Figuring space by time.

abstract：:Serotonin, a neuromodulator at the crayfish neuromuscular junction, regulates neurotransmission without changing intracellular calcium levels. However, the mechanism of this regulation remains unclear. By analysis of synaptic depression using a depletion model and measurement of vesicle recycling using the styryl dye ...

journal_title：Neuron

authors： Wang C,Zucker RS

更新日期：1998-07-01 00:00:00

abstract：:In this issue of Neuron, Fossati et al. (2016) report that through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory and inhibitory synapse development, offering a putative evolutionary genetic mechanism for preserving excitatory/inhibitory balance during speciation. ...

journal_title：Neuron

authors： Subramanian J,Nedivi E

更新日期：2016-07-20 00:00:00

abstract：:Ventral midbrain dopamine (DA) is unambiguously involved in motivation and behavioral arousal, yet the contributions of other DA populations to these processes are poorly understood. Here, we demonstrate that the dorsal raphe nucleus DA neurons are critical modulators of behavioral arousal and sleep-wake patterning. U...

journal_title：Neuron

authors： Cho JR,Treweek JB,Robinson JE,Xiao C,Bremner LR,Greenbaum A,Gradinaru V

更新日期：2017-06-21 00:00:00

abstract：:Brain nicotinic acetylcholine receptors (nAChRs) are made up of protein subunits that differ from those constituting muscle nAChRs. To characterize the physiological properties of one class of avian brain nicotinic receptor, we injected the nuclei of Xenopus oocytes with full-length cDNAs for the ligand binding (alpha...

journal_title：Neuron

authors： Ballivet M,Nef P,Couturier S,Rungger D,Bader CR,Bertrand D,Cooper E

更新日期：1988-11-01 00:00:00

abstract：:Our tactile perception of external objects depends on skin-object interactions. The mechanics of contact dictates the existence of fundamental spatiotemporal input features-contact initiation and cessation, slip, and rolling contact-that originate from the fact that solid objects do not interpenetrate. However, it is ...

journal_title：Neuron

authors： Jörntell H,Bengtsson F,Geborek P,Spanne A,Terekhov AV,Hayward V

更新日期：2014-09-17 00:00:00

abstract：:We developed a technology (capturing activated neuronal ensembles [CANE]) to label, manipulate, and transsynaptically trace neural circuits that are transiently activated in behavioral contexts with high efficiency and temporal precision. CANE consists of a knockin mouse and engineered viruses designed to specifically...

journal_title：Neuron

authors： Sakurai K,Zhao S,Takatoh J,Rodriguez E,Lu J,Leavitt AD,Fu M,Han BX,Wang F

更新日期：2016-11-23 00:00:00

abstract：:Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem ce...

journal_title：Neuron

authors： Hanoun M,Maryanovich M,Arnal-Estapé A,Frenette PS

更新日期：2015-04-22 00:00:00

abstract：:Type IIA rat brain Na+ channel alpha subunits were expressed in CHO cells by nuclear microinjection or by transfection using a vector containing both metallothionein and bacteriophage SP6 promoters. Stable cell lines expressing Na+ channels were isolated, and whole-cell Na+ currents of 0.9-14 nA were recorded. The mea...

journal_title：Neuron

authors： West JW,Scheuer T,Maechler L,Catterall WA

更新日期：1992-01-01 00:00:00

abstract：:Carbon monoxide (CO) induces a long-lasting alteration in cerebellar alpha 3-Na,K-ATPase independent of [Na+] but linked to cGMP synthesis and localized to Purkinje neurons. The action of CO is absent in Purkinje neuron-deficient mice, mimicked by 8-Br-cGMP, and blocked by inhibition of PKG. Glutamate (Glu) and metabo...

journal_title：Neuron

authors： Nathanson JA,Scavone C,Scanlon C,McKee M

更新日期：1995-04-01 00:00:00

abstract：:We constructed a recombinant baculovirus, A. californica nuclear polyhedrosis virus, containing the Drosophila Shaker H4 K+ channel cDNA under control of the polyhedrin promoter. When infected with this recombinant baculovirus, the cell line Sf9, derived from the army-worm caterpillar S. frugiperda, expresses fully fu...

