Abstract:
:In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate these sustained channels within the inner retina of zebrafish. In OFF bipolar cells, sustained transmission was found to depend on crossover inhibition from the ON pathway through GABAergic amacrine cells. In ON bipolar cells, the amplitude of low-frequency signals was regulated by glycinergic amacrine cells, while GABAergic inhibition regulated the gain of band-pass signals. We also provide the first functional description of a subset of sustained ON bipolar cells in which synaptic activity was suppressed by fluctuations at frequencies above ∼0.2 Hz. These results map out the basic circuitry by which the inner retina generates sustained visual signals and describes a new function of crossover inhibition.
journal_name
Neuronjournal_title
Neuronauthors
Rosa JM,Ruehle S,Ding H,Lagnado Ldoi
10.1016/j.neuron.2016.03.015subject
Has Abstractpub_date
2016-04-20 00:00:00pages
308-19issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(16)30004-6journal_volume
90pub_type
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