当前位置： SCI文献检索 > NEURON期刊下所有文献 > Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia.

Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia.

Abstract：

:Embryonic retinal ganglion cell (RGC) axons must extend toward and grow through the optic disc to exit the eye into the optic nerve. In the embryonic mouse eye, we found that immunoreactivity for the axon guidance molecule netrin-1 was specifically on neuroepithelial cells at the disk surrounding exiting RGC axons, and RGC axons express the netrin receptor, DCC (deleted in colorectal cancer). In vitro, anti-DCC antibodies reduced RGC neurite outgrowth responses to netrin-1. In netrin-1- and DCC-deficient embryos, RGC axon pathfinding to the disc was unaffected; however, axons failed to exit into the optic nerve, resulting in optic nerve hypoplasia. Thus, netrin-1 through DCC appears to guide RGC axons locally at the optic disc rather than at long range, apparently reflecting the localization of netrin-1 protein to the vicinity of netrin-1-producing cells at the optic disc.

journal_name

Neuron

journal_title

Neuron

authors

Deiner MS,Kennedy TE,Fazeli A,Serafini T,Tessier-Lavigne M,Sretavan DW

doi

10.1016/s0896-6273(00)80373-6

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

575-89

issue

3

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(00)80373-6

journal_volume

19

pub_type

杂志文章

相关文献

NEURON文献大全
  • The cortical control of movement revisited.

    abstract：:Recently, we found that electrical stimulation of motor cortex caused monkeys to make coordinated, complex movements. These evoked movements were arranged across the cortex in a map of spatial locations to which the hand moved. We suggest that some of the subdivisions previously described within primary motor and prem...

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/s0896-6273(02)01003-6

    authors： Graziano MS,Taylor CS,Moore T,Cooke DF

    更新日期：2002-10-24 00:00:00

  • Undercover Power of Endocannabinoids: Postsynaptic Ion-Channel Modulator.

    abstract：:In this issue of Neuron, Gantz and Bean (2017) show that the endocannabinoid 2-arachidonoyl glycerol (2-AG) can directly alter the properties of native ion-channel Kv4.3 and accelerate the pacemaker activity of rodent dopamine neurons. These findings are one of the first demonstrations of postsynaptic, cell-autonomous...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2017.03.014

    authors： Matsui A,Alvarez VA

    更新日期：2017-03-22 00:00:00

  • Rabies Virus CVS-N2c(ΔG) Strain Enhances Retrograde Synaptic Transfer and Neuronal Viability.

    abstract：:Virally based transsynaptic tracing technologies are powerful experimental tools for neuronal circuit mapping. The glycoprotein-deletion variant of the SAD-B19 vaccine strain rabies virus (RABV) has been the reagent of choice in monosynaptic tracing, since it permits the mapping of synaptic inputs to genetically marke...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2016.01.004

    authors： Reardon TR,Murray AJ,Turi GF,Wirblich C,Croce KR,Schnell MJ,Jessell TM,Losonczy A

    更新日期：2016-02-17 00:00:00

  • The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211.

    abstract：:Myelin ensheathes axons to allow rapid propagation of action potentials and proper nervous system function. In the peripheral nervous system, Schwann cells (SCs) radially sort axons into a 1:1 relationship before wrapping an axonal segment to form myelin. SC myelination requires the adhesion G protein-coupled receptor...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2014.12.057

    authors： Petersen SC,Luo R,Liebscher I,Giera S,Jeong SJ,Mogha A,Ghidinelli M,Feltri ML,Schöneberg T,Piao X,Monk KR

    更新日期：2015-02-18 00:00:00

  • mTOR'ing across the Cortex by Chopping the Cilia.

    abstract：:Somatic mutation of the MTOR gene is a genetic etiology of focal malformations of cortical development. In this issue of Neuron, Park et al. (2018) identify defective autophagy-dependent ciliogenesis/Wnt signaling as an underlying mechanism affecting neuronal migration and cortical lamination. ...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2018.06.042

    authors： Di Nardo A,Sahin M

    更新日期：2018-07-11 00:00:00

  • Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases.

