Abstract:
:The signaling mechanisms that control the survival of CNS neurons are poorly understood. Here we show that, in contrast to PNS neurons, the survival of purified postnatal rat retinal ganglion cells (RGCs) in vitro is not promoted by peptide trophic factors unless their intracellular cAMP is increased pharmacologically or they are depolarized by K+ or glutamate agonists. Long-term survival of most RGCs in culture can be promoted by a combination of trophic factors normally produced along the visual pathway, including BDNF, CNTF, IGF1, an oligodendrocyte-derived protein, and forskolin. These results suggest that neurotransmitter stimulation and electrical activity enhance the survival of developing RGCs and raise the question of whether the survival control mechanisms of PNS and CNS neurons are different.
journal_name
Neuronjournal_title
Neuronauthors
Meyer-Franke A,Kaplan MR,Pfrieger FW,Barres BAdoi
10.1016/0896-6273(95)90172-8subject
Has Abstractpub_date
1995-10-01 00:00:00pages
805-19issue
4eissn
0896-6273issn
1097-4199pii
0896-6273(95)90172-8journal_volume
15pub_type
杂志文章相关文献
NEURON文献大全abstract::Embryonic mouse neural tubes produce a variety of terminally differentiated cells in vitro, mostly neurons and glia. We report here that some of these cells differentiate into skeletal muscle cells. The possibility of mesoderm contamination was ruled out as follows. First, Dil+ muscle cells were present in cultures fr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90248-8
更新日期:1994-10-01 00:00:00
abstract::Balance between excitation and inhibition (E-I balance) in neural circuits is believed to be tightly regulated. To the contrary, in this issue of Neuron, Bridi et al. (2020) reveal that inverse oscillations of synaptic inhibition and excitation lead to peaks and valleys in E-I balance across the 24 h day. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2020.01.035
更新日期:2020-02-19 00:00:00
abstract::Advances in optical manipulation and observation of neural activity have set the stage for widespread implementation of closed-loop and activity-guided optical control of neural circuit dynamics. Closing the loop optogenetically (i.e., basing optogenetic stimulation on simultaneously observed dynamics in a principled ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2015.03.034
更新日期:2015-04-08 00:00:00
abstract::Human vision adapts to the contrast of patterns by changing its sensitivity, but the origins of this perceptual adaptation have been disputed. In this issue of Neuron, Solomon et al. show that contrast adaptation in the primate arises mostly in the retina for the magnocellular pathway and mostly in the cortex for the ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/s0896-6273(04)00187-4
更新日期:2004-04-08 00:00:00
abstract::Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging g...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.08.039
更新日期:2018-10-10 00:00:00
abstract::Sensory experience plays an instructive role in the development of the nervous system. Here we showed that visual experience can induce persistent modification of developing retinotectal circuits via spike timing-dependent plasticity (STDP). Pairing light stimuli with spiking of the tectal cell induced persistent enha...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.03.009
更新日期:2006-04-06 00:00:00
abstract::RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.03.014
更新日期:2019-04-17 00:00:00
abstract::Primary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits, mechanisms modulating TrkA or Ret pathways in developing nociceptors are un...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.04.009
更新日期:2014-05-07 00:00:00
abstract::Imaging large-scale circuit dynamics is crucial to understanding brain function, but most techniques have a limited depth of field. Here, we describe volumetric functional ultrasound imaging (vfUSI), a platform for brain-wide vfUSI of hemodynamic activity in awake head-fixed mice. We combined a high-frequency 1,024-ch...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.09.020
更新日期:2020-12-09 00:00:00
abstract::A meta-analysis of non-human primates performing three different tasks (Object-Match, Category-Match, and Category-Saccade associations) revealed signatures of explicit and implicit learning. Performance improved equally following correct and error trials in the Match (explicit) tasks, but it improved more after corre...
journal_title:Neuron
pub_type: 杂志文章,meta分析
doi:10.1016/j.neuron.2017.09.032
更新日期:2017-10-11 00:00:00
abstract::Spike timing-dependent synaptic plasticity (STDP) serves as a key cellular correlate of associative learning, which is facilitated by elevated attentional and emotional states involving activation of adrenergic signaling. At cellular levels, adrenergic signaling increases dendrite excitability, but the underlying mech...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.12.039
更新日期:2017-01-18 00:00:00
abstract::Recent advances in brain imaging techniques, including functional magnetic resonance imaging (fMRI), offer great promise for noninvasive mapping of brain function. However, the indirect nature of the imaging signals to the underlying neural activity limits the interpretation of the resulting maps. The present report r...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00403-3
更新日期:2003-07-17 00:00:00
abstract::Development of neuronal circuits is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1, which mediates attraction through the DCC receptor. We discovered that the Robo3 receptor fundamentally changed its mechanism of acti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.11.004
更新日期:2014-12-17 00:00:00
abstract::Memory enables flexible use of past experience to inform new behaviors. Although leading theories hypothesize that this fundamental flexibility results from the formation of integrated memory networks relating multiple experiences, the neural mechanisms that support memory integration are not well understood. Here, we...
