Abstract:
:The relative timing of presynaptic and postsynaptic spikes plays a critical role in activity-induced synaptic modification. Here we examined whether plasticity of orientation selectivity in the visual cortex depends on stimulus timing. Repetitive pairing of visual stimuli at two orientations induced a shift in orientation tuning of cat cortical neurons, with the direction of the shift depending on the temporal order of the pair. Induction of a significant shift required that the interval between the pair fall within +/-40 ms, reminiscent of the temporal window for spike timing-dependent synaptic plasticity. Mirroring the plasticity found in cat visual cortex, similar conditioning also induced a shift in perceived orientation by human subjects, further suggesting functional relevance of this phenomenon. Thus, relative timing of visual stimuli can play a critical role in dynamic modulation of adult cortical function, perhaps through spike timing-dependent synaptic plasticity.
journal_name
Neuronjournal_title
Neuronauthors
Yao H,Dan Ydoi
10.1016/s0896-6273(01)00460-3subject
Has Abstractpub_date
2001-10-25 00:00:00pages
315-23issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(01)00460-3journal_volume
32pub_type
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