Abstract:
:In this issue, Gill et al. apply holographic optogenetic stimulation in the olfactory bulb to control select neuronal ensembles in 3D. This approach allows them to dissociate the contribution of temporal spike features and spike rate to stimulus detection.
journal_name
Neuronjournal_title
Neuronauthors
Esquivelzeta Rabell J,Haesler Sdoi
10.1016/j.neuron.2020.10.007subject
Has Abstractpub_date
2020-10-28 00:00:00pages
228-230issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(20)30775-3journal_volume
108pub_type
评论,杂志文章相关文献
NEURON文献大全abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) can be regulated by synaptic activity and could therefore be involved in activity-dependent control of neuronal growth. We tested whether increased CaMKII activity in postsynaptic optic tectal neurons can modify the development of retinotectal axons in Xenopus. T...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80072-0
更新日期:1996-03-01 00:00:00
abstract::Compelling evidence links amyloid beta (Aβ) peptide accumulation in the brains of Alzheimer's disease (AD) patients with the emergence of learning and memory deficits, yet a clear understanding of the events that drive this synaptic pathology are lacking. We present evidence that neurons exposed to Aβ are unable to fo...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.09.041
更新日期:2017-10-11 00:00:00
abstract::Our perception of fine visual detail relies on small receptive fields at early stages of visual processing. However, small receptive fields tend to confound the orientation and velocity of moving edges, leading to ambiguous or inaccurate motion measurements (the aperture problem). Thus, it is often assumed that neuron...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00439-2
更新日期:2003-08-14 00:00:00
abstract::Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains, therefore supporting the general idea that tau has prion-like properties, with implications for Alzheimer's disease and other tauopathies. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.06.004
更新日期:2014-06-18 00:00:00
abstract::In a complex nervous system, neuronal functional diversity is reflected in the wide variety of dendritic arbor shapes. Different neuronal classes are defined by class-specific transcription factor combinatorial codes. We show that the combination of the transcription factors Knot and Cut is particular to Drosophila cl...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.10.031
更新日期:2007-12-20 00:00:00
abstract::It is a commonly held view that numbers are represented in an abstract way in both parietal lobes. This view is based on failures to find differences between various notational representations. Here we show that by using relatively smaller voxels together with an adaptation paradigm and analyzing subjects on an indivi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.12.025
更新日期:2007-01-18 00:00:00
abstract::Here we define activities of RIM-binding protein (RBP) that are essential for baseline neurotransmission and presynaptic homeostatic plasticity. At baseline, rbp mutants have a ∼10-fold decrease in the apparent Ca(2+) sensitivity of release that we attribute to (1) impaired presynaptic Ca(2+) influx, (2) looser coupli...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.01.024
更新日期:2015-03-04 00:00:00
abstract::While there are selective regions of occipitotemporal cortex that respond to faces, letters, and bodies, the large-scale neural organization of most object categories remains unknown. Here, we find that object representations can be differentiated along the ventral temporal cortex by their real-world size. In a functi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.04.036
更新日期:2012-06-21 00:00:00
abstract::The N-myc and the L-myc proto-oncogenes are expressed during embryonal development mainly in the developing brain. Studies of their expression in single neuroepithelial cells revealed that neural precursors not yet committed to the glial or the neuronal lineage expressed both genes, but after lineage commitment they e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90079-s
更新日期:1992-12-01 00:00:00
abstract::The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.12.025
更新日期:2006-02-16 00:00:00
abstract::In this issue of Neuron, McGinty et al. (2013) report that the activity of cue-responsive neurons in the rat nucleus accumbens predicts the vigor of the subsequent approach movement. The characterization of this network state between motivation and action lends novel mechanistic insight to a spectrum of cue-elicited b...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2013.05.021
更新日期:2013-06-05 00:00:00
abstract::Brandon et al. (2014) show that the formation of place cell representations in new environments is preserved under septal inactivation, and is thus likely independent of the hippocampal theta rhythm and, by implication, the firing of entorhinal grid cells and the process of path integration. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.05.011
更新日期:2014-05-21 00:00:00
abstract::Sensory information is encoded both in space and in time. Spatial encoding is based on the identity of activated receptors, while temporal encoding is based on the timing of activation. In order to generate accurate internal representations of the external world, the brain must decode both types of encoded information...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(01)00466-4
更新日期:2001-10-25 00:00:00
abstract::We have studied the subcellular distribution of the alpha 1 and alpha 2 subunits of the dihydropyridine (DHP) receptor and ankyrin in rat skeletal muscle with immunofluorescence and immunogold labeling techniques. All three proteins were concentrated in the triad junction formed between the T-tubules and sarcoplasmic ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90170-k
更新日期:1990-09-01 00:00:00
abstract::Neuromodulators are important regulators of synaptic transmission throughout the brain. At the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect transmission not only by changing neurotransmitter release probability, but also by shaping short-term plasticity (STP). Indeed, changes in STP are ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.07.030
更新日期:2018-09-05 00:00:00
abstract::Nearly 25 years ago, the shared interests of psychologists and biologists in understanding the neural basis of social behavior led to the inception of social neuroscience. In the past decade, this field has exploded, in large part due to the infusion of studies that use fMRI. At the same time, tensions have arisen abo...
