Abstract:
:The earliest stages of Alzheimer's disease (AD) are characterized by the formation of mature tangles in the entorhinal cortex and disorientation and confusion when navigating familiar places. The medial entorhinal cortex (MEC) contains specialized neurons called grid cells that form part of the spatial navigation system. Here we show in a transgenic mouse model expressing mutant human tau predominantly in the EC that the formation of mature tangles in old mice was associated with excitatory cell loss and deficits in grid cell function, including destabilized grid fields and reduced firing rates, as well as altered network activity. Overt tau pathology in the aged mice was accompanied by spatial memory deficits. Therefore, tau pathology initiated in the entorhinal cortex could lead to deficits in grid cell firing and underlie the deterioration of spatial cognition seen in human AD.
journal_name
Neuronjournal_title
Neuronauthors
Fu H,Rodriguez GA,Herman M,Emrani S,Nahmani E,Barrett G,Figueroa HY,Goldberg E,Hussaini SA,Duff KEdoi
10.1016/j.neuron.2016.12.023subject
Has Abstractpub_date
2017-02-08 00:00:00pages
533-541.e5issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(16)30996-5journal_volume
93pub_type
杂志文章相关文献
NEURON文献大全abstract::The cerebellum is well appreciated to impart speed, smoothness, and precision to skilled movements such as reaching. How these functions are executed by the final output stage of the cerebellum, the cerebellar nuclei, remains unknown. Here, we identify a causal relationship between cerebellar output and mouse reach ki...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.05.007
更新日期:2019-07-17 00:00:00
abstract::Promises are one of the oldest human-specific psychological mechanisms fostering cooperation and trust. Here, we study the neural underpinnings of promise keeping and promise breaking. Subjects first make a promise decision (promise stage), then they anticipate whether the promise affects the interaction partner's dec...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.11.017
更新日期:2009-12-10 00:00:00
abstract::Movements are universally, sometimes frustratingly, variable. When such variability causes error, we typically assume that something went wrong during the movement. The same assumption is made by recent and influential models of motor control. These posit that the principal limit on repeatable performance is neuromusc...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.10.034
更新日期:2006-12-21 00:00:00
abstract::Visual information reaches the brain by way of a fine cable, the optic nerve. The million or so axons in the optic nerve represent an information bottleneck in the visual pathway-where the fewest number of neurons convey the visual scene. It has long been thought that to make the most of the optic nerve's limited capa...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2005.04.018
更新日期:2005-05-05 00:00:00
abstract::In this issue of Neuron, Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3' UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.04.019
更新日期:2019-05-08 00:00:00
abstract::Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76%...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.01.003
更新日期:2015-02-18 00:00:00
abstract::Acetylcholinesterase (AChE) is concentrated at the vertebrate neuromuscular synapse. To determine whether increased transcript levels could underlie this selective accumulation, we employed a quantitative reverse transcription polymerase chain reaction-based assay to determine mRNA copy number in samples as small as s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90151-g
更新日期:1993-09-01 00:00:00
abstract::SCA1, a fatal neurodegenerative disorder, is caused by a CAG expansion encoding a polyglutamine stretch in the protein ATXN1. We used RNA sequencing to profile cerebellar gene expression in Pcp2-ATXN1[82Q] mice with ataxia and progressive pathology and Pcp2-ATXN1[30Q]D776 animals having ataxia in absence of Purkinje c...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.02.011
更新日期:2016-03-16 00:00:00
abstract::The capsaicin receptor, TRPV1, is regulated by phosphatidylinositol-4,5-bisphosphate (PIP(2)), although the precise nature of this effect (i.e., positive or negative) remains controversial. Here, we reconstitute purified TRPV1 into artificial liposomes, where it is gated robustly by capsaicin, protons, spider toxins, ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.12.016
更新日期:2013-02-20 00:00:00
abstract::Respiration is a rhythmic activity as well as one that requires responsiveness to internal and external circumstances; both the rhythm and neuromodulatory responses of breathing are controlled by brainstem neurons in the preBötzinger complex (preBötC) and the retrotrapezoid nucleus (RTN), but the specific ion channels...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.03.024
更新日期:2017-04-19 00:00:00
abstract::We have identified factors that control precise motor timing by studying learning in smooth pursuit eye movements. Monkeys tracked a target that moved horizontally for a fixed time interval before changing direction through the addition of a vertical component of motion. After repeated presentations of the same target...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.12.017
更新日期:2005-01-06 00:00:00
abstract::Cortical plasticity is thought to be important for the establishment, consolidation, and retrieval of permanent memory. Hippocampal long-term potentiation (LTP), a cellular mechanism of learning and memory, requires the activation of glutamate N-methyl-D-aspartate (NMDA) receptors. In particular, it has been suggested...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.08.014
更新日期:2005-09-15 00:00:00
abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synaptic plasticity and memory formation. Although significant progress has been made in understanding the role of postsynaptic CaMKII in synaptic plasticity, very little is known about its presynaptic functio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00143-6
更新日期:2004-04-08 00:00:00