journal_title:Neuron
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neuron.2012.05.010
更新日期:2012-07-12 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.02.008
更新日期:2008-04-24 00:00:00
abstract::The retina adapts to average light intensity but also to the range of light intensities (contrast). A study by Baccus and Meister, in this issue of Neuron, identifies three ways that ganglion cells and interneurons adapt to high contrast: shorten integration time, reduce gain, and depolarize. Only the depolarization d...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/s0896-6273(02)01100-5
更新日期:2002-12-05 00:00:00
abstract::Although deep brain electrical stimulation can alleviate the motor symptoms of Parkinson disease (PD), just a small fraction of patients with PD can take advantage of this procedure due to its invasive nature. A significantly less invasive method--epidural spinal cord stimulation (SCS)--has been suggested as an altern...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.08.061
更新日期:2014-11-19 00:00:00
abstract::Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE also regulates amyloid-β (Aβ) metabolism, aggregation, and deposition. Although earlier work suggests that different affinities of apoE isoforms to Aβ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2014.01.045
更新日期:2014-02-19 00:00:00
abstract::Hippocampal dentate granule cell abnormalities are thought to play a causative role in temporal lobe epilepsy, but their precise contribution has not been dissociated from coexisting pathological changes. In this issue of Neuron, Pun et al. (2012) show, for the first time, that inducing proexcitatory changes in a subs...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2012.09.008
更新日期:2012-09-20 00:00:00
abstract::Visinin is a retinal cone cell-specific protein (molecular weight 24,000, pI 5.1). To investigate its function, visinin cDNA was isolated from a chick retinal lambda gt11 cDNA library, using anti-visinin serum. The beta-galactosidase-visinin fusion protein was used for purifying epitope-selected antibody. The purified...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90059-o
更新日期:1990-03-01 00:00:00
abstract::Memory distortions and illusions have been thoroughly documented in psychological studies, but little is known about the neuroanatomical correlates of true and false memories. Vivid but illusory memories can be induced by asking people whether they recall or recognize words that were not previously presented, but are ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80158-0
更新日期:1996-08-01 00:00:00
abstract::Quaternary ammonium (QA) compounds inhibit K+ conductance by entering and occluding the open pore of voltage-activated K+ channels. We characterized the effects of a series of alkyl-triethylammonium blockers on the Shaker K+ channel and tested them on a series of site-directed mutants of the channel protein in order t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90340-w
更新日期:1993-03-01 00:00:00
abstract::In cerebellar Purkinje cell dendrites, heterosynaptic calcium signaling induced by the proximal climbing fiber (CF) input controls plasticity at distal parallel fiber (PF) synapses. The substrate and regulation of this long-range dendritic calcium signaling are poorly understood. Using high-speed calcium imaging, we e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.08.035
更新日期:2014-10-01 00:00:00
abstract::Changes in intracellular calcium (Ca) concentration following synaptic and suprathreshold activity are mediated by a wide range of sources and contribute to the regulation of myriad neuronal functions. The development of Ca imaging techniques has dramatically increased our understanding of the complex interactions bet...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2008.08.020
更新日期:2008-09-25 00:00:00
abstract::Sequential neural activity patterns are as ubiquitous as the outputs they drive, which include motor gestures and sequential cognitive processes. Neural sequences are long, compared to the activation durations of participating neurons, and sequence coding is sparse. Numerous studies demonstrate that spike-time-depende...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.02.003
更新日期:2010-02-25 00:00:00
abstract::Forty years ago, von Békésy demonstrated that the spatial source of an odorant is determined by comparing input across nostrils, but it is unknown how this comparison is effected in the brain. To address this, we delivered odorants to the left or right of the nose, and contrasted olfactory left versus right localizati...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.06.028
更新日期:2005-08-18 00:00:00
abstract::Neurotropic viruses that conditionally infect or replicate in molecularly defined neuronal subpopulations, and then spread transsynaptically, are powerful tools for mapping neural pathways. Genetically targetable retrograde transsynaptic tracer viruses are available to map the inputs to specific neuronal subpopulation...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.12.002
更新日期:2011-12-22 00:00:00
abstract::Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine with aura that is caused by missense mutations in the CACNA1A gene that encodes the alpha(1) subunit of neuronal Ca(v)2.1 Ca(2+) channels....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00085-6
更新日期:2004-03-04 00:00:00
abstract::In this issue of Neuron, Vyazovskiy et al. reports on progressive changes in cortical unit activity within extended wakefulness and within extended sleep paralleling changes in EEG slow-wave sleep activity. Sleep debt may be integrated at the level of individual cortical neurons, providing support for the synaptic hom...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.09.008
更新日期:2009-09-24 00:00:00
abstract::Social group dynamics are highly complex. In this issue of Neuron, Anpilov et al. use a novel wireless optogenetic device to demonstrate that the repeated stimulation of oxytocin neurons modulates pro-social and agonistic behaviors in a time- and context-dependent manner. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2020.07.027
更新日期:2020-08-19 00:00:00