journal_title：Neuron

authors： Klaiber K,Williams N,Roberts TM,Papazian DM,Jan LY,Miller C

更新日期：1990-08-01 00:00:00

abstract：:The decision to engage in one behavior often precludes the selection of others, suggesting cross-inhibition between incompatible behaviors. For example, the likelihood to initiate feeding might be influenced by an animal's commitment to other behaviors. Here, we examine the modulation of feeding behavior in the fruit ...

journal_title：Neuron

authors： Mann K,Gordon MD,Scott K

更新日期：2013-08-21 00:00:00

abstract：:Accumulation of specific proteins at synaptic structures is essential for synapse assembly and function, but mechanisms regulating local protein enrichment remain poorly understood. At the neuromuscular junction (NMJ), subsynaptic nuclei underlie motor axon terminals within extrafusal muscle fibers and are transcripti...

journal_title：Neuron

authors： Hippenmeyer S,Huber RM,Ladle DR,Murphy K,Arber S

更新日期：2007-09-06 00:00:00

abstract：:In the mammalian olfactory bulb, signal processing is mediated by synaptic interactions between dendrites. Glutamate released from mitral cell dendrites excites dendritic spines of granule cells, which in turn release GABA back onto the mitral cell dendrites, forming a reciprocal synaptic pair. This feedback synaptic ...

journal_title：Neuron

authors： Chen WR,Xiong W,Shepherd GM

更新日期：2000-03-01 00:00:00

abstract：:According to economic theories, preference for one item over others reveals its rank value on a common scale. Previous studies identified brain regions encoding such values. Here we verify that these regions can valuate various categories of objects and further test whether they still express preferences when attentio...

journal_title：Neuron

authors： Lebreton M,Jorge S,Michel V,Thirion B,Pessiglione M

更新日期：2009-11-12 00:00:00

abstract：:The motor symptoms of Parkinson's disease (PD) are thought to stem from an imbalance in the activity of striatal direct- and indirect-pathway spiny projection neurons (SPNs). Disease-induced alterations in the activity of networks controlling SPNs could contribute to this imbalance. One of these networks is anchored b...

journal_title：Neuron

authors： Tanimura A,Du Y,Kondapalli J,Wokosin DL,Surmeier DJ

更新日期：2019-02-06 00:00:00

abstract：:Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission, induces synaptic plasticity, and coordinates firing of groups of neurons. As a result, it changes the state of neuronal networks throughout the brain and modifies their response to internal and external inputs: the classical rol...

journal_title：Neuron

authors： Picciotto MR,Higley MJ,Mineur YS

更新日期：2012-10-04 00:00:00

abstract：:Historically, the rat has been the preferred animal model for behavioral studies. Limitations in genome modification have, however, caused a lag in their use compared to the bevy of available transgenic mice. Here, we have developed several transgenic tools, including viral vectors and transgenic rats, for targeted ge...

journal_title：Neuron

authors： Bäck S,Necarsulmer J,Whitaker LR,Coke LM,Koivula P,Heathward EJ,Fortuno LV,Zhang Y,Yeh CG,Baldwin HA,Spencer MD,Mejias-Aponte CA,Pickel J,Hoffman AF,Spivak CE,Lupica CR,Underhill SM,Amara SG,Domanskyi A,Anttila JE,

更新日期：2019-04-03 00:00:00

abstract：:Spine morphology is regulated by intracellular signals, like PKC, that affect cytoskeletal and membrane dynamics. We investigated the role of MARCKS (myristoylated, alanine-rich C-kinase substrate) in dendrites of 3-week-old hippocampal cultures. MARCKS associates with membranes via the combined action of myristoylati...

journal_title：Neuron

authors： Calabrese B,Halpain S

更新日期：2005-10-06 00:00:00

abstract：:Injection of inositol 1,4,5 trisphosphate (InsP3) into Limulus ventral photoreceptors elevates the concentration of intracellular calcium ions and as a consequence depolarizes the photoreceptor. This InsP3-induced elevation can be inhibited by a prior injection of calcium or InsP3 delivered 1 s earlier. Recovery from ...