abstract::Interneurons in the ventral spinal cord are essential for coordinated locomotion in vertebrates. During embryogenesis, the V0 and V1 classes of ventral interneurons are defined by expression of the homeodomain transcription factors Evx1/2 and En1, respectively. In this study, we show that Evx1 V0 interneurons are loca...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00213-6
更新日期:2001-02-01 00:00:00
abstract::Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.12.026
更新日期:2006-02-02 00:00:00
abstract::The debate over the nature of mechanisms leading to the establishment of synaptic specificity has engaged neuroscientists for the best part of a century. In this issue of Neuron, Balaskas et al. (2019) provide new evidence in favor of the role of positional strategies in the organization of sensory-motor circuits. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.05.046
更新日期:2019-06-19 00:00:00
abstract::The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAAR) signaling in the pancreas. Their molecular mechanism of action, however, remains e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.001
更新日期:2019-02-20 00:00:00
abstract::Cysteine string protein alpha (CSPalpha)--an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 chaperones--is thought to regulate Ca2+ channels and/or synaptic vesicle exocytosis. We now show that, in young mice, deletion of CSPalpha does not impair survival and causes no significa...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00190-4
更新日期:2004-04-22 00:00:00
abstract::Human vision adapts to the contrast of patterns by changing its sensitivity, but the origins of this perceptual adaptation have been disputed. In this issue of Neuron, Solomon et al. show that contrast adaptation in the primate arises mostly in the retina for the magnocellular pathway and mostly in the cortex for the ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/s0896-6273(04)00187-4
更新日期:2004-04-08 00:00:00
abstract::In a complex nervous system, neuronal functional diversity is reflected in the wide variety of dendritic arbor shapes. Different neuronal classes are defined by class-specific transcription factor combinatorial codes. We show that the combination of the transcription factors Knot and Cut is particular to Drosophila cl...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.10.031
更新日期:2007-12-20 00:00:00
abstract::Neurons adapt their synaptic responses to the activity of the underlying network. In this issue of Neuron, Thiagarajan and colleagues report on specific subcellular mechanisms of homeostasis after prolonged neuronal inactivity. The results have important implications not only for neuronal homeostasis but also for furt...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2005.08.018
更新日期:2005-09-01 00:00:00
abstract::It has recently been found that caspases not only function in apoptosis, but are also crucial for nonapoptotic processes such as NMDA receptor-dependent long-term depression (LTD) of synaptic transmission. It remains unknown, however, how caspases are activated and how neurons escape death in LTD. Here we show that ca...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.04.004
更新日期:2011-05-26 00:00:00
abstract::To learn about the carboxy-terminal extent of amyloid beta-protein (A beta) composition of senile plaques (SPs) in the brain affected with Alzheimer's disease (AD), we employed two end-specific monoclonal antibodies as immunocytochemical probes: one is specific for A beta 40, the carboxyl terminus of A beta 1-40, whil...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90458-8
更新日期:1994-07-01 00:00:00
abstract::To evaluate the role in synaptic plasticity of ryanodine receptor type 3 (RyR3), which is normally enriched in hippocampal area CA1, we generated RyR3-deficient mice. Mutant mice exhibited facilitated CA1 long-term potentiation (LTP) induced by short tetanus (100 Hz, 100 ms) stimulation. Unlike LTP in wild-type mice, ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81123-x
更新日期:1999-11-01 00:00:00
abstract::The neocortex of mammals is composed of cortical fields that have a unique organization associated with the animal's ecological niche and lifestyle. Each cortical field has a specific pattern of connections with other cortical fields and brain structures, and together they comprise a neocortical network that generates...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2007.10.002
更新日期:2007-10-25 00:00:00
abstract::Neuronal activity-dependent processes are believed to mediate the formation of synaptic connections during neocortical development, but the underlying intracellular mechanisms are not known. In the visual system, altering the pattern of visually driven neuronal activity by monocular deprivation induces cortical synapt...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80679-0
更新日期:1999-01-01 00:00:00
abstract::Short-term augmentation of synaptic transmission at sensory neuron synapses of Aplysia contributes to behavioral sensitization and is one of the current models for a cellular mechanism of learning. This neuromodulatory process, mediated at least in part by the facilitatory neurotransmitter serotonin (5-HT) acting thro...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90466-9
更新日期:1994-07-01 00:00:00
abstract::Local axon degeneration is a common pathological feature of many neurodegenerative diseases and peripheral neuropathies. While it is believed to operate with an apoptosis-independent molecular program, the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00429-x
更新日期:2003-07-17 00:00:00
abstract::Regulation of AMPA-type glutamate receptor (AMPAR) number at synapses is a major mechanism for controlling synaptic strength during homeostatic scaling in response to global changes in neural activity. We show that the secreted guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holorece...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.10.029
更新日期:2017-12-06 00:00:00
abstract::In this issue of Neuron, Ajemian et al. present a computational model of the activity of neurons in primary motor cortex (M1) during isometric movements in different postures. By modeling the output of M1 neurons in terms of their influence on muscles, they find each M1 neuron maps its output into a particular pattern...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2008.04.022
更新日期:2008-05-08 00:00:00