When good enough is best.

abstract：:To assess the role of exocytotic release in signaling by monoamines, we have disrupted the neuronal vesicular monoamine transporter 2 (VMAT2) gene. VMAT2-/- mice move little, feed poorly, and die within a few days after birth. Monoamine cell groups and their projections are indistinguishable from those of wild-type li...

journal_title：Neuron

authors： Fon EA,Pothos EN,Sun BC,Killeen N,Sulzer D,Edwards RH

更新日期：1997-12-01 00:00:00

abstract：:EPAC proteins are the guanine nucleotide exchange factors that act as the intracellular receptors for cyclic AMP. Two variants of EPAC genes including EPAC1 and EPAC2 are cloned and are widely expressed throughout the brain. But, their functions in the brain remain unknown. Here, we genetically delete EPAC1 (EPAC1(-/-...

journal_title：Neuron

authors： Yang Y,Shu X,Liu D,Shang Y,Wu Y,Pei L,Xu X,Tian Q,Zhang J,Qian K,Wang YX,Petralia RS,Tu W,Zhu LQ,Wang JZ,Lu Y

更新日期：2012-02-23 00:00:00

abstract：:Sonic hedgehog (Shh) is a putative morphogen secreted by the floor plate and notochord, which specifies the fate of multiple cell types in the ventral aspect of the vertebrate nervous system. Since in Drosophila the actions of Hh have been shown to be transduced by Cubitus interruptus (Ci), a zinc finger transcription...

journal_title：Neuron

authors： Hynes M,Stone DM,Dowd M,Pitts-Meek S,Goddard A,Gurney A,Rosenthal A

更新日期：1997-07-01 00:00:00

abstract：:The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV cargo occurs at the plasma membrane. Activity-dependent bulk endocytosis (ADBE) ...

journal_title：Neuron

authors： Nicholson-Fish JC,Kokotos AC,Gillingwater TH,Smillie KJ,Cousin MA

更新日期：2015-12-02 00:00:00

abstract：:Presynaptic CaV2 channels are essential for Ca2+-triggered exocytosis. In addition, there are two competing models for their roles in synapse structure. First, Ca2+ channels or Ca2+ entry may control synapse assembly. Second, active zone proteins may scaffold CaV2s to presynaptic release sites, and synapse structure i...

journal_title：Neuron

authors： Held RG,Liu C,Ma K,Ramsey AM,Tarr TB,De Nola G,Wang SSH,Wang J,van den Maagdenberg AMJM,Schneider T,Sun J,Blanpied TA,Kaeser PS

更新日期：2020-08-19 00:00:00

abstract：:Using high resolution capacitance measurements, we have characterized an ultrafast component of transmitter release in ribbon-type synaptic terminals of retinal bipolar neurons. During depolarization, capacitance increases to a plateau of approximately 30 fF with a time constant of approximately 1.5 ms. When not limit...

journal_title：Neuron

authors： Mennerick S,Matthews G

更新日期：1996-12-01 00:00:00

abstract：:In this issue of Neuron, Luo and Maunsell (2018) use signal detection theory to demonstrate that the modulatory effects of attention on neuronal responses in the lateral prefrontal cortex during change detection can be due to changes in an observer's sensitivity or shifts in their response criterion. ...

journal_title：Neuron

authors： Martinez-Trujillo J,Gulli RA

更新日期：2018-03-21 00:00:00

abstract：:The regulation of quantal size through pre- rather than postsynaptic mechanisms has recently received considerable attention as a potential mechanism for plasticity. Vesicular transporters catalyze the filling of synaptic vesicles with transmitter and are thus potential substrates for such presynaptic regulation. In t...

journal_title：Neuron

authors： Hnasko TS,Edwards RH

更新日期：2006-09-07 00:00:00

abstract：:Membrane potential recordings in awake mice have correlated cortical state with locomotion and whisker movements. In this issue of Neuron, Reimer et al. (2014) now reveal that pupil dilation in stationary mice equally signals a change in cortical state and an enhancement of visual processing. ...

