NMD Takes the Immune Road to NDD.

abstract：:Cortical motor areas are thought to contribute "higher-order processing," but what that processing might include is unknown. Previous studies of the smooth pursuit-related discharge of supplementary eye field (SEF) neurons have not distinguished activity associated with the preparation for pursuit from discharge relat...

journal_title：Neuron

authors： Shichinohe N,Akao T,Kurkin S,Fukushima J,Kaneko CR,Fukushima K

更新日期：2009-06-11 00:00:00

abstract：:RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...

journal_title：Neuron

authors： Nussbacher JK,Tabet R,Yeo GW,Lagier-Tourenne C

更新日期：2019-04-17 00:00:00

abstract：:We constructed a recombinant baculovirus, A. californica nuclear polyhedrosis virus, containing the Drosophila Shaker H4 K+ channel cDNA under control of the polyhedrin promoter. When infected with this recombinant baculovirus, the cell line Sf9, derived from the army-worm caterpillar S. frugiperda, expresses fully fu...

journal_title：Neuron

authors： Klaiber K,Williams N,Roberts TM,Papazian DM,Jan LY,Miller C

更新日期：1990-08-01 00:00:00

abstract：:Nervous system injury and disease have broad effects on the functional connectivity of the nervous system, but how injury signals are spread across neural circuits remains unclear. We explored how axotomy changes the physiology of severed axons and adjacent uninjured "bystander" neurons in a simple in vivo nerve prepa...

journal_title：Neuron

authors： Hsu JM,Kang Y,Corty MM,Mathieson D,Peters OM,Freeman MR

更新日期：2020-12-02 00:00:00

abstract：:The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3...

journal_title：Neuron

authors： Hippenmeyer S,Shneider NA,Birchmeier C,Burden SJ,Jessell TM,Arber S

更新日期：2002-12-19 00:00:00

abstract：:Each odorant receptor gene defines a unique type of olfactory receptor neuron (ORN) and a corresponding type of second-order neuron. Because each odor can activate multiple ORN types, information must ultimately be integrated across these processing channels to form a unified percept. Here, we show that, in Drosophila...

journal_title：Neuron

authors： Olsen SR,Bhandawat V,Wilson RI

更新日期：2007-04-05 00:00:00

abstract：:Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...

journal_title：Neuron

authors： Kounios J,Smith RW,Yang W,Bachman P,D'Esposito M

更新日期：2001-01-01 00:00:00

abstract：:The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading "activation memories" between inhibitory synapses. Glutamaterg...

journal_title：Neuron

authors： de Luca E,Ravasenga T,Petrini EM,Polenghi A,Nieus T,Guazzi S,Barberis A

更新日期：2017-07-05 00:00:00

abstract：:The time course and functional significance of the structural changes associated with long-term facilitation of Aplysia sensory to motor neuron synaptic connections in culture were examined by time-lapse confocal imaging of individual sensory neuron varicosities labeled with three different fluorescent markers: the wh...

journal_title：Neuron

authors： Kim JH,Udo H,Li HL,Youn TY,Chen M,Kandel ER,Bailey CH

更新日期：2003-09-25 00:00:00

abstract：:Cortical synaptic circuitry develops rapidly in the second postnatal week, simultaneous with experience-dependent turnover of dendritic spines. To relate the emergence of sensory maps to synaptogenesis, we recorded synaptic potentials evoked by whisker deflection in layer 2/3 neurons from postnatal day (P) 12 to 20. A...

journal_title：Neuron

authors： Stern EA,Maravall M,Svoboda K

更新日期：2001-08-02 00:00:00

abstract：:Both the nucleus accumbens (NAc) and basolateral amygdala (BLA) contribute to learned behavioral choice. Neurons in both structures that encode reward-predictive cues may underlie the decision to respond to such cues, but the neural circuits by which the BLA influences reward-seeking behavior have not been established...

