Nosology of Parkinson's disease: looking for the way out of a quagmire.

abstract：:The neural basis of spatial processing in the auditory cortex has been controversial. Human fMRI studies suggest that a part of the planum temporale (PT) is involved in auditory spatial processing, but it was recently argued that this region is active only when the task requires voluntary spatial localization. If this...

journal_title：Neuron

authors： Deouell LY,Heller AS,Malach R,D'Esposito M,Knight RT

更新日期：2007-09-20 00:00:00

abstract：:We have cloned a Kv2 potassium channel from squid optic lobe termed sqKv2. Multiple overlapping sqKv2 cDNA clones differed from one another at specific positions by purine transitions. To test whether the purine transitions were generated by RNA editing, we compared a 360 nucleotide genomic sequence with corresponding...

journal_title：Neuron

authors： Patton DE,Silva T,Bezanilla F

更新日期：1997-09-01 00:00:00

abstract：:Although associative learning has been localized to specific brain areas in many animals, identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the first demonstration of long-term synaptic plasticity at the output site of the Drosophila mushroom body. Pairing an odor with activati...

journal_title：Neuron

authors： Hige T,Aso Y,Modi MN,Rubin GM,Turner GC

更新日期：2015-12-02 00:00:00

abstract：:People often perceive configurations rather than the elements they comprise, a bias that may emerge because configurations often predict outcomes. But how does the brain learn to associate configurations with outcomes and how does this learning differ from learning about individual elements? We combined behavior, rein...

journal_title：Neuron

authors： Duncan K,Doll BB,Daw ND,Shohamy D

更新日期：2018-05-02 00:00:00

abstract：:The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produc...

journal_title：Neuron

authors： Katz PS

更新日期：1996-02-01 00:00:00

abstract：:Two rabbit polyclonal antibodies generated against different portions of the amyloid precursor protein were used to localize this protein in normal rat brain. Light and electron microscopic immunohistochemical localizations demonstrate that the protein is widely distributed throughout the neuraxis, with the highest co...

journal_title：Neuron

authors： Card JP,Meade RP,Davis LG

更新日期：1988-11-01 00:00:00

abstract：:Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with symptoms including social deficits, anxiety, and communication difficulties. However, ASD pathogenic mechanisms are poorly understood. Mutations of CUL3, which encodes Cullin 3 (CUL3), a component of an E3 ligase complex, are thought of a...

journal_title：Neuron

authors： Dong Z,Chen W,Chen C,Wang H,Cui W,Tan Z,Robinson H,Gao N,Luo B,Zhang L,Zhao K,Xiong WC,Mei L

更新日期：2020-02-05 00:00:00

abstract：:The earliest stages of Alzheimer's disease (AD) are characterized by the formation of mature tangles in the entorhinal cortex and disorientation and confusion when navigating familiar places. The medial entorhinal cortex (MEC) contains specialized neurons called grid cells that form part of the spatial navigation syst...

journal_title：Neuron

authors： Fu H,Rodriguez GA,Herman M,Emrani S,Nahmani E,Barrett G,Figueroa HY,Goldberg E,Hussaini SA,Duff KE

更新日期：2017-02-08 00:00:00

abstract：:The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAAR) signaling in the pancreas. Their molecular mechanism of action, however, remains e...

journal_title：Neuron

authors： Kasaragod VB,Hausrat TJ,Schaefer N,Kuhn M,Christensen NR,Tessmer I,Maric HM,Madsen KL,Sotriffer C,Villmann C,Kneussel M,Schindelin H

更新日期：2019-02-20 00:00:00

abstract：:Fragile X syndrome is a leading heritable cause of mental retardation that results from the loss of FMR1 gene function. A Drosophila model for Fragile X syndrome, based on the loss of dfmr1 activity, exhibits phenotypes that bear similarity to Fragile X-related symptoms. Herein, we demonstrate that treatment with meta...

journal_title：Neuron

authors： McBride SM,Choi CH,Wang Y,Liebelt D,Braunstein E,Ferreiro D,Sehgal A,Siwicki KK,Dockendorff TC,Nguyen HT,McDonald TV,Jongens TA

