Purkinje Cells Directly Inhibit Granule Cells in Specialized Regions of the Cerebellar Cortex.

abstract：:alpha-tectorin is an extracellular matrix molecule of the inner ear. Mice homozygous for a targeted deletion in a-tectorin have tectorial membranes that are detached from the cochlear epithelium and lack all noncollagenous matrix, but the architecture of the organ of Corti is otherwise normal. The basilar membranes of...

journal_title：Neuron

authors： Legan PK,Lukashkina VA,Goodyear RJ,Kössi M,Russell IJ,Richardson GP

更新日期：2000-10-01 00:00:00

abstract：:A coculture system consisting of input axons from entorhinal cortex explants and target hippocampal pyramidal neurons was used to demonstrate that glutamate, released spontaneously from afferent axons, can influence both dendritic geometry of target neurons and formation of presumptive synaptic sites. Dendritic outgro...

journal_title：Neuron

authors： Mattson MP,Lee RE,Adams ME,Guthrie PB,Kater SB

更新日期：1988-11-01 00:00:00

abstract：:Kainate receptors signal through both ionotropic and metabotropic pathways. The high-affinity subunits, GluK4 and GluK5, are unique among the five receptor subunits, as they do not form homomeric receptors but modify the properties of heteromeric assemblies. Disruption of the Grik4 gene locus resulted in a significant...

journal_title：Neuron

authors： Fernandes HB,Catches JS,Petralia RS,Copits BA,Xu J,Russell TA,Swanson GT,Contractor A

更新日期：2009-09-24 00:00:00

abstract：:Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional...

journal_title：Neuron

authors： Wager TD,Davidson ML,Hughes BL,Lindquist MA,Ochsner KN

更新日期：2008-09-25 00:00:00

abstract：:The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate ...

journal_title：Neuron

authors： Pearson RA,Dale N,Llaudet E,Mobbs P

更新日期：2005-06-02 00:00:00

abstract：:Neuromuscular junction (NMJ) formation requires agrin, a factor released from motoneurons, and MuSK, a transmembrane tyrosine kinase that is activated by agrin. However, how signal is transduced from agrin to MuSK remains unclear. We report that LRP4, a low-density lipoprotein receptor (LDLR)-related protein, is expre...

journal_title：Neuron

authors： Zhang B,Luo S,Wang Q,Suzuki T,Xiong WC,Mei L

更新日期：2008-10-23 00:00:00

abstract：:Tau protein undergoes a shift in its molecular mass and its electrophoretic complexity during early postnatal development. We have sequenced a tau cDNA from an adult rat brain expression library and have found two inserted sequences. One of these inserts predicts a fourth repeated sequence homologous to the other thre...

journal_title：Neuron

authors： Kosik KS,Orecchio LD,Bakalis S,Neve RL

更新日期：1989-04-01 00:00:00

abstract：:In this issue of Neuron, Ajemian et al. present a computational model of the activity of neurons in primary motor cortex (M1) during isometric movements in different postures. By modeling the output of M1 neurons in terms of their influence on muscles, they find each M1 neuron maps its output into a particular pattern...

journal_title：Neuron

authors： Pesaran B,Movshon JA

更新日期：2008-05-08 00:00:00

abstract：:Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells ...

journal_title：Neuron

authors： Eljaschewitsch E,Witting A,Mawrin C,Lee T,Schmidt PM,Wolf S,Hoertnagl H,Raine CS,Schneider-Stock R,Nitsch R,Ullrich O

更新日期：2006-01-05 00:00:00

abstract：:EPAC proteins are the guanine nucleotide exchange factors that act as the intracellular receptors for cyclic AMP. Two variants of EPAC genes including EPAC1 and EPAC2 are cloned and are widely expressed throughout the brain. But, their functions in the brain remain unknown. Here, we genetically delete EPAC1 (EPAC1(-/-...

journal_title：Neuron

authors： Yang Y,Shu X,Liu D,Shang Y,Wu Y,Pei L,Xu X,Tian Q,Zhang J,Qian K,Wang YX,Petralia RS,Tu W,Zhu LQ,Wang JZ,Lu Y