journal_title:Neuron
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neuron.2013.10.038
更新日期:2013-10-30 00:00:00
abstract::Careful functional dissection of mouse neuromuscular junctions (NMJs) formed in the absence of NCAM reveal that in spite of relatively normal morphology and ultrastructure, the presynaptic terminals have profound alterations in the mechanisms of recycling of synaptic vesicles. These alterations, including the appearan...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(01)00527-x
更新日期:2001-12-06 00:00:00
abstract::Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental question in addiction biology is why exogenous opiate drugs have a high liability for inducing tolerance and addiction while native ligands do not. Studies indicate that highly addictive opiate d...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)80032-5
更新日期:1999-08-01 00:00:00
abstract::We used fMRI to investigate how moment-to-moment neural activity contributes to success or failure on individual trials of a visual working memory (WM) task. We found that different nodes of a distributed cortical network were activated to a greater extent for correct compared to incorrect trials during stimulus encod...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00817-6
更新日期:2002-08-29 00:00:00
abstract::Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is pr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.09.025
更新日期:2018-11-21 00:00:00
abstract::Sleep is an evolutionarily conserved behavioral state whose regulation is poorly understood. A classical model posits that sleep is regulated by homeostatic and circadian mechanisms. Several factors have been implicated in mediating the homeostatic regulation of sleep, but molecules underlying the circadian mechanism ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.02.016
更新日期:2015-03-18 00:00:00
abstract::In the olfactory bulb of vertebrates or the homologous antennal lobe of insects, odor quality is represented by stereotyped patterns of neuronal activity that are reproducible within and between individuals. Using optical imaging to monitor synaptic activity in the Drosophila antennal lobe, we show here that classical...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00217-x
更新日期:2004-05-13 00:00:00
abstract::The relative timing of presynaptic and postsynaptic spikes plays a critical role in activity-induced synaptic modification. Here we examined whether plasticity of orientation selectivity in the visual cortex depends on stimulus timing. Repetitive pairing of visual stimuli at two orientations induced a shift in orienta...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00460-3
更新日期:2001-10-25 00:00:00
abstract::GABAergic interneurons play critical roles in seizures, but it remains unknown whether these vary across interneuron subtypes or evolve during a seizure. This uncertainty stems from the unpredictable timing of seizures in most models, which limits neuronal imaging or manipulations around the seizure onset. Here, we de...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.11.043
更新日期:2017-01-18 00:00:00
abstract::Dopamine (DA) transmission mediates numerous aspects of behavior. Although DA release is strongly linked to firing of DA neurons, recent developments indicate the importance of presynaptic modulation at striatal dopaminergic terminals. The endocannabinoid (eCB) system regulates DA release and is a canonical gatekeeper...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.11.012
更新日期:2017-12-06 00:00:00
abstract::Excessive grooming behaviors, cleansing rituals, and self-mutilation are important features of a range of neuropsychiatric diseases including obsessive compulsive (OC)-spectrum disorders. In this issue of Neuron, Greer and Capecchi (2002) report that Hoxb8 mutant mice exhibit this behavioral phenotype. These Hoxb8 mut...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(01)00575-x
更新日期:2002-01-03 00:00:00
abstract::From the intracellularly recorded responses to small, rapidly flashed spots, we have quantitatively mapped the receptive fields of simple cells in the cat visual cortex. We then applied these maps to a feedforward model of orientation selectivity. Both the preferred orientation and the width of orientation tuning of t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00278-1
更新日期:2001-04-01 00:00:00
abstract::Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical gl...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.02.015
更新日期:2009-03-12 00:00:00
abstract::Critical periods are developmental time windows during which neuronal connections are shaped by experience. In this issue of Neuron, Davis et al. (2015) show that transplantation of embryonic inhibitory interneurons can reactivate critical period plasticity and reverse amblyopia in the visual cortex of adult mice. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.05.003
更新日期:2015-05-20 00:00:00
abstract::Functionally distinct types of neurons develop in stereotypical positions in the vertebrate spinal cord. The mechanisms that generate this diversity have been well studied in the ventral and intermediate regions of the spinal cord, while dorsal cells have received less attention. In this issue of Neuron, two papers fo...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(02)00710-9
更新日期:2002-05-16 00:00:00