journal_title：Neuron

authors： Ambroggi F,Ishikawa A,Fields HL,Nicola SM

更新日期：2008-08-28 00:00:00

abstract：:We perceive motion when presented with spatiotemporal changes in contrast (second-order cue). This requires linear signals to be rectified and then summed in temporal order to compute direction. Although both operations have been attributed to cortex, rectification might occur in retina, prior to the ganglion cell. He...

journal_title：Neuron

authors： Demb JB,Zaghloul K,Sterling P

更新日期：2001-11-20 00:00:00

abstract：:In vivo optogenetics provides unique, powerful capabilities in the dissection of neural circuits implicated in neuropsychiatric disorders. Conventional hardware for such studies, however, physically tethers the experimental animal to an external light source, limiting the range of possible experiments. Emerging wirele...

journal_title：Neuron

authors： Shin G,Gomez AM,Al-Hasani R,Jeong YR,Kim J,Xie Z,Banks A,Lee SM,Han SY,Yoo CJ,Lee JL,Lee SH,Kurniawan J,Tureb J,Guo Z,Yoon J,Park SI,Bang SY,Nam Y,Walicki MC,Samineni VK,Mickle AD,Lee K,Heo SY,McCall JG,

更新日期：2017-02-08 00:00:00

abstract：:Motion detection is a fundamental neural computation performed by many sensory systems. In the fly, local motion computation is thought to occur within the first two layers of the visual system, the lamina and medulla. We constructed specific genetic driver lines for each of the 12 neuron classes in the lamina. We the...

journal_title：Neuron

authors： Tuthill JC,Nern A,Holtz SL,Rubin GM,Reiser MB

更新日期：2013-07-10 00:00:00

abstract：:Firing patterns of neurons in the orbitofrontal cortex (OF) were analyzed in rats trained to perform a task that encouraged incidental associations between distinct odors and the places where their occurrence was detected. Many of the neurons fired differentially when the animals were at a particular location or sampl...

journal_title：Neuron

authors： Lipton PA,Alvarez P,Eichenbaum H

更新日期：1999-02-01 00:00:00

abstract：:Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional...

journal_title：Neuron

authors： Wager TD,Davidson ML,Hughes BL,Lindquist MA,Ochsner KN

更新日期：2008-09-25 00:00:00

abstract：:We have analyzed alternatively spliced beta amyloid protein precursor (beta APP) mRNAs by using the polymerase chain reaction to amplify beta APP cDNAs produced by reverse transcription. With this approach the three previously characterized beta APP mRNAs (beta APP695, beta APP751, and beta APP770) are readily detecte...

journal_title：Neuron

authors： Golde TE,Estus S,Usiak M,Younkin LH,Younkin SG

更新日期：1990-02-01 00:00:00

abstract：:Two papers in the current issue of Neuron (Izuma et al. and Zink et al.) report that activity in specific regions of the brain, especially the striatum, reflects a common signal of reward in both the economic (e.g., money) and social (e.g., praise and status) domains. ...

journal_title：Neuron

authors： Saxe R,Haushofer J

更新日期：2008-04-24 00:00:00

abstract：:The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produc...

journal_title：Neuron

authors： Katz PS

更新日期：1996-02-01 00:00:00

abstract：:Much is known about the functions and properties of neuronal dendrites, but rarely has dendritic activation been monitored while the dendrite performs a computational task. In this issue of Neuron, Bollmann and Engert demonstrate that different regions of a dendrite in the tadpole optic tectum are tuned to stimuli in ...

journal_title：Neuron

authors： Waters J

更新日期：2009-03-26 00:00:00

abstract：:After initial activation by Ca2+, the catalytic activity of type II Ca2+/calmodulin-dependent protein kinase rapidly becomes partially independent of Ca2+. The transition is caused by autophosphorylation of a few subunits in the dodecameric holoenzyme, which is composed of varying proportions of two homologous types o...