journal_title：Neuron

authors： Poulet JF

更新日期：2014-10-22 00:00:00

abstract：:Cued spatial attention differentially modulates alpha power in attended relative to non-attended brain representations, termed the alpha asymmetry. Yet a causal role for alpha in attention is debated. In this issue of Neuron, Bagherzadeh et al., (2019) utilize neurofeedback to train alpha asymmetry and causally impact...

journal_title：Neuron

authors： Jones SR,Sliva DD

更新日期：2020-02-05 00:00:00

abstract：:Quantitative differences in cadherin activity have been proposed to play important roles in patterning connections between pre- and postsynaptic neurons. However, no examples of such a function have yet been described, and the mechanisms that would allow such differences to direct growth cones to specific synaptic tar...

journal_title：Neuron

authors： Chen PL,Clandinin TR

更新日期：2008-04-10 00:00:00

abstract：:Tau is abundant in the axon, whereas MAP2 is found in the cell body and dendrites. To understand their differential localization, we performed transfection studies on primary cultured neurons using tagged tau, MAP2, MAP2C, and their chimeric/deletion mutants. We found that MAP2 was prevented from entering the axon by ...

journal_title：Neuron

authors： Kanai Y,Hirokawa N

更新日期：1995-02-01 00:00:00

abstract：:The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent ...

journal_title：Neuron

authors： Lee SJ,Montell C

更新日期：2004-07-08 00:00:00

abstract：:Ultrasound has received widespread attention as an emerging technology for targeted, non-invasive neuromodulation based on its ability to evoke electrophysiological and motor responses in animals. However, little is known about the spatiotemporal pattern of ultrasound-induced brain activity that could drive these resp...

journal_title：Neuron

authors： Sato T,Shapiro MG,Tsao DY

更新日期：2018-06-06 00:00:00

abstract：:FLRTs are broadly expressed proteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors. How these functions direct cell behavior and the molecular mechanisms involved remain largely unclear. Here we use X-ray crystallography to revea...

journal_title：Neuron

authors： Seiradake E,del Toro D,Nagel D,Cop F,Härtl R,Ruff T,Seyit-Bremer G,Harlos K,Border EC,Acker-Palmer A,Jones EY,Klein R

更新日期：2014-10-22 00:00:00

abstract：:Two mutations in the sodium channel alpha subunit that have been implicated as the cause of periodic paralysis were studied by functional expression in a mammalian cell line. Both mutations disrupted inactivation without affecting the time course of the onset of the sodium current or the single-channel conductance. Th...

journal_title：Neuron

authors： Cannon SC,Strittmatter SM

更新日期：1993-02-01 00:00:00

abstract：:NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor-expressing cells, and the majority of native receptors are triheteromers containing two GluN1 and two different GluN2. In contrast to diheterome...

journal_title：Neuron

authors： Hansen KB,Ogden KK,Yuan H,Traynelis SF

更新日期：2014-03-05 00:00:00

abstract：:Embryonic retinal ganglion cell (RGC) axons must extend toward and grow through the optic disc to exit the eye into the optic nerve. In the embryonic mouse eye, we found that immunoreactivity for the axon guidance molecule netrin-1 was specifically on neuroepithelial cells at the disk surrounding exiting RGC axons, an...

journal_title：Neuron

authors： Deiner MS,Kennedy TE,Fazeli A,Serafini T,Tessier-Lavigne M,Sretavan DW

更新日期：1997-09-01 00:00:00

abstract：:Gene expression may occur in unexpected ectopic sites when diverse genetic elements are juxtaposed as chimeric genes in transgenic mice. To determine the specific contribution of the promoter and reporter gene in ectopic expression, we have analyzed the expression of 14 different fusion genes in transgenic mice. Chime...

journal_title：Neuron

authors： Russo AF,Crenshaw EB 3rd,Lira SA,Simmons DM,Swanson LW,Rosenfeld MG

更新日期：1988-06-01 00:00:00

abstract：:Microcircuits in different brain areas share similar architectural and biophysical properties with compact motor networks known as central pattern generators (CPGs). Consequently, CPGs have been suggested as valuable biological models for understanding of microcircuit dynamics and particularly, their synchronization. ...