    abstract：:During development of the peripheral nervous system (PNS), Schwann-cell-secreted gliomedin induces the clustering of Na+ channels at the edges of each myelin segment to form nodes of Ranvier. Here we show that bone morphogenetic protein-1 (BMP1)/Tolloid (TLD)-like proteinases confine Na+ channel clustering to these si...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2020.03.001

    authors： Eshed-Eisenbach Y,Devaux J,Vainshtein A,Golani O,Lee SJ,Feinberg K,Sukhanov N,Greenspan DS,Susuki K,Rasband MN,Peles E

    更新日期：2020-06-03 00:00:00

  • Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach.

    abstract：:The precise subunit composition of synaptic ionotropic receptors in the brain is poorly understood. This information is of particular importance with regard to AMPA-type glutamate receptors, the multimeric complexes assembled from GluA1-A4 subunits, as the trafficking of these receptors into and out of synapses is pro...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2009.02.027

    authors： Lu W,Shi Y,Jackson AC,Bjorgan K,During MJ,Sprengel R,Seeburg PH,Nicoll RA

    更新日期：2009-04-30 00:00:00

  • When good enough is best.

    abstract：:In this issue of Neuron, Rinberg et al. show that mice use a speed-accuracy tradeoff in odor discrimination. Shorter sampling results in high performance for easy problems, and enforced longer sampling results in higher accuracy for difficult problems, but mice freely choose intermediate sampling durations and accurac...

    journal_title：Neuron

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.neuron.2006.07.015

    authors： Kay LM,Beshel J,Martin C

    更新日期：2006-08-03 00:00:00

  • Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System.

    abstract：:Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose and many neuropsychiatric comorbidities. Uncovering the mechanisms responsible for pain-induced negative affect is critical in addressing these comorbid outcomes...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2019.02.029

    authors： Massaly N,Copits BA,Wilson-Poe AR,Hipólito L,Markovic T,Yoon HJ,Liu S,Walicki MC,Bhatti DL,Sirohi S,Klaas A,Walker BM,Neve R,Cahill CM,Shoghi KI,Gereau RW 4th,McCall JG,Al-Hasani R,Bruchas MR,Morón JA

    更新日期：2019-05-08 00:00:00

  • Differential expression of the neuronal acetylcholine receptor alpha 2 subunit gene during chick brain development.

    abstract：:In situ hybridization histochemistry reveals localized expression of the nicotinic acetylcholine receptor (nAChR) alpha 2 subunit mRNA restricted to the lateral spiriform nucleus (SpL) of the chick diencephalon. The alpha 2 nAChR transcripts are not detected in immature SpL neurons at 4.5-5 days of embryonic developme...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/0896-6273(90)90032-b

    authors： Daubas P,Devillers-Thiéry A,Geoffroy B,Martinez S,Bessis A,Changeux JP

    更新日期：1990-07-01 00:00:00

  • Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body.

    abstract：:In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2016.04.034

    authors： Perisse E,Owald D,Barnstedt O,Talbot CB,Huetteroth W,Waddell S

    更新日期：2016-06-01 00:00:00

  • PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse.

    abstract：:Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to an increase of clathrin-coated intermediates and of polymerized actin at endocytic zones of nerve terminals. These changes correlate with elevated levels of PI(4,5)P(2) in neurons. We report that phosphatidylinositol ph...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(01)00456-1

    authors： Wenk MR,Pellegrini L,Klenchin VA,Di Paolo G,Chang S,Daniell L,Arioka M,Martin TF,De Camilli P

    更新日期：2001-10-11 00:00:00

  • Translational control of BACE1 may go awry in Alzheimer's disease.

    abstract：:Our understanding of the mechanisms whereby BACE1, the aspartyl protease required for the initial cleavage of APP to generate amyloid-beta (Abeta), is regulated in Alzheimer's disease (AD) remains incomplete. In this issue of Neuron, O'Connor and coworkers show how energy deprivation, a potential risk factor in AD, tr...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2008.12.010

    authors： Wong PC

    更新日期：2008-12-26 00:00:00

  • A modeling framework for deriving the structural and functional architecture of a short-term memory microcircuit.

