Abstract：
:Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data from human patients provide converging evidence that aberrant tau phosphorylation can cause a neurodegenerative phenotype similar to that seen in human neurodegenerative diseases.
journal_name
Neuronjournal_title
Neuronauthors
Geschwind DHdoi
10.1016/s0896-6273(03)00681-0subject
Has Abstractpub_date
2003-10-30 00:00:00pages
457-60issue
3eissn
0896-6273issn
1097-4199pii
S0896627303006810journal_volume
40pub_type
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