Abstract：
:Circadian clocks consist of transcriptional feedback loops housed in interdependent pacemaker neurons. Yet little is known about the neuronal output components essential for rhythmic behavior. Drosophila mutants of a putative ion channel, narrow abdomen (na), exhibit poor circadian rhythms and suppressed daylight activity. We find that NA is expressed in pacemaker neurons and induced expression within circadian neurons is sufficient to rescue these mutant phenotypes. Selective na rescue in distinct pacemaker neurons influences rhythmicity and timing of behavior. Oscillations of the clock protein PERIOD are intact in na mutants, indicating an output role. Pore residues are required for robust rescue consistent with NA action as an ion channel. In na mutants, expression of potassium currents and the key neuropeptide PDF are elevated, the latter consistent with reduced release. These data implicate NA and the pacemaker neural network in controlling phase and rhythmicity.
journal_name
Neuronjournal_title
Neuronauthors
Lear BC,Lin JM,Keath JR,McGill JJ,Raman IM,Allada Rdoi
10.1016/j.neuron.2005.10.030subject
Has Abstractpub_date
2005-12-22 00:00:00pages
965-76issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(05)00941-4journal_volume
48pub_type
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