Abstract:
:Recent advances in brain imaging techniques, including functional magnetic resonance imaging (fMRI), offer great promise for noninvasive mapping of brain function. However, the indirect nature of the imaging signals to the underlying neural activity limits the interpretation of the resulting maps. The present report represents the first systematic study with sufficient statistical power to quantitatively characterize the relationship between changes in blood oxygen content and the neural spiking and synaptic activity. Using two-dimensional optical measurements of hemodynamic signals, simultaneous recordings of neural activity, and an event-related stimulus paradigm, we demonstrate that (1) there is a strongly nonlinear relationship between electrophysiological measures of neuronal activity and the hemodynamic response, (2) the hemodynamic response continues to grow beyond the saturation of electrical activity, and (3) the initial increase in deoxyhemoglobin that precedes an increase in blood volume is counterbalanced by an equal initial decrease in oxyhemoglobin.
journal_name
Neuronjournal_title
Neuronauthors
Devor A,Dunn AK,Andermann ML,Ulbert I,Boas DA,Dale AMdoi
10.1016/s0896-6273(03)00403-3subject
Has Abstractpub_date
2003-07-17 00:00:00pages
353-9issue
2eissn
0896-6273issn
1097-4199pii
S0896627303004033journal_volume
39pub_type
杂志文章相关文献
NEURON文献大全abstract::Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establis...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.05.006
更新日期:2014-07-02 00:00:00
abstract::The dopamine D3 receptor is expressed primarily in regions of the brain that are thought to influence motivation and motor functions. To specify in vivo D3 receptor function, we generated mutant mice lacking this receptor. Our analysis indicates that in a novel environment, D3 mutant mice are transiently more active t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80965-4
更新日期:1997-10-01 00:00:00
abstract::The amplitudes and kinetics of miniature excitatory synaptic currents (MESCs) in mammalian central neurons vary widely. It is unclear whether this variability occurs at each synapse or arises from differences among a heterogeneous population of synapses. Furthermore, it is not known how variability in these currents w...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90073-x
更新日期:1995-07-01 00:00:00
abstract::Visual attention has been classically described as a spotlight that enhances the processing of a behaviorally relevant object. However, in many situations, humans and animals must simultaneously attend to several relevant objects separated by distracters. To account for this ability, various models of attention have b...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.10.013
更新日期:2011-12-22 00:00:00
abstract::The brain must make sense of external stimuli to generate relevant behavior. We used a combination of in vivo approaches to investigate how the cerebellum processes sensory-related information. We found that the inferior olive encodes contexts of sensory-associated external cues in a graded manner, apparent in the pre...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.03.010
更新日期:2019-05-22 00:00:00
abstract::To discover new genes involved in axon navigation, we conducted a forward genetic screen for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU. In Magellan mutant embryos, motor axons were error prone and wandered inefficiently at choice points within embryos, but paradoxic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.09.009
更新日期:2007-11-21 00:00:00
abstract::We have identified the species of K+ channel that underlies the neuronal M-current in rat sympathetic ganglion cells. The channels were kinetically and pharmacologically defined using outside-out and cell-attached patches. They exhibited multiple conductance levels, predominantly 3-9 pS. Their slow gating in response ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90166-o
更新日期:1993-04-01 00:00:00
abstract::The brain has often been described, quite accurately, as one of the most complex objects in the natural world. Understanding its workings, to say nothing about intervening in them, is among the hardest problems in science. While this makes the challenge all the more enticing, in the short term, it acts to limit the im...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.10.044
更新日期:2016-11-02 00:00:00
abstract::The sympathetic innervation of rat sweat glands undergoes a target-induced switch from a noradrenergic to a cholinergic and peptidergic phenotype during development. Treatment of cultured sympathetic neurons with sweat gland extracts mimics many of the changes seen in vivo. Extracts induce choline acetyltransferase ac...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90350-o
更新日期:1990-12-01 00:00:00
abstract::In this issue of Neuron, Wahl et al. demonstrate via invasive recordings from Deep Brain Stimulation leads that the thalamus (but not basal ganglia) is sensitive to certain linguistic violations, consistent with a subcortical role in selective recruitment of language-related cortical areas. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2008.08.015
更新日期:2008-09-11 00:00:00
abstract::In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.03.001
更新日期:2010-03-25 00:00:00
abstract::The molecular mechanisms involved in glial/neuronal fate decisions during embryonic development are largely unknown. Here we show that the segment-polarity gene engrailed, which encodes a homeodomain protein, controls these decisions within an insect CNS lineage. The grasshopper median neuroblast (MNB) generates both ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90024-8
更新日期:1994-09-01 00:00:00
abstract::Glucose-inhibited neurons orchestrate behavior and metabolism according to body energy levels, but how glucose inhibits these cells is unknown. We studied glucose inhibition of orexin/hypocretin neurons, which promote wakefulness (their loss causes narcolepsy) and also regulate metabolism and reward. Here we demonstra...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.04.032
更新日期:2006-06-01 00:00:00
abstract::cGMP has long been suspected to play a role in synaptic plasticity, but the inaccessibility of nerve terminals to electrical recording has impeded tests of this hypothesis. In posterior pituitary nerve terminals, nitric oxide enhanced Ca(2+)-activated K+ channel activity by activating guanylate cyclase and PKG. This e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00449-4