    abstract：:Although many studies have identified neural correlates of memory, relatively little is known about the circuit properties connecting single-neuron physiology to behavior. Here we developed a modeling framework to bridge this gap and identify circuit interactions capable of maintaining short-term memory. Unlike typica...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2013.06.041

    authors： Fisher D,Olasagasti I,Tank DW,Aksay ER,Goldman MS

    更新日期：2013-09-04 00:00:00

  • The Jak/STAT pathway is involved in synaptic plasticity.

    abstract：:The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcriptio...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2011.11.024

    authors： Nicolas CS,Peineau S,Amici M,Csaba Z,Fafouri A,Javalet C,Collett VJ,Hildebrandt L,Seaton G,Choi SL,Sim SE,Bradley C,Lee K,Zhuo M,Kaang BK,Gressens P,Dournaud P,Fitzjohn SM,Bortolotto ZA,Cho K,Collingridge GL

    更新日期：2012-01-26 00:00:00

  • TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C. elegans.

    abstract：:Membrane excitability is a fundamentally important feature for all excitable cells including both neurons and muscle cells. However, the background depolarizing conductances in excitable cells, especially in muscle cells, are not well characterized. Although mutations in transmembrane channel-like (TMC) proteins TMC1 ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2017.12.041

    authors： Yue X,Zhao J,Li X,Fan Y,Duan D,Zhang X,Zou W,Sheng Y,Zhang T,Yang Q,Luo J,Duan S,Xiao R,Kang L

    更新日期：2018-02-07 00:00:00

  • Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking.

    abstract：:The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for information processing in neural circuits. However, little is known about the spatial principles of E and I synaptic organization across the entire dendritic tree of mammalian neurons. We developed a new open-source reconstr...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2020.02.015

    authors： Iascone DM,Li Y,Sümbül U,Doron M,Chen H,Andreu V,Goudy F,Blockus H,Abbott LF,Segev I,Peng H,Polleux F

    更新日期：2020-05-20 00:00:00

  • Medial Entorhinal Cortex Selectively Supports Temporal Coding by Hippocampal Neurons.

    abstract：:Recent studies have shown that hippocampal "time cells" code for sequential moments in temporally organized experiences. However, it is currently unknown whether these temporal firing patterns critically rely on upstream cortical input. Here we employ an optogenetic approach to explore the effect of large-scale inacti...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2017.04.003

    authors： Robinson NTM,Priestley JB,Rueckemann JW,Garcia AD,Smeglin VA,Marino FA,Eichenbaum H

    更新日期：2017-05-03 00:00:00

  • Sweet successes.

    abstract：:Mapping of the chromosomal location of genes essential for sweet and bitter taste and identification of the relevant G protein-coupled receptors reveals unanticipated complexity in taste signaling pathways. The distribution of sweet and bitter receptors suggests complete cellular segregation of these taste modalities....

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/s0896-6273(01)00404-4

    authors： Lewcock JW,Reed RR

    更新日期：2001-08-30 00:00:00

  • Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3.

    abstract：:The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of b...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/s0896-6273(03)00368-4

    authors： Meng Y,Zhang Y,Jia Z

    更新日期：2003-07-03 00:00:00

  • Rapid Integration of Artificial Sensory Feedback during Operant Conditioning of Motor Cortex Neurons.

    abstract：:Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced. Here we asked if cortical stimulation could provide artificial feedback during operant conditioning of cortical neurons. Simultaneous two-photon imaging and real-t...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2017.01.023

    authors： Prsa M,Galiñanes GL,Huber D

    更新日期：2017-02-22 00:00:00

  • Self-recognition at the atomic level: understanding the astonishing molecular diversity of homophilic Dscams.

    abstract：:The Drosophila Dscams are immunoglobulin superfamily members produced from a single gene that is diversified by alternative splicing to produce a family of cell-surface proteins with over 19,000 different ectodomain isoforms. Dscams are critical for neuronal wiring, and mounting evidence suggests that they play a key ...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2007.09.024

    authors： Shapiro L

    更新日期：2007-10-04 00:00:00

  • Epimetronomics: m6A Marks the Tempo of Corticogenesis.

