to play a crucial role in memory. Chains of ripples (ripple bursts) in CA1 have been reported to co-occur with long-range place cell sequence replays during the quiet awake state, but roles of neural inputs to CA1 in ripple bursts and replays are unknown. Here we show that ri...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.09.017
更新日期:2017-09-27 00:00:00
abstract::To advance the understanding of sleep regulation, we screened for sleep-promoting cells and identified neurons expressing neuropeptide Y-like short neuropeptide F (sNPF). Sleep induction by sNPF meets all relevant criteria. Rebound sleep following sleep deprivation is reduced by activation of sNPF neurons, and flies e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.07.029
更新日期:2013-10-02 00:00:00
abstract::The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RI...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2005.06.002
更新日期:2005-06-16 00:00:00
abstract::Memory distortions and illusions have been thoroughly documented in psychological studies, but little is known about the neuroanatomical correlates of true and false memories. Vivid but illusory memories can be induced by asking people whether they recall or recognize words that were not previously presented, but are ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80158-0
更新日期:1996-08-01 00:00:00
abstract::Direct brain stimulation has diverse effects on network activity. In this issue of Neuron, Qiao et al. (2020) demonstrate a novel approach for using stimulation to characterize and modulate interactions between areas of the mood processing network. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2020.08.008
更新日期:2020-09-09 00:00:00
abstract::The decision to engage in one behavior often precludes the selection of others, suggesting cross-inhibition between incompatible behaviors. For example, the likelihood to initiate feeding might be influenced by an animal's commitment to other behaviors. Here, we examine the modulation of feeding behavior in the fruit ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.06.018
更新日期:2013-08-21 00:00:00
abstract::Intracortical somatosensory interfaces have now entered the clinical domain. Darie et al. explore the implications of research published in Science Translational Medicine by Flesher et al. (2016), discuss how to design such a system given current technology, and question how to effectively communicate with users about...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.02.008
更新日期:2017-02-22 00:00:00
abstract::Memory decline in aging results from multiple factors that influence both executive function and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems are preferentially vulnerable to white matter change, atrophy, and certain forms of neurotransmitter depletion. Frontal-striatal change ma...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2004.09.006
更新日期:2004-09-30 00:00:00
abstract::The slow (<1 Hz) rhythm is a defining feature of the electroencephalogram during sleep. Since cortical circuits can generate this rhythm in isolation, it is assumed that the accompanying slow oscillation in thalamocortical (TC) neurons is largely a passive reflection of neocortical activity. Here we show, however, tha...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00623-2
更新日期:2002-03-14 00:00:00
abstract::The eye often leads the way in the development of novel strategies for treating neurodegenerative disorders. Here, we highlight an exciting new study examining the potential for reactivating endogenous repair mechanisms and enabling the mammalian retina to repair itself. ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.10.035
更新日期:2018-11-07 00:00:00
abstract::Spontaneous activity patterns in the developing retina appear important for the functional organization of the visual system. We show here that an absence of early retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) is associated with both gain and loss of functional organiz...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00789-x
更新日期:2003-12-18 00:00:00
abstract::Hippocampal dentate granule cell abnormalities are thought to play a causative role in temporal lobe epilepsy, but their precise contribution has not been dissociated from coexisting pathological changes. In this issue of Neuron, Pun et al. (2012) show, for the first time, that inducing proexcitatory changes in a subs...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2012.09.008
更新日期:2012-09-20 00:00:00
abstract::Propagation in higher animals requires the efficient and accurate display of innate mating behaviors. In Drosophila melanogaster, male courtship consists of a stereotypic sequence of behaviors involving multiple sensory modalities, such as vision, audition, and chemosensation. For example, taste bristles located in th...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00542-7
更新日期:2003-09-11 00:00:00
abstract::Using a novel visual-tactile paradigm in rats, Nikbakht et al. (2018) describe multisensory behavior that outperformed predictions of optimal cue combination (indicating cross-modal synergy) and exposed encoding in PPC neurons (of stimulus and choice signals) that was independent of stimulus modality. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.01.041
更新日期:2018-02-07 00:00:00
abstract::We developed a large-scale dynamical model of the macaque neocortex, which is based on recently acquired directed- and weighted-connectivity data from tract-tracing experiments, and which incorporates heterogeneity across areas. A hierarchy of timescales naturally emerges from this system: sensory areas show brief, tr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.09.008
更新日期:2015-10-21 00:00:00
abstract::The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)01101-7
更新日期:2002-12-19 00:00:00