Altered representation of the spatial code for odors after olfactory classical conditioning; memory trace formation by synaptic recruitment.

abstract：:In order to deal effectively with danger, it is imperative to know about it. This is what nociceptors do--these primary sensory neurons are specialized to detect intense stimuli and represent, therefore, the first line of defense against any potentially threatening or damaging environmental inputs. By sensing noxious ...

journal_title：Neuron

authors： Woolf CJ,Ma Q

更新日期：2007-08-02 00:00:00

abstract：:The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3 ubiquitin ligases WW-Containing Proteins 1 and 2 (Wwp1 and Wwp2) are indispensable for proper polarization of developing neurons. We show that knockout of Wwp1 and...

journal_title：Neuron

authors： Ambrozkiewicz MC,Schwark M,Kishimoto-Suga M,Borisova E,Hori K,Salazar-Lázaro A,Rusanova A,Altas B,Piepkorn L,Bessa P,Schaub T,Zhang X,Rabe T,Ripamonti S,Rosário M,Akiyama H,Jahn O,Kobayashi T,Hoshino M,Tarabykin V,

更新日期：2018-12-05 00:00:00

abstract：:Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders, but its role in normal neuronal function is largely unknown. Here we show that GSK3beta mediates an interaction between two major forms of synaptic plasticity in the brain, N-methyl-D-aspartate (NMDA) receptor-dependent long-term po...

journal_title：Neuron

authors： Peineau S,Taghibiglou C,Bradley C,Wong TP,Liu L,Lu J,Lo E,Wu D,Saule E,Bouschet T,Matthews P,Isaac JT,Bortolotto ZA,Wang YT,Collingridge GL

更新日期：2007-03-01 00:00:00

abstract：:In this issue of Neuron, Ambrozkiewicz et al. (2018) define a new molecular circuit controlling neuronal polarization and migration through the transcription factor SOX9 to coordinate the production of regulators of both protein synthesis and degradation. ...

journal_title：Neuron

authors： Santiago SE,Barnes AP

更新日期：2018-12-05 00:00:00

abstract：:The trigeminal loop in the brainstem comprises the innermost level of sensorimotor feedback in the rat vibrissa system. Anatomy suggests that this loop relays tactile information from the vibrissae to the motoneurons that control vibrissa movement. We demonstrate, using in vitro and in vivo recordings, that the trigem...

journal_title：Neuron

authors： Nguyen QT,Kleinfeld D

更新日期：2005-02-03 00:00:00

abstract：:Cortical plasticity is thought to be important for the establishment, consolidation, and retrieval of permanent memory. Hippocampal long-term potentiation (LTP), a cellular mechanism of learning and memory, requires the activation of glutamate N-methyl-D-aspartate (NMDA) receptors. In particular, it has been suggested...

journal_title：Neuron

authors： Zhao MG,Toyoda H,Lee YS,Wu LJ,Ko SW,Zhang XH,Jia Y,Shum F,Xu H,Li BM,Kaang BK,Zhuo M

更新日期：2005-09-15 00:00:00

abstract：:From the intracellularly recorded responses to small, rapidly flashed spots, we have quantitatively mapped the receptive fields of simple cells in the cat visual cortex. We then applied these maps to a feedforward model of orientation selectivity. Both the preferred orientation and the width of orientation tuning of t...

journal_title：Neuron

authors： Lampl I,Anderson JS,Gillespie DC,Ferster D

更新日期：2001-04-01 00:00:00

abstract：:Acetylcholinesterase (AChE) density at the neuromuscular junction of frog cutaneous pectoris muscle was determined by electron microscope autoradiography and biochemistry to be approximately 600 sites micron-2 of postsynaptic area, approximately 4-fold lower than all previous reports (mouse), whereas the hydrolytic tu...

journal_title：Neuron

authors： Anglister L,Stiles JR,Salpeter MM

更新日期：1994-04-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heritable, common neurodevelopmental disorder with diverse genetic causes. Several studies have implicated protein synthesis as one among several of its potential convergent mechanisms. We originally identified Janus kinase and microtubule-interacting protein 1 (JAKMIP1) as differen...

journal_title：Neuron

authors： Berg JM,Lee C,Chen L,Galvan L,Cepeda C,Chen JY,Peñagarikano O,Stein JL,Li A,Oguro-Ando A,Miller JA,Vashisht AA,Starks ME,Kite EP,Tam E,Gdalyahu A,Al-Sharif NB,Burkett ZD,White SA,Fears SC,Levine MS,Wohlschlegel