更新日期:2001-09-27 00:00:00
abstract::The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, neurotransmitter release, and potentiated the size, but not the properties, of ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.09.019
更新日期:2009-10-29 00:00:00
abstract::The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related defic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.11.030
更新日期:2010-12-22 00:00:00
abstract::Synaptotagmin 7 (Syt7) was originally identified as a slow Ca2+ sensor for lysosome fusion, but its function at fast synapses is controversial. The paper by Luo and Südhof (2017) in this issue of Neuron shows that at the calyx of Held in the auditory brainstem Syt7 triggers asynchronous release during stimulus trains,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.05.011
更新日期:2017-05-17 00:00:00
abstract::Dendritic spines have been proposed as primary sites of synaptic plasticity in the brain. Consistent with this hypothesis, spines contain high concentrations of actin, suggesting that they might be motile. To investigate this possibility, we made video recordings from hippocampal neurons expressing actin tagged with g...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80467-5
更新日期:1998-05-01 00:00:00
abstract::Two rabbit polyclonal antibodies generated against different portions of the amyloid precursor protein were used to localize this protein in normal rat brain. Light and electron microscopic immunohistochemical localizations demonstrate that the protein is widely distributed throughout the neuraxis, with the highest co...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90131-6
更新日期:1988-11-01 00:00:00
abstract::The hippocampus frequently replays memories of past experiences during sharp-wave ripple (SWR) events. These events can represent spatial trajectories extending from the animal's current location to distant locations, suggesting a role in the evaluation of upcoming choices. While SWRs have been linked to learning and ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.01.027
更新日期:2013-03-20 00:00:00
abstract::Here we describe the properties of a synapse in the Drosophila antennal lobe and show how they can explain certain sensory computations in this brain region. The synapse between olfactory receptor neurons (ORNs) and projection neurons (PNs) is very strong, reflecting a large number of release sites and high release pr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.02.030
更新日期:2008-05-08 00:00:00
abstract::We describe the genetic and kinetic defects in a congenital myasthenic syndrome caused by heteroallelic mutations of the acetylcholine receptor (AChR) epsilon subunit gene. The mutations are an in-frame duplication of six residues in the long cytoplasmic loop (epsilon1254ins18) and a cysteine-loop null mutation (epsil...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80996-4
更新日期:1998-03-01 00:00:00
abstract::Carbon monoxide (CO) induces a long-lasting alteration in cerebellar alpha 3-Na,K-ATPase independent of [Na+] but linked to cGMP synthesis and localized to Purkinje neurons. The action of CO is absent in Purkinje neuron-deficient mice, mimicked by 8-Br-cGMP, and blocked by inhibition of PKG. Glutamate (Glu) and metabo...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90222-8
更新日期:1995-04-01 00:00:00
abstract::NMDA receptor subunit composition varies throughout the brain, providing molecular diversity in NMDA receptor function. The NR2 subunits (NR2A-D) in large part dictate the distinct functional properties of NMDA receptors and differentially regulate receptor trafficking. Although the NR2C subunit is highly enriched in ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.04.015
更新日期:2009-05-28 00:00:00
abstract::The product of the Wnt-1 proto-oncogene is a secreted glycoprotein that is normally produced in regions of the embryonic neural tube. We show here that expression of mouse Wnt-1 cDNA in the rat PC12 pheochromocytoma cell line causes a dramatic conversion from a round to a flat cell morphology. In addition, PC12 cells ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90116-9
更新日期:1993-11-01 00:00:00
abstract::The concept of the CNS as an immune-privileged organ has led to a common misunderstanding that it is not an active immunological organ, guarded from its surroundings by the blood-brain barrier (BBB). Recent advances in this field clearly demonstrate that the CNS is a highly immunologically active organ, with complex i...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2013.04.005
更新日期:2013-04-24 00:00:00
abstract::We determined the cellular substrate for male courtship behavior by quasinatural and artificial stimulation of brain neurons. Activation of fruitless (fru)-expressing neurons via stimulation of thermosensitive dTrpA1 channels induced an entire series of courtship acts in male Drosophila placed alone without any courti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.12.017
更新日期:2011-02-10 00:00:00
abstract::Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental question in addiction biology is why exogenous opiate drugs have a high liability for inducing tolerance and addiction while native ligands do not. Studies indicate that highly addictive opiate d...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)80032-5
更新日期:1999-08-01 00:00:00
abstract::Postlingually deaf subjects learn the meaning of sounds after cochlear implantation by forming new associations between sounds and their sources. Implants generate coarse frequency responses, preventing place-coding fine enough to discriminate sounds with similar temporal characteristics, e.g., buck/duck. This limitat...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00318-x
更新日期:2001-06-01 00:00:00
abstract::Mammals are able to navigate to hidden goal locations by direct routes that may traverse previously unvisited terrain. Empirical evidence suggests that this "vector navigation" relies on an internal representation of space provided by the hippocampal formation. The periodic spatial firing patterns of grid cells in the...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2015.07.006
更新日期:2015-08-05 00:00:00