journal_title：Neuron

authors： Miller SG,Patton BL,Kennedy MB

更新日期：1988-09-01 00:00:00

abstract：:Cognitive control is subjectively costly, suggesting that engagement is modulated in relationship to incentive state. Dopamine appears to play key roles. In particular, dopamine may mediate cognitive effort by two broad classes of functions: (1) modulating the functional parameters of working memory circuits subservin...

journal_title：Neuron

authors： Westbrook A,Braver TS

更新日期：2016-02-17 00:00:00

abstract：:Accumulation of specific proteins at synaptic structures is essential for synapse assembly and function, but mechanisms regulating local protein enrichment remain poorly understood. At the neuromuscular junction (NMJ), subsynaptic nuclei underlie motor axon terminals within extrafusal muscle fibers and are transcripti...

journal_title：Neuron

authors： Hippenmeyer S,Huber RM,Ladle DR,Murphy K,Arber S

更新日期：2007-09-06 00:00:00

abstract：:In human adults, voices are processed in specialized brain regions in superior temporal cortices. We examined the development of this cortical organization during infancy by using near-infrared spectroscopy. In experiment 1, 7-month-olds but not 4-month-olds showed increased responses in left and right superior tempor...

journal_title：Neuron

authors： Grossmann T,Oberecker R,Koch SP,Friederici AD

更新日期：2010-03-25 00:00:00

abstract：:We have examined the influence of retinal innervation on the development of target neurons in the first optic ganglion, the lamina, of D. melanogaster. Mitotically active lamina precursor cells (LPCs), which normally produce lamina neurons, are absent in mutants that lack retinal innervation, while other proliferative...

journal_title：Neuron

authors： Selleck SB,Steller H

更新日期：1991-01-01 00:00:00

abstract：:The Fragile X mental retardation-1 (Fmr1) gene encodes a multifunctional protein, FMRP, with intrinsic RNA binding activity. We have developed an approach, antibody-positioned RNA amplification (APRA), to identify the RNA cargoes associated with the in vivo configured FMRP messenger ribonucleoprotein (mRNP) complex. U...

journal_title：Neuron

authors： Miyashiro KY,Beckel-Mitchener A,Purk TP,Becker KG,Barret T,Liu L,Carbonetto S,Weiler IJ,Greenough WT,Eberwine J

更新日期：2003-02-06 00:00:00

abstract：:The carboxyl terminus of presenilin 1 and 2 (PS1 and PS2) binds to the neuron-specific cell adhesion molecule telencephalin (TLN) in the brain. PS1 deficiency results in the abnormal accumulation of TLN in a yet unidentified intracellular compartment. The first transmembrane domain and carboxyl terminus of PS1 form a ...

journal_title：Neuron

authors： Annaert WG,Esselens C,Baert V,Boeve C,Snellings G,Cupers P,Craessaerts K,De Strooper B

更新日期：2001-11-20 00:00:00

abstract：:Slob is a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium (K(Ca)) channel. A yeast two-hybrid screen with Slob as bait identifies the zeta isoform of 14-3-3 as a Slob-binding protein. Coimmunoprecipitation experiments from Drosophila heads and trans...

journal_title：Neuron

authors： Zhou Y,Schopperle WM,Murrey H,Jaramillo A,Dagan D,Griffith LC,Levitan IB

更新日期：1999-04-01 00:00:00

abstract：:Fragile X syndrome is a leading heritable cause of mental retardation that results from the loss of FMR1 gene function. A Drosophila model for Fragile X syndrome, based on the loss of dfmr1 activity, exhibits phenotypes that bear similarity to Fragile X-related symptoms. Herein, we demonstrate that treatment with meta...

journal_title：Neuron

authors： McBride SM,Choi CH,Wang Y,Liebelt D,Braunstein E,Ferreiro D,Sehgal A,Siwicki KK,Dockendorff TC,Nguyen HT,McDonald TV,Jongens TA

更新日期：2005-03-03 00:00:00

abstract：:In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate th...

journal_title：Neuron

authors： Rosa JM,Ruehle S,Ding H,Lagnado L

更新日期：2016-04-20 00:00:00