更新日期：2015-12-16 00:00:00

abstract：:Predictive coding posits that neural systems make forward-looking predictions about incoming information. Neural signals contain information not about the currently perceived stimulus, but about the difference between the observed and the predicted stimulus. We propose to extend the predictive coding framework from hi...

journal_title：Neuron

authors： Koster-Hale J,Saxe R

更新日期：2013-09-04 00:00:00

abstract：:Spike timing-dependent synaptic plasticity (STDP) serves as a key cellular correlate of associative learning, which is facilitated by elevated attentional and emotional states involving activation of adrenergic signaling. At cellular levels, adrenergic signaling increases dendrite excitability, but the underlying mech...

journal_title：Neuron

authors： Liu Y,Cui L,Schwarz MK,Dong Y,Schlüter OM

更新日期：2017-01-18 00:00:00

abstract：:Sensory information is actively gathered by animals, but the synaptic mechanisms driving neuronal circuit function during active sensory processing are poorly understood. Here, we investigated the synaptically driven membrane potential dynamics during active whisker sensation using whole-cell recordings from layer 2/3...

journal_title：Neuron

authors： Crochet S,Poulet JF,Kremer Y,Petersen CC

更新日期：2011-03-24 00:00:00

abstract：:Light-induced photoreceptor apoptosis occurs in many forms of inherited retinal degeneration resulting in blindness in both vertebrates and invertebrates. Though mutations in several photoreceptor signaling proteins have been implicated in triggering this process, the molecular events relating light activation of rhod...

journal_title：Neuron

authors： Kiselev A,Socolich M,Vinós J,Hardy RW,Zuker CS,Ranganathan R

更新日期：2000-10-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) can be regulated by synaptic activity and could therefore be involved in activity-dependent control of neuronal growth. We tested whether increased CaMKII activity in postsynaptic optic tectal neurons can modify the development of retinotectal axons in Xenopus. T...

journal_title：Neuron

authors： Zou DJ,Cline HT

更新日期：1996-03-01 00:00:00

abstract：:Unequivocal proof that the activity of a localized cortical neuronal population provides sufficient basis for a specific cognitive function has rarely been obtained. We looked for such proof in monkeys trained to discriminate between two mechanical flutter stimuli applied sequentially to the fingertips. Microelectrode...

journal_title：Neuron

authors： Romo R,Hernández A,Zainos A,Brody CD,Lemus L

更新日期：2000-04-01 00:00:00

abstract：:A new study by Yao et al. in the current issue of Cell proposes that a novel vesicular protein, dubbed Flower, regulates endocytosis by controlling presynaptic Ca(2+) levels. This finding is intriguing not only for its implications for vesicle cycling, but also for the multitude of Ca(2+)-dependent processes at play i...

journal_title：Neuron

authors： Kuo SP,Trussell LO

更新日期：2009-09-10 00:00:00

abstract：:To examine the distribution of synaptic vesicle antigens during development of the cerebral cortex, antibodies against synapsin I and p65 were used on sections of cat cerebral cortex between E40 and adulthood. In the adult, the layers of the cerebral cortex are immunoreactive for each of these antigens, while the whit...

journal_title：Neuron

authors： Chun JJ,Shatz CJ

更新日期：1988-06-01 00:00:00

abstract：:Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein. There are currently no disease-modifying therapies available, but approaches that target proximally in disease pathogenesis hold gre...

journal_title：Neuron

authors： Tabrizi SJ,Ghosh R,Leavitt BR

更新日期：2019-03-06 00:00:00

abstract：:In this issue, Gill et al. apply holographic optogenetic stimulation in the olfactory bulb to control select neuronal ensembles in 3D. This approach allows them to dissociate the contribution of temporal spike features and spike rate to stimulus detection. ...

journal_title：Neuron

authors： Esquivelzeta Rabell J,Haesler S

更新日期：2020-10-28 00:00:00

abstract：:Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal networks. This dysfunction emerges during early development, before a detectable behavioral readout, yet the cellular elements controlling the abnormal maturation are still unknown. Here, we address this open question by...

journal_title：Neuron

authors： Chini M,Pöpplau JA,Lindemann C,Carol-Perdiguer L,Hnida M,Oberländer V,Xu X,Ahlbeck J,Bitzenhofer SH,Mulert C,Hanganu-Opatz IL

