Abstract：
:Antibodies were raised to three portions of the predicted sequences of Shaker, a gene that encodes a family of K+ channel components that are produced by the alternative splicing of transcripts. On immunoblots, the protein products appear to be 65,000-85,000 daltons in size. No smaller products were detected. Immunocytochemistry has revealed a nonuniform distribution of Shaker products in the brain of the adult fly. By comparing antisera directed against regions shared by all the splicing variants to antisera that are directed against one particular group of splicing variants, we have determined that there is a differential distribution of that group of variants. Thus, the alternative splicing of Shaker transcripts appears to produce different subtypes of A-channels in different tissues.
journal_name
Neuronjournal_title
Neuronauthors
Schwarz TL,Papazian DM,Carretto RC,Jan YN,Jan LYdoi
10.1016/0896-6273(90)90448-osubject
Has Abstractpub_date
1990-01-01 00:00:00pages
119-27issue
1eissn
0896-6273issn
1097-4199pii
0896-6273(90)90448-Ojournal_volume
4pub_type
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