更新日期：2005-03-03 00:00:00

abstract：:The neurotrophic proteins BDNF and NGF are related in their primary structures, and both have high- and low-affinity receptors on their responsive neurons. In this study, we investigate the extent to which these receptors can discriminate between BDNF and NGF. We found that a 1000-fold excess of the heterologous ligan...

journal_title：Neuron

authors： Rodriguez-Tébar A,Dechant G,Barde YA

更新日期：1990-04-01 00:00:00

abstract：:Two types of ryanodine receptors, channels for Ca2+ release from intracellular stores, are known. We detected the skeletal muscle type only in cerebellum by immunoblot analysis of microsomes and partially purified proteins. The cardiac muscle type was found in all parts of the mouse brain. Immunohistochemical study sh...

journal_title：Neuron

authors： Kuwajima G,Futatsugi A,Niinobe M,Nakanishi S,Mikoshiba K

更新日期：1992-12-01 00:00:00

abstract：:Neurons that release hypocretin/orexin modulate sleep, arousal, and energy homeostasis; the absence of hypocretin results in narcolepsy. Here we present data on the physiological characteristics of these cells, identified with GFP in transgenic mouse brain slices. Hypocretin-1 and -2 depolarized hypocretin neurons by ...

journal_title：Neuron

authors： Li Y,Gao XB,Sakurai T,van den Pol AN

更新日期：2002-12-19 00:00:00

abstract：:Modulation of evoked quantal transmitter release by protein kinase C (PKC) was investigated at an identified cholinergic neuro-neuronal synapse of the Aplysia buccal ganglion. Evoked acetylcholine release was increased by a diacylglycerol analog that activates PKC and was decreased by H-7, a blocker of PKC. FLRFamide ...

journal_title：Neuron

authors： Fossier P,Baux G,Tauc L

更新日期：1990-10-01 00:00:00

abstract：:Several plasma membrane chloride channels are well characterized, but much less is known about the molecular identity and function of intracellular Cl- channels. ClC-3 is thought to mediate swelling-activated plasma membrane currents, but we now show that this broadly expressed chloride channel is present in endosomal...

journal_title：Neuron

authors： Stobrawa SM,Breiderhoff T,Takamori S,Engel D,Schweizer M,Zdebik AA,Bösl MR,Ruether K,Jahn H,Draguhn A,Jahn R,Jentsch TJ

更新日期：2001-01-01 00:00:00

abstract：:In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP)...

journal_title：Neuron

authors： Dragoi G,Harris KD,Buzsáki G

更新日期：2003-08-28 00:00:00

abstract：:Olfaction is a vitally important sense for all animals. There are striking similarities between species in the organization of the olfactory pathway, from the nature of the odorant receptor proteins, to perireceptor processes, to the organization of the olfactory CNS, through odor-guided behavior and memory. These com...

journal_title：Neuron

authors： Ache BW,Young JM

更新日期：2005-11-03 00:00:00

abstract：:Two cDNAs encoding novel GABAA receptor subunits were isolated from a rat brain library. These subunits, gamma 2 and delta, share approximately 35% sequence identity with alpha and beta subunits and form functional GABA-gated chloride channels when expressed alone in vitro. The gamma 2 subunit is the rat homolog of th...

journal_title：Neuron

authors： Shivers BD,Killisch I,Sprengel R,Sontheimer H,Köhler M,Schofield PR,Seeburg PH

更新日期：1989-09-01 00:00:00

abstract：:The perception of visual motion is critical for animal navigation, and flies are a prominent model system for exploring this neural computation. In Drosophila, the T4 cells of the medulla are directionally selective and necessary for ON motion behavioral responses. To examine the emergence of directional selectivity, ...

journal_title：Neuron

authors： Strother JA,Wu ST,Wong AM,Nern A,Rogers EM,Le JQ,Rubin GM,Reiser MB

更新日期：2017-04-05 00:00:00

abstract：:How primates perceive objects along with their detailed features remains a mystery. This ability to make fine visual discriminations depends upon a high-acuity analysis of spatial frequency (SF) along the visual hierarchy from V1 to inferotemporal cortex. By studying the transformation of SF across macaque parafoveal ...