journal_title：Neuron

authors： Payne R,Flores TM,Fein A

更新日期：1990-04-01 00:00:00

abstract：:Miniature synaptic currents have long been known to represent random transmitter release under resting conditions, but much remains to be learned about their nature and function in central synapses. In this work, we describe a new class of miniature currents ("preminis") that arise by the autocrine activation of axona...

journal_title：Neuron

authors： Trigo FF,Bouhours B,Rostaing P,Papageorgiou G,Corrie JE,Triller A,Ogden D,Marty A

更新日期：2010-04-29 00:00:00

abstract：:The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked m...

journal_title：Neuron

authors： Xiong ZQ,McNamara JO

更新日期：2002-09-12 00:00:00

abstract：:The neocortex of mammals is composed of cortical fields that have a unique organization associated with the animal's ecological niche and lifestyle. Each cortical field has a specific pattern of connections with other cortical fields and brain structures, and together they comprise a neocortical network that generates...

journal_title：Neuron

authors： Krubitzer L

更新日期：2007-10-25 00:00:00

abstract：:N-type calcium channels play a dominant role in controlling synaptic transmission in many peripheral neurons. Transmitter release from mammalian central nerve terminals, however, is relatively resistant to the N channel antagonist omega-conotoxin GVIA. We studied the sensitivity of glutamatergic synaptic transmission ...

journal_title：Neuron

authors： Luebke JI,Dunlap K,Turner TJ

更新日期：1993-11-01 00:00:00

abstract：:We are rapidly approaching a better understanding of the mechanisms that allow our brains to form distinct representations for similar events or episodes. McHugh et al. have brought that goal one step closer by showing that NMDA receptor-dependent synaptic plasticity in the dentate gyrus is necessary for immediate dif...

journal_title：Neuron

authors： Leutgeb JK,Moser EI

更新日期：2007-07-19 00:00:00

abstract：:We have determined the sequences of isoforms of human tau protein, which differ from previously reported forms by insertions of 29 or 58 amino acids in the amino-terminal region. Complementary DNA cloning shows that the insertions occur in combination with both three and four tandem repeats. RNAase protection assays i...

journal_title：Neuron

authors： Goedert M,Spillantini MG,Jakes R,Rutherford D,Crowther RA

更新日期：1989-10-01 00:00:00

abstract：:Sustained rate-coded signals encode many types of sensory modalities. Some sensory synapses possess specialized ribbon structures, which tether vesicles, to enable high-frequency signaling. However, central synapses lack these structures, yet some can maintain signaling over a wide bandwidth. To analyze the underlying...

journal_title：Neuron

authors： Hallermann S,Fejtova A,Schmidt H,Weyhersmüller A,Silver RA,Gundelfinger ED,Eilers J

更新日期：2010-11-18 00:00:00

abstract：:To investigate the role of intracellular Ca2+ in the survival of developing neurons before they become neurotrophic factor dependent, we have studied chick embryo nodose neurons, which have a particularly protracted period of neuorophic factor independence. Pharmacological reduction of intracellular free Ca2+ or deple...

journal_title：Neuron

authors： Larmet Y,Dolphin AC,Davies AM

更新日期：1992-09-01 00:00:00

abstract：:Binocular vision relies upon the existence of contralateral and ispilateral projections from retinal ganglion cells. Contacts between visual axons and optic chiasm cells are critical for the sorting of crossed and uncrossed projections during development. In this issue of Neuron, a study by Williams et al. shows that ...

journal_title：Neuron

authors： Nguyen-Ba-Charvet KT,Chédotal A

更新日期：2006-05-18 00:00:00

abstract：:Many animals guide their movements using optic flow, the displacement of stationary objects across the retina caused by self-motion. How do animals selectively synthesize a global motion pattern from its local motion components? To what extent does this feature selectivity rely on circuit mechanisms versus dendritic p...

journal_title：Neuron

authors： Barnhart EL,Wang IE,Wei H,Desplan C,Clandinin TR

更新日期：2018-10-10 00:00:00

abstract：:In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP)...

journal_title：Neuron

authors： Dragoi G,Harris KD,Buzsáki G

更新日期：2003-08-28 00:00:00