更新日期：2012-02-23 00:00:00

abstract：:Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique conformations ("strains") in vivo that link structure to patterns of pathology. We now find that tau meets this criterion. Stably expressed tau repeat domain indefin...

journal_title：Neuron

authors： Sanders DW,Kaufman SK,DeVos SL,Sharma AM,Mirbaha H,Li A,Barker SJ,Foley AC,Thorpe JR,Serpell LC,Miller TM,Grinberg LT,Seeley WW,Diamond MI

更新日期：2014-06-18 00:00:00

abstract：:Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...

journal_title：Neuron

authors： Lammel S,Ion DI,Roeper J,Malenka RC

更新日期：2011-06-09 00:00:00

abstract：:Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulated nuclear import of...

journal_title：Neuron

authors： Taniguchi M,Carreira MB,Smith LN,Zirlin BC,Neve RL,Cowan CW

更新日期：2012-01-12 00:00:00

abstract：:Mutations in a synaptic organizing pathway contribute to autism. Autism-associated mutations in MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) are thought to reduce excitatory/inhibitory transmission. However, we show that mutation of Mdga2 elevates excitatory transmission, and that MDGA2 blocks n...

journal_title：Neuron

authors： Connor SA,Ammendrup-Johnsen I,Chan AW,Kishimoto Y,Murayama C,Kurihara N,Tada A,Ge Y,Lu H,Yan R,LeDue JM,Matsumoto H,Kiyonari H,Kirino Y,Matsuzaki F,Suzuki T,Murphy TH,Wang YT,Yamamoto T,Craig AM

更新日期：2016-09-07 00:00:00

abstract：:Presynaptic neurexins (Nrxs) and type IIa receptor-type protein tyrosine phosphatases (RPTPs) organize synapses through a network of postsynaptic ligands. We show that leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) differentially engage the protein domains of Nrx but require its heparan sulfate (HS) modi...

journal_title：Neuron

authors： Roppongi RT,Dhume SH,Padmanabhan N,Silwal P,Zahra N,Karimi B,Bomkamp C,Patil CS,Champagne-Jorgensen K,Twilley RE,Zhang P,Jackson MF,Siddiqui TJ

更新日期：2020-04-08 00:00:00

abstract：:Although numerous theoretical models implicate the prefrontal cortex (PFC) as a source of top-down control signals, empirical support is limited. In this review, we highlight direct evidence for this view of PFC function and discuss several lines of other supportive findings. Most evidence to-date is only suggestive d...

journal_title：Neuron

authors： Miller BT,D'Esposito M

更新日期：2005-11-23 00:00:00

abstract：:We used the cerebellum as a model to study the morphogenetic and cellular processes underlying the formation of elaborate brain structures from a simple neural tube, using an inducible genetic fate mapping approach in mouse. We demonstrate how a 90 degrees rotation between embryonic days 9 and 12 converts the rostral-...

journal_title：Neuron

authors： Sgaier SK,Millet S,Villanueva MP,Berenshteyn F,Song C,Joyner AL

更新日期：2005-01-06 00:00:00

abstract：:Functionally distinct types of neurons develop in stereotypical positions in the vertebrate spinal cord. The mechanisms that generate this diversity have been well studied in the ventral and intermediate regions of the spinal cord, while dorsal cells have received less attention. In this issue of Neuron, two papers fo...

journal_title：Neuron

authors： Matise M

更新日期：2002-05-16 00:00:00

abstract：:Recent advances in connectomics have led to a synthesis of perspectives regarding the brain's functional organization that reconciles classical concepts of localized specialization with an appreciation for properties that emerge from interactions across distributed functional networks. This provides a more comprehensi...

journal_title：Neuron

authors： Matthews PM,Hampshire A

更新日期：2016-08-03 00:00:00

abstract：:To assess the necessary parameters for the growth of axons within the adult rat CNS, we have used intracerebral grafts of primary fibroblasts genetically engineered to express nerve growth factor (NGF). Following the implantation of NGF-producing primary fibroblasts within the striatum, cholinergic axons arising from ...

journal_title：Neuron

authors： Kawaja MD,Gage FH

更新日期：1991-12-01 00:00:00

abstract：:We perceive motion when presented with spatiotemporal changes in contrast (second-order cue). This requires linear signals to be rectified and then summed in temporal order to compute direction. Although both operations have been attributed to cortex, rectification might occur in retina, prior to the ganglion cell. He...