journal_title：Neuron

authors： Lu Y,Yin J,Chen Z,Gong H,Liu Y,Qian L,Li X,Liu R,Andolina IM,Wang W

更新日期：2018-04-18 00:00:00

abstract：:The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates many fundamental brain functions. Studies in humans have suggested that strong LC activation might shift network connectivity to favor salience processing. To causally test this hypothesis, we use a mouse model to study the eff...

journal_title：Neuron

authors： Zerbi V,Floriou-Servou A,Markicevic M,Vermeiren Y,Sturman O,Privitera M,von Ziegler L,Ferrari KD,Weber B,De Deyn PP,Wenderoth N,Bohacek J

更新日期：2019-08-21 00:00:00

abstract：:Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven ...

journal_title：Neuron

authors： Levin N,Dumoulin SO,Winawer J,Dougherty RF,Wandell BA

更新日期：2010-01-14 00:00:00

abstract：:Yang et al. (2016) show that transplantation of GABAergic inhibitory neurons into the amygdala boosts the persistence of fear extinction in mice. Transplantation was found to degrade perineuronal nets on endogenous inhibitory neurons and enhance synaptic plasticity in host amygdala. ...

journal_title：Neuron

authors： Zheng X,Gandhi SP

更新日期：2016-12-21 00:00:00

abstract：:Dendritic spines have been proposed as primary sites of synaptic plasticity in the brain. Consistent with this hypothesis, spines contain high concentrations of actin, suggesting that they might be motile. To investigate this possibility, we made video recordings from hippocampal neurons expressing actin tagged with g...

journal_title：Neuron

authors： Fischer M,Kaech S,Knutti D,Matus A

更新日期：1998-05-01 00:00:00

abstract：:AMPA receptors are thought to be a tetrameric assembly of the subunits GluR1-4. We have examined whether two coexpressed subunits (GluR1/2) combine at random to form channels, or preferentially assemble with a specific stoichiometry and spatial configuration. The subunits carried markers controlling ion permeation and...

journal_title：Neuron

authors： Mansour M,Nagarajan N,Nehring RB,Clements JD,Rosenmund C

更新日期：2001-12-06 00:00:00

abstract：:Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data f...

journal_title：Neuron

authors： Geschwind DH

更新日期：2003-10-30 00:00:00

abstract：:The dynamic interactions between hippocampus and amygdala are critical for emotional memory. Theta synchrony between these structures occurs during fear memory retrieval and may facilitate synaptic plasticity, but the cellular mechanisms are unknown. We report that interneurons of the mouse basal amygdala are activate...

journal_title：Neuron

authors： Bazelot M,Bocchio M,Kasugai Y,Fischer D,Dodson PD,Ferraguti F,Capogna M

更新日期：2015-09-23 00:00:00

abstract：:Pletikos et al. (2014) demonstrate in this issue of Neuron that the human neocortex has an "hourglass" temporal gene expression pattern with robust and dynamic transcriptome differences during the prenatal and adolescent/adult periods. Similar changes are not observed in the nonhuman primate-is this what makes us huma...

journal_title：Neuron

authors： Korade Z,Mirnics K

更新日期：2014-01-22 00:00:00

abstract：:Mesolimbic dopamine (DA) neurons play a central role in motivation and reward processing. Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is known about the circuits in which they are embedded. Using retrograde tracing, electrophysiology, optogenetics, and behavioral assay...

journal_title：Neuron

authors： Yang H,de Jong JW,Tak Y,Peck J,Bateup HS,Lammel S

更新日期：2018-01-17 00:00:00

abstract：:Proper mRNA quality control prevents immune activation; when it goes awry, mice and flies develop abnormal behavioral phenotypes. In this issue of Neuron, Johnson et al. (2019) report that inhibiting nonsense-mediated mRNA decay (NMD) contributes to the pathogenesis of neurodevelopmental disorder (NDD) phenotypes by t...

journal_title：Neuron

authors： Kim E,Huh JR

更新日期：2019-11-20 00:00:00