journal_title：Neuron

authors： Szücs A,Huerta R,Rabinovich MI,Selverston AI

更新日期：2009-02-12 00:00:00

abstract：:The processing of sensory information varies widely across behavioral states. However, little is known about how behavioral states modulate the intracellular activity of cortical neurons to effect changes in sensory responses. Here, we performed whole-cell recordings from neurons in upper-layer primary visual cortex o...

journal_title：Neuron

authors： Bennett C,Arroyo S,Hestrin S

更新日期：2013-10-16 00:00:00

abstract：:The presynaptic function of myosin II was studied at cholinergic synapses formed between rat superior cervical ganglion neurons in culture. Immunofluorescent staining showed that myosin II was colocalized with synaptophysin at the presynaptic nerve terminals. Antimyosin II antibody introduced into presynaptic neurons ...

journal_title：Neuron

authors： Mochida S,Kobayashi H,Matsuda Y,Yuda Y,Muramoto K,Nonomura Y

更新日期：1994-11-01 00:00:00

abstract：:Recently, we found that electrical stimulation of motor cortex caused monkeys to make coordinated, complex movements. These evoked movements were arranged across the cortex in a map of spatial locations to which the hand moved. We suggest that some of the subdivisions previously described within primary motor and prem...

journal_title：Neuron

authors： Graziano MS,Taylor CS,Moore T,Cooke DF

更新日期：2002-10-24 00:00:00

abstract：:To learn about the carboxy-terminal extent of amyloid beta-protein (A beta) composition of senile plaques (SPs) in the brain affected with Alzheimer's disease (AD), we employed two end-specific monoclonal antibodies as immunocytochemical probes: one is specific for A beta 40, the carboxyl terminus of A beta 1-40, whil...

journal_title：Neuron

authors： Iwatsubo T,Odaka A,Suzuki N,Mizusawa H,Nukina N,Ihara Y

更新日期：1994-07-01 00:00:00

abstract：:Local axon degeneration is a common pathological feature of many neurodegenerative diseases and peripheral neuropathies. While it is believed to operate with an apoptosis-independent molecular program, the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons,...

journal_title：Neuron

authors： Zhai Q,Wang J,Kim A,Liu Q,Watts R,Hoopfer E,Mitchison T,Luo L,He Z

更新日期：2003-07-17 00:00:00

abstract：:Hippocampal pyramidal cells can be divided into place cells, which fire action potentials when an animal is in specific locations, and silent cells, which are not spatially selective. In this issue of Neuron, Epsztein et al. find intracellular differences between place and silent cells by using whole-cell recordings i...

journal_title：Neuron

authors： Ferguson JE,Jackson JC,Redish AD

更新日期：2011-04-14 00:00:00

abstract：:In this issue of Neuron, Tufail et al. present an underlying mechanism for microglia-mediated elimination of virally transduced cells in the central nervous system. These findings could contribute to the development of improved gene therapies for various neurological disorders by exploring why microglia destroy viable...

journal_title：Neuron

authors： Pluvinage JV,Wyss-Coray T

更新日期：2017-02-08 00:00:00

abstract：:Shaker potassium channels inactivate and recover from inactivation with multiple exponential components, suggesting the presence of multiple inactivation processes. We describe two different types of inactivation in Shaker potassium channels. N-type inactivation can occur as rapidly as a few milliseconds and has been ...

journal_title：Neuron

authors： Hoshi T,Zagotta WN,Aldrich RW

更新日期：1991-10-01 00:00:00

abstract：:We recorded from single neurons in the hippocampus and entorhinal cortex (EC) of rats to investigate the role of these structures in navigation and memory representation. Our results revealed two novel phenomena: first, many cells in CA1 and the EC fired at significantly different rates when the animal was in the same...

journal_title：Neuron

authors： Frank LM,Brown EN,Wilson M

更新日期：2000-07-01 00:00:00

abstract：:Voltage-gated Na(+) channels are the workhorses of spike generation and propagation in excitable cells. Mutations in Na(+) channel genes have been identified in disorders causing episodic dysfunction of heart, skeletal muscle, and brain. Lossin and colleagues from Al George's lab report in this issue of Neuron that th...

journal_title：Neuron

authors： Cannon SC

更新日期：2002-06-13 00:00:00