journal_title：Neuron

authors： Demb JB,Zaghloul K,Sterling P

更新日期：2001-11-20 00:00:00

abstract：:Conditioned place preference (CPP) is a widely used model of addiction-related behavior whose underlying mechanisms are not understood. In this study, we used dual site silicon probe recordings in freely moving mice to examine interactions between the hippocampus and nucleus accumbens in cocaine CPP. We found that CPP...

journal_title：Neuron

authors： Sjulson L,Peyrache A,Cumpelik A,Cassataro D,Buzsáki G

更新日期：2018-06-06 00:00:00

abstract：:Visinin is a retinal cone cell-specific protein (molecular weight 24,000, pI 5.1). To investigate its function, visinin cDNA was isolated from a chick retinal lambda gt11 cDNA library, using anti-visinin serum. The beta-galactosidase-visinin fusion protein was used for purifying epitope-selected antibody. The purified...

journal_title：Neuron

authors： Yamagata K,Goto K,Kuo CH,Kondo H,Miki N

更新日期：1990-03-01 00:00:00

abstract：:Phosphatidylinositol 3-kinase (PI3K)-dependent phosphoinositide signaling has been implicated in diverse cellular systems coupled to receptors for many different ligands, but the extent to which it functions in sensory transduction is yet to be determined. We now report that blocking PI3K activity increases odorant-ev...

journal_title：Neuron

authors： Spehr M,Wetzel CH,Hatt H,Ache BW

更新日期：2002-02-28 00:00:00

abstract：:Each odorant receptor gene defines a unique type of olfactory receptor neuron (ORN) and a corresponding type of second-order neuron. Because each odor can activate multiple ORN types, information must ultimately be integrated across these processing channels to form a unified percept. Here, we show that, in Drosophila...

journal_title：Neuron

authors： Olsen SR,Bhandawat V,Wilson RI

更新日期：2007-04-05 00:00:00

abstract：:GABAergic interneurons play critical roles in seizures, but it remains unknown whether these vary across interneuron subtypes or evolve during a seizure. This uncertainty stems from the unpredictable timing of seizures in most models, which limits neuronal imaging or manipulations around the seizure onset. Here, we de...

journal_title：Neuron

authors： Khoshkhoo S,Vogt D,Sohal VS

更新日期：2017-01-18 00:00:00

abstract：:We measured brain activity during mental rotation and object recognition with objects rotated around three different axes. Activity in the superior parietal lobe (SPL) increased proportionally to viewpoint disparity during mental rotation, but not during object recognition. In contrast, the fusiform gyrus was preferen...

journal_title：Neuron

authors： Gauthier I,Hayward WG,Tarr MJ,Anderson AW,Skudlarski P,Gore JC

更新日期：2002-03-28 00:00:00

abstract：:Exocytosis and the cell-averaged cytosolic [Ca2+], [Ca2+]i, were tracked in single gonadotrophs. Cells released 100 granules/s at 1 microM = [Ca2+]i when gonadotropin-releasing hormone (GnRH) activated IP3-mediated Ca2+ release from internal stores, but only 1 granule/s when [Ca2+]i was raised uniformly to 1 microM by...

journal_title：Neuron

authors： Tse FW,Tse A,Hille B,Horstmann H,Almers W

更新日期：1997-01-01 00:00:00

abstract：:The ability of a neuronal surface glycoprotein to mediate the formation of neuronal connections was tested in an explant culture system. A monoclonal antibody against the limbic system-associated membrane protein (LAMP) was used in co-cultures containing cholinergic neurons of the septum and their hippocampal target n...

journal_title：Neuron

authors： Keller F,Rimvall K,Barbe MF,Levitt P

更新日期：1989-11-01 00:00:00

abstract：:The retina adapts to average light intensity but also to the range of light intensities (contrast). A study by Baccus and Meister, in this issue of Neuron, identifies three ways that ganglion cells and interneurons adapt to high contrast: shorten integration time, reduce gain, and depolarize. Only the depolarization d...

journal_title：Neuron

authors： Demb JB

更新日期：2002-12-05 00:00:00