Abstract:
:The perception of visual motion is critical for animal navigation, and flies are a prominent model system for exploring this neural computation. In Drosophila, the T4 cells of the medulla are directionally selective and necessary for ON motion behavioral responses. To examine the emergence of directional selectivity, we developed genetic driver lines for the neuron types with the most synapses onto T4 cells. Using calcium imaging, we found that these neuron types are not directionally selective and that selectivity arises in the T4 dendrites. By silencing each input neuron type, we identified which neurons are necessary for T4 directional selectivity and ON motion behavioral responses. We then determined the sign of the connections between these neurons and T4 cells using neuronal photoactivation. Our results indicate a computational architecture for motion detection that is a hybrid of classic theoretical models.
journal_name
Neuronjournal_title
Neuronauthors
Strother JA,Wu ST,Wong AM,Nern A,Rogers EM,Le JQ,Rubin GM,Reiser MBdoi
10.1016/j.neuron.2017.03.010subject
Has Abstractpub_date
2017-04-05 00:00:00pages
168-182.e10issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(17)30193-9journal_volume
94pub_type
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