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PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse.

Abstract：

:Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to an increase of clathrin-coated intermediates and of polymerized actin at endocytic zones of nerve terminals. These changes correlate with elevated levels of PI(4,5)P(2) in neurons. We report that phosphatidylinositol phosphate kinase type Igamma (PIPKIgamma), a major brain PI(4)P 5-kinase, is concentrated at synapses. Synaptojanin 1 and PIPKIgamma antagonize each other in the recruitment of clathrin coats to lipid membranes. Like synaptojanin 1 and other proteins involved in endocytosis, PIPKIgamma undergoes stimulation-dependent dephosphorylation. These results implicate PIPKIgamma in the synthesis of a PI(4,5)P(2) pool that acts as a positive regulator of clathrin coat recruitment and actin function at the synapse.

journal_name

Neuron

journal_title

Neuron

authors

Wenk MR,Pellegrini L,Klenchin VA,Di Paolo G,Chang S,Daniell L,Arioka M,Martin TF,De Camilli P

doi

10.1016/s0896-6273(01)00456-1

subject

Has Abstract

pub_date

2001-10-11 00:00:00

pages

79-88

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(01)00456-1

journal_volume

32

pub_type

杂志文章

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