更新日期：2020-01-08 00:00:00

abstract：:In this issue of Neuron, Costa et al. (2017) introduce a theoretical framework that predicts the ratio of presynaptic and postsynaptic changes taking place during LTP and LTD and show that these processes co-operate so as to optimize the postsynaptic response statistics. ...

journal_title：Neuron

authors： Poirazi P,Kastellakis G

更新日期：2017-09-27 00:00:00

abstract：:In this issue of Neuron, Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3' UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors. ...

journal_title：Neuron

authors： Panayotis N,Fainzilber M

更新日期：2019-05-08 00:00:00

abstract：:Under ambient air conditions, NO inhibits NMDAR activity by reacting with the NR2A subunit C399 along with two additional cysteine pairs if their disulfide bonds are reduced to free thiol groups [NR1(C744,C798); NR2(C87,C320)]. Here we demonstrate that relative hypoxia enhances S-nitrosylation of NMDARs by a unique me...

journal_title：Neuron

authors： Takahashi H,Shin Y,Cho SJ,Zago WM,Nakamura T,Gu Z,Ma Y,Furukawa H,Liddington R,Zhang D,Tong G,Chen HS,Lipton SA

更新日期：2007-01-04 00:00:00

abstract：:Neurons that release hypocretin/orexin modulate sleep, arousal, and energy homeostasis; the absence of hypocretin results in narcolepsy. Here we present data on the physiological characteristics of these cells, identified with GFP in transgenic mouse brain slices. Hypocretin-1 and -2 depolarized hypocretin neurons by ...

journal_title：Neuron

authors： Li Y,Gao XB,Sakurai T,van den Pol AN

更新日期：2002-12-19 00:00:00

abstract：:Each residue in and flanking the M2 membrane-spanning segment of the alpha subunit, from Glu-241 to Glu-262, was mutated to cysteine, and the mutant subunits were expressed together with wild-type beta, gamma, and delta subunits in Xenopus oocytes. Cysteines substituted for Glu-262, Leu-258, Val-255, Ser-252, Leu-251,...

journal_title：Neuron

authors： Akabas MH,Kaufmann C,Archdeacon P,Karlin A

更新日期：1994-10-01 00:00:00

abstract：:Hundreds of G protein-coupled receptors (GPCRs) and at least six GPCR kinases have been identified, but the only GPCR phosphatase that has been definitively demonstrated is the rhodopsin phosphatase encoded by the rdgC locus of Drosophila. Mutations in rdgC result in defects in termination of the light response and ca...

journal_title：Neuron

authors： Lee SJ,Montell C

更新日期：2001-12-20 00:00:00

abstract：:Neuro-Education is a nascent discipline that seeks to blend the collective fields of neuroscience, psychology, cognitive science, and education to create a better understanding of how we learn and how this information can be used to create more effective teaching methods, curricula, and educational policy. Though stil...

journal_title：Neuron

authors： Carew TJ,Magsamen SH

更新日期：2010-09-09 00:00:00

abstract：:Early postnatal mammals, including human babies, can perform only basic motor tasks. The acquisition of skilled behaviors occurs later, requiring anatomical changes in neural circuitry to support the development of coordinated activation or suppression of functionally related muscle groups. How this circuit reorganiza...

journal_title：Neuron

authors： Gu Z,Serradj N,Ueno M,Liang M,Li J,Baccei ML,Martin JH,Yoshida Y

更新日期：2017-05-03 00:00:00

abstract：:In the brain, enormous numbers of neurons have functional individuality and distinct circuit specificities. Clustered Protocadherins (Pcdhs), diversified cell-surface proteins, are stochastically expressed by alternative promoter choice and affect dendritic arborization in individual neurons. Here we found that the Pc...

journal_title：Neuron

authors： Toyoda S,Kawaguchi M,Kobayashi T,Tarusawa E,Toyama T,Okano M,Oda M,Nakauchi H,Yoshimura Y,Sanbo M,Hirabayashi M,Hirayama T,Hirabayashi T,Yagi T

更新日期：2014-04-02 00:00:00

abstract：:Spine Ca(2+) is critical for the induction of synaptic plasticity, but the factors that control Ca(2+) handling in dendritic spines under physiological conditions are largely unknown. We studied [Ca(2+)] signaling in dendritic spines of CA1 pyramidal neurons and find that spines are specialized structures with low end...

journal_title：Neuron

authors： Sabatini BL,Oertner TG,Svoboda K

更新日期：2002-01-31 00:00:00