    abstract：:Yoon et al. (2017) uncover a key role for the m6A RNA mark in regulating the timing of cerebral cortex development in mouse and human. This discovery opens new avenues of exploration into how the epitranscriptome helps orchestrate central nervous system formation. ...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2017.11.002

    authors： Boles NC,Temple S

    更新日期：2017-11-15 00:00:00

  • Feedforward to the past: the relation between neuronal connectivity, amplification, and short-term memory.

    abstract：:Two studies in this issue of Neuron challenge widely held assumptions about the role of positive feedback in recurrent neuronal networks. Goldman shows that such feedback is not necessary for memory maintenance in a neural integrator, and Murphy and Miller show that it is not necessary for amplification of orientation...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2009.02.006

    authors： Ganguli S,Latham P

    更新日期：2009-02-26 00:00:00

  • The Theta Rhythm Mixes and Matches Gamma Oscillations Cycle by Cycle.

    abstract：:In the hippocampus, gamma power modulation by the theta rhythm is interpreted as the signature of temporally coordinated inputs that reflect ongoing processing. In this issue of Neuron, Lopes-Dos-Santos et al. (2018) develop a new methodology demonstrating that theta cycles can be viewed as individual computational un...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2018.11.008

    authors： Bagur S,Benchenane K

    更新日期：2018-11-21 00:00:00

  • Excitation-Transcription Coupling in Parvalbumin-Positive Interneurons Employs a Novel CaM Kinase-Dependent Pathway Distinct from Excitatory Neurons.

    abstract：:Properly functional CNS circuits depend on inhibitory interneurons that in turn rely upon activity-dependent gene expression for morphological development, connectivity, and excitatory-inhibitory coordination. Despite its importance, excitation-transcription coupling in inhibitory interneurons is poorly understood. We...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2016.03.001

    authors： Cohen SM,Ma H,Kuchibhotla KV,Watson BO,Buzsáki G,Froemke RC,Tsien RW

    更新日期：2016-04-20 00:00:00

  • Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction.

    abstract：:The histone deacetylase HDAC5 has been shown to regulate behavioral adaptations to cocaine. In this issue of Neuron, Taniguchi et al. (2012) describe a cAMP-dependent signaling pathway that regulates nuclear accumulation of HDAC5, suggesting a mechanism to couple cocaine with changes in HDAC5 function. ...

    journal_title：Neuron

    pub_type： 评论,杂志文章

    doi：10.1016/j.neuron.2011.12.016

    authors： West AE

    更新日期：2012-01-12 00:00:00

  • Conscious Processing and the Global Neuronal Workspace Hypothesis.

    abstract：:We review the central tenets and neuroanatomical basis of the global neuronal workspace (GNW) hypothesis, which attempts to account for the main scientific observations regarding the elementary mechanisms of conscious processing in the human brain. The GNW hypothesis proposes that, in the conscious state, a non-linear...

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuron.2020.01.026

    authors： Mashour GA,Roelfsema P,Changeux JP,Dehaene S

    更新日期：2020-03-04 00:00:00

  • NCAM 180 acting via a conserved C-terminal domain and MLCK is essential for effective transmission with repetitive stimulation.

    abstract：:NCAM 180 isoform null neuromuscular junctions are unable to effectively mobilize and exocytose synaptic vesicles and thus exhibit periods of total transmission failure during high-frequency repetitive stimulation. We have identified a highly conserved C-terminal (KENESKA) domain on NCAM that is required to maintain ef...

    journal_title：Neuron

    pub_type： 杂志文章

    doi：10.1016/j.neuron.2005.05.018

    authors： Polo-Parada L,Plattner F,Bose C,Landmesser LT

    更新日期：2005-06-16 00:00:00

  • Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.

    abstract：:Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein. There are currently no disease-modifying therapies available, but approaches that target proximally in disease pathogenesis hold gre...

    journal_title：Neuron

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuron.2019.01.039

    authors： Tabrizi SJ,Ghosh R,Leavitt BR

    更新日期：2019-03-06 00:00:00